THE EFFECTS OF HIGH DOSE PARACETAMOL ON THYROID FOLLICULAREPITELIAL CELLS IN RAT
Abstract
‘Analgesic’ is
the name given to any drug that is used to make an analgesic effect. Analgesic
drugs act on the central and peripheral nervous system. There are many kinds of
analgesics such as acetaminophen, narcotic drugs, synthetic drugs with the
narcotic effect and nonsteroidal anti inflammatuary drugs (NSAID).
Although the
analgesic action mechanism is unknown, in many studies paracetamol causes dose
dependent significant liver and renal toxcicity, but is stil used without
consideration. In this study we aimed to determine the toxic effects of
paracetamol on thyroid folicular epithelial cells.
For this
purpose, a total of 25 female Wistar albino rats divided into 5 groups which
are the control group (not treated) and paracetamol groups (P7, P14, P21, P28).
750 mg/kg/day paracetamol was given to paracetamol groups via gavaje technique
until the day they were sacrified. After light microscopic histological
examination cytoplasmic vacuolisation, follicular and colloidal degeneration
were detected in paracetamol groups. The average follicular diameter measurement
of the tissue sample sections of the morphometric evaluation of the control
group (57.23±6.45) and the group P7 is examined statistically significantly
(p<0.05). The average height of follicle epithelial of the control group
(0.20 ± 2.19) and the differences were observed statistically significant
between the other groups (p<0.05).
Inconclusion,
based on the results of histological analysis we support that 750 mg/kg/day
dose of paracetamol have toxic effects on thyroid tissue depending on the
duration of use.
Keywords
References
- Banu EREN, Sare SOLMAZ, Zafer EREN, Sevcan MERCAN, Dilek SAĞIR, Burcu YILMAZ
- Ondokuz Mayıs Üniversitesi, Fen Edebiyat Fakültesi, Biyoloji Bölümü Genel Biyoloji Anabilim Dalı Sinop Üniversitesi Sağlık Yüksek Okulu Ordu Üniversitesi Meslek Yüksek Okulu
Details
Primary Language
English
Subjects
-
Journal Section
-
Authors
Sare Solmaz
This is me
Zafer Eren
This is me
Sevcan Mercan
This is me
Dilek Sağır
This is me
Burcu Yılmaz
This is me
Publication Date
February 16, 2017
Submission Date
April 14, 2017
Acceptance Date
-
Published in Issue
Year 2017 Volume: Volume 2 Number: İssue 1 (1)