DRUG PRODUCTION AND GOLDENHAR SYNDROME: A CASE REPORT

Year 2017, Volume: Volume 2 Issue: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 49 - 49, 16.02.2017

Servet Irıtas Sultan Pınar Çetintepe Meside Gündüzöz Ceylan Bal Ozlem Kar Kurt

Abstract

 

Goldenhar Syndrome is a congenital defect
characterized by incomplete development of the ear, nose, soft palate, lip, and
mandible. It is associated with anomalous development of the first branchial
arch and second branchial arch. Cardiac, urogenital, skelatal and central
nervous system can be affected. Although most of the patients are sporadic, cases
with autosomal dominant and recessive is seen.

33 years old woman was admitted to our
hospital for having a newborn with Goldenhar Syndrom that can be linked to her
job exposure. She does not smoke and alcohol. She also does not have any
chronic disease. The woman has been working in drug production as a chemistry
technician for 12 years. She has exposed to amoksisilin, potasyum klavunat, siprofloksasin, hidroklorik asid,
atropin, efedrin, parasetamol. She has worked with same chemicals when she was
pregnant. In newborn’s physical examination right part of face, right ear is
incomplete in development. In genetic test there wasn’t any hereditary
pathology.

Use of talidomide,
retinoic acid, tamoxifen and cocaine in pregnancy period is suspected. Additively, diabetes
mellitus, rubella and influenza infection in pregnancy period can be determined
as etiologic factors. New researchs on occupational exposures are needed.

Keywords

DRUG PRODUCTION AND GOLDENHAR SYNDROME: A CASE REPORT

References

• Council of Forensic Medicine, Turkey
• Department of Occupational Medicine, Hacettepe University, Ankara, Turkey
• Department of Family Medicine, Occupational Diseases Hospital, Ankara, Turkey
• Department of Biochemistry, Yıldırım Beyazıt University, Ankara, Turkey