A Sweet Dream with SGLT2 Inhibitors

Abstract

Glucose is an osmotic agent in the peritoneal dialysis fluid (PDF) to absorb water, sodium and other toxins. Glucose absorption from PDF to blood impairs peritoneal dialysis (PD) efficiency and cause glycemic burden. This extra glycemic load leads to poor glycemic control in diabetic dialysis patients with PD program. Studies have shown sodium-glucose co-transporter (SGLT)-2 expression in peritoneal mesothelial cells. Blockade of peritoneal SGLT reduced blood glucose increment and increased peritoneal glucose retention in mice. In rat models, it was shown that high glucose PDF promotes the peritoneal fibrosis by upregulating the expression of glucose transporter (GLUT) and SGLT, and addition of phlorizin to PDF leads to downregulation of GLUT and SGLT expression and reduced peritoneal degeneration. According to these information, we want to share our experience of using empagliflozin in a poor glycemic controlled type 2 diabetic patient, who was on PD program for end-stage renal disease. We hypothesized that if we administer empagliflozin to our patient we can reduce glycemic burden caused by PDF and increase the ultrafiltration volume.

Keywords

• SGLT2 inhibitors
• peritoneal dialysis
• glycemic burden

SGLT2 İnhibitörleri ile Tatlı Bir Rüya

Abstract

Glukoz; su, sodyum ve diğer toksinleri absorbe için periton diyaliz sıvısında bulunan ozmotik bir ajandır. Periton diyaliz sıvısından kana glukoz emilimi periton diyalizi (PD) verimini bozar ve glisemik yüke neden olur. Bu ekstra glisemik yük, PD programındaki diyabetik diyaliz hastalarında kötü glisemik kontrole yol açar. Çalışmalar, peritondaki mezotelyal hücrelerde sodyum-glikoz ko-transporter-2 (SGLT2) ekspresyonunu göstermiştir. Peritoneal SGLT'nin blokajı, farelerde kan glukoz artışını düşürmüş ve peritonal glukoz tutulmasını artırmıştır. Sıçan modellerinde, yüksek glukozlu periton diyaliz sıvısının, glikoz taşıyıcılarını (GLUT) ve SGLT'nin ekspresyonunu artırarak peritoneal fibrozu indüklediği ve periton diyaliz sıvısına florizin eklenmesinin GLUT ve SGLT ekspresyonunu azaltarak ve periton dejenerasyonunun azalmasına neden olduğu gösterilmiştir. Bu bilgilere göre, son dönem böbrek hastalığı için PD programında olan kötü glisemik kontrollü tip 2 diyabetik bir hastada empagliflozin kullanma deneyimimizi paylaşmak istiyoruz. Hastamıza empagliflozin uygulayarak, periton diyaliz sıvısının neden olduğu glisemik yükü azaltabileceğimizi ve ultrafiltrasyon hacmini artırabileceğimizi varsaydık.

Keywords

• SGLT2 inhibitörleri
• periton diyalizi
• glisemik yük

References

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