. TBARS, SH AND NITRIC OXIDE LEVELS IN MALE WORKERS WITH OCCUPATIONAL LEAD EXPOSURE

Year 2017, Volume: Volume 2 Issue: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 208 - 208, 16.02.2017

Gülsen Yılmaz Hatice Sürer Elmas Öğüş Engin Tutkun Hınç Yılmaz Fatma Meriç Yılmaz

Abstract

To determine
TBARS (thiobarbituric acid reactive sobstances), SH (thiols) and NOx (Nitric
Oxide metabolites) levels as indicators of oxidative stress, to discuss the
correlation of oxidative stres with blood lead (Pb) concentrations and discuss
the interactions between NOx and oxidative stress in workers with occupational
lead exposure.

104 battery
workers with lead exposure and 50 healthy controls without a lead exposure were
included in the study.  Pb exposed
workers were divided into two subgroups according to their Pb concentration;
Group A: Pb ≤ 30 µg/dL (n= 52) and Group B: Pb > 30 µg/dL (n= 52).

TBARS levels
were significantly higher, SH levels were significantly lower in both of the
exposed groups when compared with controls. TBARS levels were found to be
significantly higher and SH levels were found to be significantly lower in
Group B when compared with Group A indicating that the oxidative stress
increases with the increasing blood lead levels. There was not a significant
difference in NOx levels.

The results of
the study showed that the prooxidant-antioxidant balance in Pb exposure is
disturbed by inducing over-production of TBARS and depleting the antioxidant
capacity in a Pb concentration dependent manner. Oxidative stress has been
proposed to be a principle mechanism involved in Pb toxicity.

 

Keywords

. TBARS

References

• Gülsen YILMAZ, Hatice SÜRER, Elmas ÖĞÜŞ, Engin TUTKUN, Hınç YILMAZ, Fatma Meriç YILMAZ
• Department of Medical Biochemistry, Yıldırım Beyazıt University Medicine Faculty, Ankara, Turkey Department of Medical Biochemistry, Ankara Training and Research Hospital, Ankara, Turkey Ankara Occupational Diseases Hospital, Ankara, Turkey