EFFECST OF SOME ANTIINFLAMATORY-ANTIRHEUMATIC AND ANALGESICS DRUGS ON PERCENTAGE OF SURVIVAL IN DROSOPHILA MELANOGASTER

Year 2017, Volume: Volume 2 Issue: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 138 - 138, 16.02.2017

Pınar Arslan

Abstract

According to
Turkey Drug Market Survey Report-1, the antiinflamatory-antirheumatic products
market rate were 40.77% and the analgesics 10.58% in total.  It is an indicator that these drugs are
prescribe frequently andunconsciously. Therefore, aim of this study was to
investigate potential effect of diclofenac sodium, active ingredient of
antiinflamatory and antirheumaticdrug A and paracetamol, propyphenazone and
caffeine, the active ingredient of the B analgesic formulation on survival
percentage of Drosophila melanogaster (mwhxflr3).

Trans-heterozygous
larvae, 72h the mwh-flr3 Drosophila cross were chronically fed with distilled
water for the control group; 0.1 and 1 mg/mL concentrations of drug A; 0.45 and
4.5 mg/mL concentrations of drug B for experimental groups. During the
experiment, 3 g Drosophila medium was wetted with 10 mL test solution, and 100
larvae were embedded in the medium for each group.  After the experiment, the percentage of
survival between experimental and control groups were compared using Chi-squared
test.

The survival
percentages of Drosophila melanogaster (mwhxflr3) were calculated as77 in 0.1
and 75 in 1 mg/mL in drug A; 74 in 0.45 mg/mL and 71 4.5 mg/mL in drug B; 97 in
the control group. Only Drug B is toxic at higher dose (0.45 mg/mL).

Keywords

EFFECST OF SOME ANTIINFLAMATORY-ANTIRHEUMATIC AND ANALGESICS DRUGS ON PERCENTAGE OF SURVIVAL IN DROSOPHILA MELANOGASTER

References

• Pınar ARSLAN, Rabia SARIKAYA
• Department of Biology Education, Gazi Faculty of Education, Gazi University, Ankara Department of Primary School Education, Gazi Faculty of Education, Gazi University, Ankara