BIOTRANSFORMATION, BIOCUMULATION AND TOXICITY OF SOME PLASTIFIANS (BISPHENOLS; PHTHALATES)

Year 2017, Volume: Volume 2 Issue: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 113 - 113, 16.02.2017

Selçuk Salim Erdoğan Dilek Kaya Akyüzlü Burak Arı

Abstract

Plastifians are
clear, colorless and odourless chemicals produced through the reaction between
alcohol and phtalic anhydrite. They give elasticity and shape to the products
which are procuded through reaction with PVC. They are not only additives like
pigments and filling materials but also chemicals that provide the features of
polymer. The following are among the industrial products including plastifians:
Vinyl, plastic containers, food packages, household goods, cosmetics, child
care products, food imitation products, swimming equipment, gymnastic mats,
sunbeds, seabeds, plastic printings and accessories on textile fabrics,
raincoats, sneakers, plastic slippers, shoes, toners, vinyl flooring, blood
collection tubes, stretch wraps, surgical gloves, respiratory equipment and
masks and other medical equipment.  A, AB,
AF, Bisphenol B, BP, Bisphenol C, Bisphenol E, F, G, M, S, P, PH, TMC and Z
(all from Bisphenols); Di-2sthyl hexyl phthalate (DEHP), Di octyl phthalate
(DOP), Di iso decyl phthalate (DIDP) and Di iso nonyl phthalate (DINP) (all
from Phthalates) are among the best known plastifians. Plastifians are also
known as endocrine disrupting chemicals (EDCs). This very feature of
plastifians can occur through several ways which include binding to steroid
receptors. Some plastifian formulations are proved to have genotoxic features.
Plasitifans, while being absorbed through dermal, oral and inhalation ways, are
exposed to biotransformation in the liver and kidneys and can have a mutagenic
and carcinogenic effect bioaccumulatively in the hormonal system within the endocrine
system especially in the fat cells.

BPA, mostly
taken into the body orally, are transformed into bisphenol A-glucuronide with a
water-soluble metabolite in the intestines and liver. Being exposed to
plastifians especially like bisphenol A even at a low dose can lead to such
problems as breast and prostate cancer, decline in the sperm counts, abnormal
penile/urethral growth in men, sexual precocity in women, increasing obesity,
type 2 neurobehavioral disorders, diabetes, immune system disorders, endocrine,
development and fertility disorders, birth defects, hormonal changes,
infertility and weakness in the immune system.

Keywords

BIOTRANSFORMATION

References

• Selçuk Salim ERDOĞAN, Dilek KAYA AKYÜZLÜ, Burak ARI
• Ankara University Institute of Forensic Sciences Forensic Medicine of Ankara Group Presidency, The Ministry of Health of the Republic of Turkey