DIMETHOATE-INDUCED TOXICITY IN RAT BRAIN AND THE AMELIORATIVE EFFECT OF LAUROCERASUS OFFICINALIS ROEM. (CHERRY LAUREL) FRUIT EXTRACT

Year 2017, Volume: Volume 2 Issue: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 251 - 251, 16.02.2017

Ayşe Eken , Elçin Özger Burcu Ünlü-endırlık Ayşe Baldemır Arzu Hanım Yay Fazile Cantürk Yusuf Caner

Abstract

Dimethoate is
one of the most important organophosphate insecticide and causes oxidative
stress. Cherry laurel (Laurocerasus officinalis Roem.) fruit contains various
bioactive compounds that possess antioxidant activity. The aim of the study was
to determine the effect of dimethoate on oxidative stress, DNA fragmentation in
rat brain and the ameliorative effects of Laurocerasus officinalis Roem.
(cherry laurel) fruit extract. Therefore, superoxide dismutase (SOD), catalase
(CAT), glutathione peroxidase (GPx), malondialdehyde (MDA), comet assay and
TUNEL for DNA damage index, and histologic examination were evaluated in rat
brain. Treatment with dimethoate caused an increase in MDA, DNA damage and a
decrease in enzyme activities of SOD, CAT, GPx as compared to control group.
Administration of L. officinalis to dimethoate-treated groups provided a
reduction in oxidative stress status and DNA damage compared to the only
dimethoate-treated group. Our results showed that treatment with L. officinalis
fruit extract repaired the toxicity of brain induced by dimethoate. 

Keywords

DIMETHOATE-INDUCED TOXICITY IN RAT BRAIN AND THE AMELIORATIVE EFFECT OF LAUROCERASUS OFFICINALIS ROEM. (CHERRY LAUREL) FRUIT EXTRACT

References

• Ayşe EKEN, Elçin ÖZGER, Burcu ÜNLÜ-ENDIRLIK, Ayşe BALDEMIR, Arzu Hanım YAY, Fazile CANTÜRK, Yusuf CANER
• Erciyes University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Kayseri, Turkey Erciyes University, Faculty of Pharmacy, Department of Pharmaceutical Botany, Kayseri, Turkey Erciyes University, Faculty of Medicine, Department of Basic Sciences, Kayseri, Turkey