TOXICOLOGY INTEGRATED APPROACH TO IDENTIFY CAUSES OF DEATHS AND CHRONIC DISEASES LINKED TO XENOBIOTICS: EVALUATING HAZARDS AND PERSONALIZED RISKS

Year 2017, Volume: Volume 2 Issue: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 90 - 90, 16.02.2017

Aristides M. Tsatsakıs

Abstract

The complex
issue of links between chemical exposures and health problems and diseasesis
associated with multiple factors that are due to the expanding numbers of the
chemical categoriesbeing present simultaneously or sequentially, the variety of
mechanisms, mode of actions, adverse outcome pathways and effects involved but
also on a large number of con-founders and also not less important to be
encounteredsusceptibility due to genetics and epigenetics. Several
epidemiological studies but also in vivo and in vitro experimental works showed
that big majority of man produced consumer products even for dietary or life
style purposes were found to act as endocrine disruptors, neurodevelopmental
toxicants, immunotoxicants and carcinogensin animals and humans. Taking into
consideration most recent aspects for risk assessment of individuals where
exposure assessment is personalized through questionnaires, biomarkers
monitoring, hazard assessment by hazard identification and hazard
characterization for the substances the person is exposed,  mixture interactions and concepts,
susceptibility based on family records and genetic profile, omics, in vitro
based on individual’ cells and diversity between in vivo and vitro data, also
what is called early life exposure and epigenetics and the issue of endocrine
disruption in conjunction with low dose effects and nonmonotonic responses we
can realize the grounds and causation of the incomprehensible and hazy picture
we face in our toxicology evaluations and the timely disagreement in facts
among governmental and other international and authorial regulatory
organizations throughout the world. It is a fact that as we expand the sphere
of our knowledge in general we simultaneously expand the borders of our
knowledge with ignorance. Being highly respectable to Socrates I suggest that
the above sentence takes a step forward and clarifies for the public the deep
meaning of the Socrates statement‘’ I know nothing except the fact of my
ignorance’’. Evaluating effects due to biologically active compounds (xenobiotics,
toxicants) is considered a multifactorial task that needs an integrated and
systematic approach not only for long term actions but often for acute or sub
chronicactions. Since such evaluations are highly work load and time consuming
a sophisticated approach to identify the dominant actions and effects are in
need. Such evaluation approaches will be presented for cases of different types
of exposure related effects in forensic cases and chronic diseases. 

Keywords

TOXICOLOGY INTEGRATED APPROACH TO IDENTIFY CAUSES OF DEATHS AND CHRONIC DISEASES LINKED TO XENOBIOTICS: EVALUATING HAZARDS AND PERSONALIZED RISKS

References

• Aristides M. TSATSAKIS Department of Toxicology & Forensic Science, Medical School, University of Crete, Voutes Campus, Heraklion 71003, Greece