DYNAMIC DISULFIDE/THIOL HOMEOSTASIS IN FIREFIGHTER’S LUNG DISEASE DETECTION

Year 2017, Volume: Volume 2 Issue: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 48 - 48, 16.02.2017

Meşide Gündüzöz Ceylan Bal Sultan Pınar Çetintepe Murat Büyükşekerci Murat Alışık Serpil Erdoğan Servet Birgin İritaş Hınç Yılmaz Engin Tutkun Özcan Erel

Abstract

The potential
for firefighters to involve acute and/or chronic respiratory health
consequences associated with exposures during firefighting activities has long
been recognized. In the state of oxidative
stress thiolsoxidized to disulfide form via reversible thiol-disulphide
exchange reactions. Due to the possibly raised risk for the development of airways
disease among firefighters, it is important that functional respiratory
abnormalities be recognized earlier.

One hundred
firefighters who admitted for periodic medical examination and fifty control
subjects working as officers were recruited as control group. Firemen were classified into three
subgroups: Group 1 consists of those having pulmonary pathology, group 2
comprises those suffering from respiratory disorder, and group 3 contains those
having both pulmonary pathology and respiratory disorder.50 officers
were recruited as control group. Urine arsenic
and serum disulfide/thiol homeostasis were measured.

Urine arsenic,
serum disulphide and % disulfid/ native thiollevels of firefighterswere found
significantly higher than control subjects (p<0.001).  In subgroup analyses; group 1,2 and 3 were
different from control group in terms of arsenic, disulphide and % disulfid/
native thiollevels(p<0.001). Also there is a significantdifference between
group 1 and group 2 and between group 1 and 3 in terms of disulphide and %
disulfid/ native thiol levels (p<0.001).

We revealed for
the first time that disulphide levels, a biomarker of oxidative stress, were
significantly higher in wildfirefighters.

Keywords

DYNAMIC DISULFIDE/THIOL HOMEOSTASIS IN FIREFIGHTER’S LUNG DISEASE DETECTION

References

• Department of Family Medicine, Occupational Diseases Hospital, Ankara, Turkey
• Department of Biochemistry, Yıldırım Beyazıt University, Ankara, Turkey
• Department of Internal Medicine, Hacettepe University, Ankara, Turkey
• Department of Pharmacology, Occupational Diseases Hospital, Ankara, Turkey
• Department of Biochemistry, Atatürk Educational and Research Hospital, Ankara, Turkey
• The Council of Forensic Medicine of Ankara, Turkey
• Department of Toxicology, Occupational Diseases Hospital, Ankara, Turkey