Abstract
Living organisms require varying amounts of essential metals like iron,
calcium, chromium, copper, manganese, molybdenum, and zinc. Heavy metals such
as arsenic, cadmium, lead and mercury, have no vital or beneficial effect on
organisms. All of these metals are toxic at different concentrations and their
accumulation of human body can cause chronic toxic effects and serious illness.
Human organism accumulates heavy metals as a result of lifestyle and
environmental pollution. Toxic metals
disrupt metabolic functions by accumulating in vital organs and displace of
essential elements. Transporter proteins and metabolism enzymes play
significant role in the detoxification of metals. Genetic polymorphisms of these proteins and
the enzymes change toxicokinetics of trace element and toxic metal body burden.
This presentation includes overview of our results about the effect of gene variants
on metal levels of human blood and tissues. Our researchs cover the following
gene variants: Metal binding proteins, membrane carrier proteins and xenobiotic metabolizing enzymes which are
playing a significant role in metal toxicokinetics. We studied metal levels of
exposed and non exposed human blood, autopsy tissues and placenta. Arsenic,
lead and cadmium levels were quantified using Zeeman Graphite Atomic Absorption
Spectrometry, mercury were analyzed using cold vapor atomic absorption
spectrometry, copper and zinc analysis were carried out a dual atomic
absorption spectrophotometer system. Our results suggest that genetic variation
in proteins and enzymes detoxifying metals, influence toxic metal levels in
human blood and tissues. This situation should be taken into consideration
determining the threshold toxic metal poisoning.
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Abstract
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Details
| Subjects | Internal Diseases |
|---|---|
| Journal Section | Articles |
| Authors | |
| Publication Date | February 16, 2017 |
| Published in Issue | Year 2017 Volume: Volume 2 Issue: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology |
