EFFECT OF THE ANTI-TNF DRUGS ON CYTOCHROME P450 2C19 ACTIVITY

Year 2017, Volume: Volume 2 Issue: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 214 - 214, 16.02.2017

Mustafa Tugrul Goktas Erdem K. Özer Halil Kara İlknur Albayrak Gezer Umit Yasar

Abstract

Ankylosing spondylitis (AS) is an
autoimmune disease. Proinflammatory cytokines, such as TNF-α, IL-6, IL-17 and
IL-23 have been shown to increase in patients with ankylosing spondylitis.
Tumor necrosis factor-alpha (TNFα) blockers, such as etanercept, infliximab,
golimumab and adalimumab are an alternative treatment in the AS patients. We
previously showed that CYP2C19 activity was lower in AS patients compared to
that of the healthy volunteers. The purpose of this study was to evaluate the
effect of TNF antagonists (etanercept, infliximab, golimumab and adalimumab) on
the CYP2C19 enzyme activity.

Eleven AS patients using TNFα
blockers and 21 AS patients not treated with TNF-α blockers were included in
the study. CYP2C19 enzyme activity was determined by lansoprazole metabolic
ratio (lansoprazole/5-hydroxy lansoprazole) using high pressure liquid chromatography.
Difference in the metabolic ratios of lansoprazole was compared with
Mann–Whitney U test.

The mean values of lansoprazole
metabolic ratio were 27.2 and 20.0 in Anti-TNF user and non-user AS patient
groups (p=0.28, median and 95% CI: 25.0 [15.0-39.5] and 13.3 [13.4-26.6],
respectively).

CYP2C19 enzyme activity was
similar in Anti-TNF user and non-user. Anti-TNF drugs do not seem to interact
with CYP2C19 substrates at the level of drug metabolism.

 

 

Keywords

EFFECT OF THE ANTI-TNF DRUGS ON CYTOCHROME P450 2C19 ACTIVITY

References

• Mustafa Tugrul GOKTAS, Erdem K. ÖZER, Halil KARA, Ilknur ALBAYRAK GEZER, Umit YASAR
• Yildirim Beyazit University, Faculty of Medicine, Department of Pharmacology, Ankara, Turkey Selçuk University, Faculty of Medicine, Department of Pharmacology, Konya, Turkey Selçuk University, Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Konya, Turkey Hacettepe University, Faculty of Medicine, Department of Pharmacology, Ankara, Turkey