Case Report
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Eruptif Ksantomla Ortaya Çıkan Tip 2 Diabetes Mellitus ve Obeziteli Bir Ağır Hipertrigliseridemi Olgusu

Year 2018, Volume: 2 Issue: 3, 125 - 128, 28.12.2018

Abstract

Hipertrigliseridemi,
obezite ve hipotiroidizm gibi sekonder nedenler haricinde genetik lipid
bozuklukları şeklinde ortaya çıkmaktadır. Farklı klinik prezantasyonları
bulunmasına rağmen erişkin dönemde nadiren eruptif ksantom bulgusuyla
hipertrigliseridemi olguları tanı alır. Burada, şizofreni tanısıyla izlenirken
ciltte döküntüleriyle birlikte diabetes mellitus ve tip 5 hiper
trigliseridemisi tanısı alan bir olguyu sunmaktayız.

References

  • Kushner PA, Cobble ME.Hypertriglyceridemia: the importance of identifying patients at risk. Postgrad Med. 2016;128(8):848-858.
  • Fredrickson DS, Lee RS. A system for phenotyping hyperlipidemia. Circulation 1965;31:321-7.
  • Ginsberg Hn. Diabetic Dyslipidemia: Basic Mechanisms Underlying The Common Hypertriglyceridemia And Low Hdl Cholesterol Levels. Diabetes. 1996; 45(Suppl 3):S27–S30.
  • Zaremba J. Zackiewicz A, Placek W. Eruptive xanthomas. Postep Derm Alergol 2013;30(6):399-402.
  • Bito T, Kawakami C, Shimajiri S, Tokura Y. Generalized eruptive xanthoma with prominent deposition of naked chylomicrons: evidence for chylomicrons as the origin of urate-like crystals. J Cutan Pathol. 2010;37:1161-3.
  • Henning JS, Fazio MG. Yellowish papules on a middle-aged man. Eruptive xanthoma. Am Fam Physician. 2011;83:73-4.
  • Ladizinski B, Lee KC. Eruptive xanthomas in a patient with severe hypertriglyceridemia and type 2 diabetes. CMAJ. 2013;185:1600.
  • Vangara SS, Klingbeil KD, Fertig RM, Radick JL. Severe hypertriglyceridemia presenting as eruptive xanthomatosis. J Family Med Prim Care. 2018;7(1):267-270.
  • Kayaalp O. Hipolipidemik İlaçlar: Kayaalp O, ed. Rasyonel Tedavi Yönünden Tıbbi Farmakoloji. Ankara, Hacettepe TAŞ Kitapçılık Ltd Şti, 2000: 1. cilt, 8.baskı, 567- 587.
  • Hegele RA, Ginsberg HN, Chapman MJ, Nordestgaard BG, Kuivenhoven JA, Averna M, et al. The polygenic nature of hypertriglyceridaemia: Implications for definition, diagnosis, and management. Lancet Diabetes Endocrinol. 2014;2:655–66.
  • Valdivielso P, Ramírez-Bueno A, Ewald N. Current knowledge of hypertriglyceridemic pancreatitis. Eur J Intern Med. 2014;25:689–94

A Case of Severe Hypertrigliseridemia Presentation with Eruptive Xantoma in an Adult with Type-2 Diabetes Mellitus and Obesity

Year 2018, Volume: 2 Issue: 3, 125 - 128, 28.12.2018

Abstract

Hypertriglyceridemia occurs as genetic lipid disorders with the exception of secondary causes such as obesity and hypothyroidism. Although there are different clinical presentations, hypertriglyceridemia cases are rarely seen in adulthood with the presence of eruptive xanthoma. Here, we present a case with schizophrenia diagnosed with skin rashes and diabetes mellitus and severe hypertriglyceridemia. As seen in our case, hyperlipidemias may occur with obesity, diabetes mellitus and antipsychotics in individuals with genetic background. Their presentation may be in the form of eruptive xanthomas, a rare finding. In such cases, effective results can be obtained with a multifaceted approach to metabolic pathways without requiring lipid apheresis.

References

  • Kushner PA, Cobble ME.Hypertriglyceridemia: the importance of identifying patients at risk. Postgrad Med. 2016;128(8):848-858.
  • Fredrickson DS, Lee RS. A system for phenotyping hyperlipidemia. Circulation 1965;31:321-7.
  • Ginsberg Hn. Diabetic Dyslipidemia: Basic Mechanisms Underlying The Common Hypertriglyceridemia And Low Hdl Cholesterol Levels. Diabetes. 1996; 45(Suppl 3):S27–S30.
  • Zaremba J. Zackiewicz A, Placek W. Eruptive xanthomas. Postep Derm Alergol 2013;30(6):399-402.
  • Bito T, Kawakami C, Shimajiri S, Tokura Y. Generalized eruptive xanthoma with prominent deposition of naked chylomicrons: evidence for chylomicrons as the origin of urate-like crystals. J Cutan Pathol. 2010;37:1161-3.
  • Henning JS, Fazio MG. Yellowish papules on a middle-aged man. Eruptive xanthoma. Am Fam Physician. 2011;83:73-4.
  • Ladizinski B, Lee KC. Eruptive xanthomas in a patient with severe hypertriglyceridemia and type 2 diabetes. CMAJ. 2013;185:1600.
  • Vangara SS, Klingbeil KD, Fertig RM, Radick JL. Severe hypertriglyceridemia presenting as eruptive xanthomatosis. J Family Med Prim Care. 2018;7(1):267-270.
  • Kayaalp O. Hipolipidemik İlaçlar: Kayaalp O, ed. Rasyonel Tedavi Yönünden Tıbbi Farmakoloji. Ankara, Hacettepe TAŞ Kitapçılık Ltd Şti, 2000: 1. cilt, 8.baskı, 567- 587.
  • Hegele RA, Ginsberg HN, Chapman MJ, Nordestgaard BG, Kuivenhoven JA, Averna M, et al. The polygenic nature of hypertriglyceridaemia: Implications for definition, diagnosis, and management. Lancet Diabetes Endocrinol. 2014;2:655–66.
  • Valdivielso P, Ramírez-Bueno A, Ewald N. Current knowledge of hypertriglyceridemic pancreatitis. Eur J Intern Med. 2014;25:689–94
There are 11 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Case Report
Authors

Nursel Deveci Çakmak 0000-0002-2170-4969

Ayşe Alpagut This is me

İhsan Ayhan This is me

Rafet Koca This is me

Taner Bayraktaroğlu

Publication Date December 28, 2018
Acceptance Date December 28, 2018
Published in Issue Year 2018 Volume: 2 Issue: 3

Cite

APA Deveci Çakmak, N., Alpagut, A., Ayhan, İ., Koca, R., et al. (2018). Eruptif Ksantomla Ortaya Çıkan Tip 2 Diabetes Mellitus ve Obeziteli Bir Ağır Hipertrigliseridemi Olgusu. Türkiye Diyabet Ve Obezite Dergisi, 2(3), 125-128.
AMA Deveci Çakmak N, Alpagut A, Ayhan İ, Koca R, Bayraktaroğlu T. Eruptif Ksantomla Ortaya Çıkan Tip 2 Diabetes Mellitus ve Obeziteli Bir Ağır Hipertrigliseridemi Olgusu. Turk J Diab Obes. December 2018;2(3):125-128.
Chicago Deveci Çakmak, Nursel, Ayşe Alpagut, İhsan Ayhan, Rafet Koca, and Taner Bayraktaroğlu. “Eruptif Ksantomla Ortaya Çıkan Tip 2 Diabetes Mellitus Ve Obeziteli Bir Ağır Hipertrigliseridemi Olgusu”. Türkiye Diyabet Ve Obezite Dergisi 2, no. 3 (December 2018): 125-28.
EndNote Deveci Çakmak N, Alpagut A, Ayhan İ, Koca R, Bayraktaroğlu T (December 1, 2018) Eruptif Ksantomla Ortaya Çıkan Tip 2 Diabetes Mellitus ve Obeziteli Bir Ağır Hipertrigliseridemi Olgusu. Türkiye Diyabet ve Obezite Dergisi 2 3 125–128.
IEEE N. Deveci Çakmak, A. Alpagut, İ. Ayhan, R. Koca, and T. Bayraktaroğlu, “Eruptif Ksantomla Ortaya Çıkan Tip 2 Diabetes Mellitus ve Obeziteli Bir Ağır Hipertrigliseridemi Olgusu”, Turk J Diab Obes, vol. 2, no. 3, pp. 125–128, 2018.
ISNAD Deveci Çakmak, Nursel et al. “Eruptif Ksantomla Ortaya Çıkan Tip 2 Diabetes Mellitus Ve Obeziteli Bir Ağır Hipertrigliseridemi Olgusu”. Türkiye Diyabet ve Obezite Dergisi 2/3 (December 2018), 125-128.
JAMA Deveci Çakmak N, Alpagut A, Ayhan İ, Koca R, Bayraktaroğlu T. Eruptif Ksantomla Ortaya Çıkan Tip 2 Diabetes Mellitus ve Obeziteli Bir Ağır Hipertrigliseridemi Olgusu. Turk J Diab Obes. 2018;2:125–128.
MLA Deveci Çakmak, Nursel et al. “Eruptif Ksantomla Ortaya Çıkan Tip 2 Diabetes Mellitus Ve Obeziteli Bir Ağır Hipertrigliseridemi Olgusu”. Türkiye Diyabet Ve Obezite Dergisi, vol. 2, no. 3, 2018, pp. 125-8.
Vancouver Deveci Çakmak N, Alpagut A, Ayhan İ, Koca R, Bayraktaroğlu T. Eruptif Ksantomla Ortaya Çıkan Tip 2 Diabetes Mellitus ve Obeziteli Bir Ağır Hipertrigliseridemi Olgusu. Turk J Diab Obes. 2018;2(3):125-8.

Turkish Journal of Diabetes and Obesity (Turk J Diab Obes) is a scientific publication of Zonguldak Bulent Ecevit University Obesity and Diabetes Research and Application Center.

This is a refereed journal, which is published in printed and electronic forms. It aims at achieving free knowledge to the related national and international organizations and individuals.

This journal is published annually three times (in April, August and December).

The publication language of the journal is Turkish and English.