Effects of Caffeine on Weight Management

Abstract

Obesity, which is rapidly increasing all over the world, has become a serious public health problem. Safe, widely available, and affordable anti-obesity strategies are needed to combat this epidemic problem. In this direction, caffeine, whose anti-obesity effects are frequently emphasized, is the most consumed physioactive substance worldwide. Approximately 80% of individuals all over the world consume caffeine every day, and this has led to increased interest in the effects of caffeine on human health. Many studies have shown that caffeine can affect weight management and health through many mechanisms. In this review, it is aimed to summarize the studies on the effects of caffeine on weight control and its potential mechanisms. In recent studies, it has been concluded that caffeine intake can create a negative energy balance by regulating appetite, increasing thermogenesis and lipolysis, and may be associated with a decrease in the risk of obesity in this way, but there are also conflicting results in the literature. In addition, it should be taken into consideration that there are differences between individuals in the effectiveness of caffeine and that excessive consumption may have negative physiological effects. As a result of the studies examined, it was concluded that a moderate intake of caffeine from natural sources such as coffee, not exceeding 400 milligrams per day, can be used for weight control in a healthy diet program.

Keywords

• Caffeine
• Coffee
• Obesity
• Diet
• Weight Management

Kafeinin Ağırlık Yönetimine Etkileri

Abstract

Tüm dünyada büyük bir hızla artan obezite, ciddi bir halk sağlığı sorunu haline gelmiştir. Salgın boyutundaki bu sorunla mücadele etmek için güvenli, yaygın olarak bulunan ve uygun fiyatlı obezite karşıtı stratejilere ihtiyaç duyulmaktadır. Bu doğrultuda ağırlık yönetimi üzerindeki etkilerine sıklıkla vurgu yapılan kafein dünya genelinde en çok tüketilen fizyoaktif maddedir. Tüm dünyadaki bireylerin yaklaşık %80’i her gün kafein tüketmektedir bu da kafeinin insan sağlığı üzerindeki etkilerine olan ilginin artmasına neden olmuştur. Kafeinin çeşitli mekanizmalar yoluyla ağırlık yönetimi ve sağlık üzerinde etkilerinin olabileceği birçok çalışmada gösterilmiştir. Bu derlemede kafeinin vücut ağırlığı üzerindeki etkileri ve potansiyel etki mekanizmaları konusunda yapılan çalışmaların özetlenmesi amaçlanmıştır. Son zamanlarda yapılan araştırmalarda, kafein alımının iştahı düzenleyip, termogenezi ve lipolizi arttırarak negatif enerji dengesi oluşturabileceği ve bu yolla obezite riskinin azalması ile ilişkili olabileceği sonucuna varılmıştır ancak literatürde birbiriyle çelişen sonuçlar da sıklıkla görülmektedir. Ayrıca kafeinin etkinliğinde bireysel farklılıkların olduğu ve fazla miktarda tüketiminin olumsuz fizyolojik etkilerinin de olabileceği göz önünde bulundurulması gereken diğer konulardır. İncelenen çalışmalar neticesinde kahve gibi doğal kaynaklardan günde 400 miligramı aşmayacak şekilde ılımlı bir kafein alımının sağlıklı bir beslenme ve diyet programında kilo kontrolü amacıyla kullanılabileceği kanısına varılmıştır.

Keywords

• kafein
• kahve
• obezite
• diyet
• ağırlık yönetimi

References

1. 1. Chooi YC, Ding C, Magkos F. The epidemiology of obesity. Metabolism. 2019;92:6-10.
2. 2. Blüher M. Obesity: global epidemiology and pathogenesis. Nature Reviews Endocrinology. 2019;15(5):288-98.
3. 3. Temple JL, Bernard C, Lipshultz SE, Czachor JD, Westphal JA, Mestre MA. The safety of ingested caffeine: a comprehensive review. Frontiers in psychiatry. 2017;8:80.
4. 4. Harpaz E, Tamir S, Weinstein A, Weinstein Y. The effect of caffeine on energy balance. Journal of basic clinical physiology pharmacology. 2017;28(1):1-10.
5. 5. Spiller GA. Caffeine: CRC Press; 2019.
6. 6. Heckman MA, Weil J, De Mejia EG. Caffeine (1, 3, 7‐trimethylxanthine) in foods: a comprehensive review on consumption, functionality, safety, and regulatory matters. Journal of food science. 2010;75(3):R77-R87.
7. 7. Alsabri SG, Mari WO, Younes S, Alsadawi MA, Oroszi TL. Kinetic and dynamic description of caffeine. Journal of Caffeine Adenosine Research. 2018;8(1):3-9.
8. 8. Goldstein ER, Ziegenfuss T, Kalman D, Kreider R, Campbell B, Wilborn C, et al. International society of sports nutrition position stand: caffeine and performance. Journal of the International Society of Sports Nutrition. 2010;7(1):1-15.

9. 9. dePaula J, Farah A. Caffeine Consumption through Coffee: Content in the Beverage, Metabolism, Health Benefits and Risks. 2019;5(2):37.
10. 10. Martínez-López S, Sarriá B, Baeza G, Mateos R, Bravo-Clemente L. Pharmacokinetics of caffeine and its metabolites in plasma and urine after consuming a soluble green/roasted coffee blend by healthy subjects. Food research international. 2014;64:125-33.
11. 11. Tabrizi R, Saneei P, Lankarani KB, Akbari M, Kolahdooz F, Esmaillzadeh A, et al. The effects of caffeine intake on weight loss: a systematic review and dos-response meta-analysis of randomized controlled trials. Critical reviews in food science nutrition reviews. 2019;59(16):2688-96.
12. 12. Lopez-Garcia E, van Dam RM, Rajpathak S, Willett WC, Manson JE, Hu FB. Changes in caffeine intake and long-term weight change in men and women. The American journal of clinical nutrition. 2006;83(3):674-80.
13. 13. Greenberg J, Axen K, Schnoll R, Boozer C. Coffee, tea and diabetes: the role of weight loss and caffeine. International journal of obesity. 2005;29(9):1121-9.
14. 14. Icken D, Feller S, Engeli S, Mayr A, Müller A, Hilbert A, et al. Caffeine intake is related to successful weight loss maintenance. European journal of clinical nutrition. 2016;70(4):532-4.
15. 15. Gavrieli A, Karfopoulou E, Kardatou E, Spyreli E, Fragopoulou E, Mantzoros C, et al. Effect of different amounts of coffee on dietary intake and appetite of normal‐weight and overweight/obese individuals. Obesity. 2013;21(6):1127-32.
16. 16. Greenberg JA, Geliebter A. Coffee, hunger, and peptide YY. Journal of the American College of Nutrition. 2012;31(3):160-6.
17. 17. Schubert MM, Irwin C, Seay RF, Clarke HE, Allegro D, Desbrow B. Caffeine, coffee, and appetite control: a review. International journal of food sciences and nutrition. 2017;68(8):901-12.
18. 18. Gavrieli A, Yannakoulia M, Fragopoulou E, Margaritopoulos D, Chamberland JP, Kaisari P, et al. Caffeinated Coffee Does Not Acutely Affect Energy Intake, Appetite, or Inflammation but Prevents Serum Cortisol Concentrations from Falling in Healthy Men. The Journal of Nutrition. 2011;141(4):703-7.
19. 19. Panek-Shirley LM, DeNysschen C, O’Brien E, Temple JL. Caffeine transiently affects food intake at breakfast. Journal of the Academy of Nutrition Dietetics. 2018;118(10):1832-43.
20. 20. Westerterp-Plantenga MS. Green tea catechins, caffeine and body-weight regulation. Physiology & Behavior. 2010;100(1):42-6.
21. 21. Belza A, Toubro S, Astrup A. The effect of caffeine, green tea and tyrosine on thermogenesis and energy intake. European journal of clinical nutrition. 2009;63(1):57-64.
22. 22. Liu CW, Tsai HC, Huang CC, Tsai CY, Su YB, Lin MW, et al. Effects and mechanisms of caffeine to improve immunological and metabolic abnormalities in diet-induced obese rats. American journal of physiology Endocrinology and metabolism. 2018;314(5):E433-e47.
23. 23. Matsuda Y, Kobayashi M, Yamauchi R, Ojika M, Hiramitsu M, Inoue T, et al. Coffee and caffeine improve insulin sensitivity and glucose tolerance in C57BL/6J mice fed a high-fat diet. Bioscience, biotechnology, biochemistry. 2011;75(12):2309-15.
24. 24. Yamauchi R, Kobayashi M, Matsuda Y, Ojika M, Shigeoka S, Yamamoto Y, et al. Coffee and caffeine ameliorate hyperglycemia, fatty liver, and inflammatory adipocytokine expression in spontaneously diabetic KK-Ay mice. Journal of agricultural food chemistry. 2010;58(9):5597-603.
25. 25. Yeh T-C, Liu C-P, Cheng W-H, Chen B-R, Lu P-J, Cheng P-W, et al. Caffeine intake improves fructose-induced hypertension and insulin resistance by enhancing central insulin signaling. Hypertension. 2014;63(3):535-41.
26. 26. Sınar DS, Acar NE, Yıldırım İ. Kafein ve Obezite. Türkiye Spor Bilimleri Dergisi.3(1):10-20.
27. 27. Riedel A, Pignitter M, Hochkogler CM, Rohm B, Walker J, Bytof G, et al. Caffeine dose-dependently induces thermogenesis but restores ATP in HepG2 cells in culture. Food function. 2012;3(9):955-64.
28. 28. Yang A, Palmer AA, de Wit H. Genetics of caffeine consumption and responses to caffeine. Psychopharmacology. 2010;211(3):245-57.
29. 29. Muhammad HFL, Sulistyoningrum DC, Huriyati E, Lee YY, Manan Wan Muda WA. The interaction between coffee: caffeine consumption, UCP2 gene variation, and adiposity in adults—a cross-sectional study. Journal of nutrition metabolism. 2019;2019.
30. 30. Temple JL, Ziegler AM. Gender differences in subjective and physiological responses to caffeine and the role of steroid hormones. Journal of caffeine research. 2011;1(1):41-8.
31. 31. Temple JL, Ziegler AM, Graczyk A, Bendlin A, Sion T, Vattana K. Cardiovascular responses to caffeine by gender and pubertal stage. Pediatrics. 2014;134(1):e112-e9.
32. 32. Tremblay A, Masson E, Leduc S, Houde A, Després J-P. Caffeine reduces spontaneous energy intake in men but not in women. Nutrition Research. 1988;8(5):553-8.
33. 33. Lee A, Lim W, Kim S, Khil H, Cheon E, An S, et al. Coffee Intake and Obesity: A Meta-Analysis. 2019;11(6):1274.
34. 34. Fulton JL, Dinas PC, Carrillo AE, Edsall JR, Ryan EJ, Ryan EJ. Impact of genetic variability on physiological responses to caffeine in humans: A systematic review. Nutrients. 2018;10(10):1373.
35. 35. Womack CJ, Saunders MJ, Bechtel MK, Bolton DJ, Martin M, Luden ND, et al. The influence of a CYP1A2 polymorphism on the ergogenic effects of caffeine. Journal of the International Society of Sports Nutrition. 2012;9(1):1-6.
36. 36. Rosenfeld LS, Mihalov JJ, Carlson SJ, Mattia A. Regulatory status of caffeine in the United States. Nutrition reviews. 2014;72(suppl_1):23-33.
37. 37. EFSA Panel on Dietetic Products N, Allergies. Scientific Opinion on the safety of caffeine. EFSA Journal. 2015;13(5):4102.
38. 38. Beauchamp G, Amaducci A, Cook MJCPEM. Caffeine toxicity: a brief review and update. 2017;18(3):197-202.
39. 39. Musgrave IF, Farrington RL, Hoban C, Byard RW. Caffeine toxicity in forensic practice: possible effects and under-appreciated sources. Forensic science, medicine, pathology. 2016;12(3):299-303.
40. 40. Hancı M, Bayram S, Karahan S, Kaya E, Bakırcı S. Türk kahvesi ve Türkiye’de satılan bazı içeceklerdeki kafein miktarları. Düzce Tıp Fakültesi Dergisi. 2013;15(3):34-8.