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THE PROTECTIVE ROLE OF ERDOSTEINE AGAINST CYCLOSPORINE A- INDUCED TESTICULAR TOXICITY

Year 2017, Volume: Volume 2 Issue: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 45 - 45, 16.02.2017

Emel Nacar Zafer Sak , Sedat Motor Ahmet Burak Gurpinar Hasret Ecevit Nebahat Kaplan Sefil Oktay Hasan Ozturk

Abstract

The use of Cyclosporine A (CsA) in cancer is
increasing based on its inhibiting effect on the calcineurin/nuclear factor of
activated T-cells (NFAT) pathway in immune cells. However, its oxidative stress
related toxic side effects reduces its therapeutic potential. Therefore, the
protective effect of Erdosteine (ER) against CsA-induced injury in rat testis
was firstly investigated in the present study. 32 Wistar albino male rats were
randomly divided into four groups; control, CsA (20 mg/kg/day i.p.), CsA + ER
(ER 12 mg/kg/day orally) and only ER. Malondialdehyde (MDA), catalase (CAT),
nitrite/nitrate (expressed as NO), superoxide dismutase (SOD) and glutathion peroxidase
(GSH-Px) levels were evaluated in addition to histological analysis. MDA and NO
levels were significantly increased in CsA group compared to control group.
However, MDA and NO levels significantly decreased in CsA + ER groups compared
to CsA group (p <0,05). Antioxidant enzymes CAT and GSH-Px activities in CsA
group were significantly lower than control group, while CAT activities in CsA
+ ER were significantly lower than other groups (p<0,05). Histological
degeneration in CsA group was significant compared to other groups. Improvement
in ER + CsA group was significant compared to CsA group. In conclusion ER could
have a protective role against testicular injury induced by CsA with its
antioxidant properties

Keywords

THE PROTECTIVE ROLE OF ERDOSTEINE AGAINST CYCLOSPORINE A- INDUCED TESTICULAR TOXICITY

References

  • Turgut Ozal University Vocational School of Health Sciences Pathology Laboratory Tecniques Programme, Ankara
  • Mustafa Kemal University, Medical Faculty, Department of Biochemistry, Antakya, Hatay
  • Akdeniz University, Medical Faculty, Department of Biochemistry, Antalya

Year 2017, Volume: Volume 2 Issue: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 45 - 45, 16.02.2017

Emel Nacar Zafer Sak , Sedat Motor Ahmet Burak Gurpinar Hasret Ecevit Nebahat Kaplan Sefil Oktay Hasan Ozturk

Abstract

References

  • Turgut Ozal University Vocational School of Health Sciences Pathology Laboratory Tecniques Programme, Ankara
  • Mustafa Kemal University, Medical Faculty, Department of Biochemistry, Antakya, Hatay
  • Akdeniz University, Medical Faculty, Department of Biochemistry, Antalya
There are 3 citations in total.

Details

Journal Section Articles
Authors

Emel Nacar This is me

Zafer Sak

Sedat Motor This is me

Ahmet Burak Gurpinar This is me

Hasret Ecevit This is me

Nebahat Kaplan Sefil This is me

Oktay Hasan Ozturk This is me

Publication Date February 16, 2017
Published in Issue Year 2017 Volume: Volume 2 Issue: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology

Cite

APA Nacar, E., Sak, Z., Motor, S., Gurpinar, A. B., et al. (2017). THE PROTECTIVE ROLE OF ERDOSTEINE AGAINST CYCLOSPORINE A- INDUCED TESTICULAR TOXICITY. The Turkish Journal Of Occupational / Environmental Medicine and Safety, Volume 2(İssue 1 (1), 45-45.
AMA Nacar E, Sak Z, Motor S, Gurpinar AB, Ecevit H, Sefil NK, Ozturk OH. THE PROTECTIVE ROLE OF ERDOSTEINE AGAINST CYCLOSPORINE A- INDUCED TESTICULAR TOXICITY. turjoem. February 2017;Volume 2(İssue 1 (1):45-45.
Chicago Nacar, Emel, Zafer Sak, Sedat Motor, Ahmet Burak Gurpinar, Hasret Ecevit, Nebahat Kaplan Sefil, and Oktay Hasan Ozturk. “THE PROTECTIVE ROLE OF ERDOSTEINE AGAINST CYCLOSPORINE A- INDUCED TESTICULAR TOXICITY”. The Turkish Journal Of Occupational / Environmental Medicine and Safety Volume 2, no. İssue 1 (1) (February 2017): 45-45.
EndNote Nacar E, Sak Z, Motor S, Gurpinar AB, Ecevit H, Sefil NK, Ozturk OH (February 1, 2017) THE PROTECTIVE ROLE OF ERDOSTEINE AGAINST CYCLOSPORINE A- INDUCED TESTICULAR TOXICITY. The Turkish Journal Of Occupational / Environmental Medicine and Safety Volume 2 İssue 1 (1) 45–45.
IEEE E. Nacar, Z. Sak, S. Motor, A. B. Gurpinar, H. Ecevit, N. K. Sefil, and O. H. Ozturk, “THE PROTECTIVE ROLE OF ERDOSTEINE AGAINST CYCLOSPORINE A- INDUCED TESTICULAR TOXICITY”, turjoem, vol. Volume 2, no. İssue 1 (1), pp. 45–45, 2017.
ISNAD Nacar, Emel et al. “THE PROTECTIVE ROLE OF ERDOSTEINE AGAINST CYCLOSPORINE A- INDUCED TESTICULAR TOXICITY”. The Turkish Journal Of Occupational / Environmental Medicine and Safety VOLUME 2/İssue 1 (1) (February 2017), 45-45.
JAMA Nacar E, Sak Z, Motor S, Gurpinar AB, Ecevit H, Sefil NK, Ozturk OH. THE PROTECTIVE ROLE OF ERDOSTEINE AGAINST CYCLOSPORINE A- INDUCED TESTICULAR TOXICITY. turjoem. 2017;Volume 2:45–45.
MLA Nacar, Emel et al. “THE PROTECTIVE ROLE OF ERDOSTEINE AGAINST CYCLOSPORINE A- INDUCED TESTICULAR TOXICITY”. The Turkish Journal Of Occupational / Environmental Medicine and Safety, vol. Volume 2, no. İssue 1 (1), 2017, pp. 45-45.
Vancouver Nacar E, Sak Z, Motor S, Gurpinar AB, Ecevit H, Sefil NK, Ozturk OH. THE PROTECTIVE ROLE OF ERDOSTEINE AGAINST CYCLOSPORINE A- INDUCED TESTICULAR TOXICITY. turjoem. 2017;Volume 2(İssue 1 (1):45-.
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