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TARGETING CYCLOOXYGENASE-2 WITH A TARGETED LIPOSOMAL FORMULATION FOR COLORECTAL CANCER.

Year 2017, Volume: Volume 2 Issue: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 88 - 88, 16.02.2017

Abstract

Cyclooxygenase-2
(COX-2) is highly expressed in many different cancers; particularly in
colorectal cancer (CRC). Liposomal drug delivery systems can be used to
increase the therapeutic efficacy of CLX while minimizing its side effects.
Cetuximab (anti-Epidermal Growth Factor Receptor -EGFR- monoclonal antibody) is
a promising targeting ligand since EGFR is highly expressed in a wide range of
solid tumors. Dual targeting of EGFR and COX-2 signaling may have additive or
synergistic effects. Here, we describe an EGFR-targeted immunoliposome for
enhancing the delivery of CLX to cancer cells. 
Cell association studies indicated that the immunoliposome uptake was
higher in EGFR-overexpressing cells compared to the non-targeted liposomes. In
addition, the CLX-loaded-anti-EGFR immunoliposomes were significantly more
toxic compared to the non-targeted ones in cancer cells with EGFR-overexpression
but not in the cells with low EGFR expression, regardless of their COX-2
expression status. Thus, selective targeting of CLX with anti-EGFR
immunoliposomes appears to be a promising strategy for therapy of tumors that
overexpress EGFR.

 





 BAP-07-02-2014-004 and TÜBA-GEBİP

References

  • Sreeparna BANERJEE Department of Biological Sciences, Middle East Technical University, Ankara, Turkey
Year 2017, Volume: Volume 2 Issue: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 88 - 88, 16.02.2017

Abstract

References

  • Sreeparna BANERJEE Department of Biological Sciences, Middle East Technical University, Ankara, Turkey
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Journal Section Articles
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Sreeparna Banerjee This is me

Publication Date February 16, 2017
Published in Issue Year 2017 Volume: Volume 2 Issue: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology

Cite

APA Banerjee, S. (2017). TARGETING CYCLOOXYGENASE-2 WITH A TARGETED LIPOSOMAL FORMULATION FOR COLORECTAL CANCER. The Turkish Journal Of Occupational / Environmental Medicine and Safety, Volume 2(İssue 1 (1), 88-88.
AMA Banerjee S. TARGETING CYCLOOXYGENASE-2 WITH A TARGETED LIPOSOMAL FORMULATION FOR COLORECTAL CANCER. turjoem. February 2017;Volume 2(İssue 1 (1):88-88.
Chicago Banerjee, Sreeparna. “TARGETING CYCLOOXYGENASE-2 WITH A TARGETED LIPOSOMAL FORMULATION FOR COLORECTAL CANCER”. The Turkish Journal Of Occupational / Environmental Medicine and Safety Volume 2, no. İssue 1 (1) (February 2017): 88-88.
EndNote Banerjee S (February 1, 2017) TARGETING CYCLOOXYGENASE-2 WITH A TARGETED LIPOSOMAL FORMULATION FOR COLORECTAL CANCER. The Turkish Journal Of Occupational / Environmental Medicine and Safety Volume 2 İssue 1 (1) 88–88.
IEEE S. Banerjee, “TARGETING CYCLOOXYGENASE-2 WITH A TARGETED LIPOSOMAL FORMULATION FOR COLORECTAL CANCER”., turjoem, vol. Volume 2, no. İssue 1 (1), pp. 88–88, 2017.
ISNAD Banerjee, Sreeparna. “TARGETING CYCLOOXYGENASE-2 WITH A TARGETED LIPOSOMAL FORMULATION FOR COLORECTAL CANCER”. The Turkish Journal Of Occupational / Environmental Medicine and Safety VOLUME 2/İssue 1 (1) (February 2017), 88-88.
JAMA Banerjee S. TARGETING CYCLOOXYGENASE-2 WITH A TARGETED LIPOSOMAL FORMULATION FOR COLORECTAL CANCER. turjoem. 2017;Volume 2:88–88.
MLA Banerjee, Sreeparna. “TARGETING CYCLOOXYGENASE-2 WITH A TARGETED LIPOSOMAL FORMULATION FOR COLORECTAL CANCER”. The Turkish Journal Of Occupational / Environmental Medicine and Safety, vol. Volume 2, no. İssue 1 (1), 2017, pp. 88-88.
Vancouver Banerjee S. TARGETING CYCLOOXYGENASE-2 WITH A TARGETED LIPOSOMAL FORMULATION FOR COLORECTAL CANCER. turjoem. 2017;Volume 2(İssue 1 (1):88-.