Abstract
According to ISO
uncertainity is a parameter associated with the result of measurement that
characterizes the dispersion of the values that could reasonably be attributed
to the measurand. The aim of this study is to calculate measurement uncertainty
of valproic acid by using internal quality control data and inter laboratory
results to compare these calculated measurement uncertainties with total
allowable error % (TEa %) value of CLIA'88.
Between October
2015 and March 2016, the internal quality control datas were screened. The
estimation of valproic acid measurement uncertainity was calculated according
to ISO21748 guide. Inter laboratory comparison was executed to estimate bias.
Valproic acid levels were determined using the immunoturbidimetric method on
the Roche Cobas Integra 800 analyzer.
Coefficient
variations (CV) calculated from internal quality control analyses were 2.12,
2.46 and 3.01 at low, normal and high level of internal quality control sera
values respectively. Total allowable error value of valproic acid was 9.94% and
was not higher than desirable TEa% values of CLIA'88.
Valproic
acid is a widely-used first-generation antiepileptic drug, therapeutic
range between 50-100 µg/mL, prescribed predominantly in migraine prophylaxis,
epilepsy and psychiatric disorders. Careful clinical monitoring should be
performed during the first 6 months of therapy with valproic acid. For this
purpose, using uncertainty value is a good practice to interpret of patient
result.
Laboratories should calculate measurement uncertainity and evaluate
results according to spesific criterias.
References
- Gamze AVCİOGLU, Serpil ERDOGAN, Ceylan BAL, Orhan SEN, Pervin BARAN, Ozcan EREL
- Ataturk Training and Research Hospital, Department of Clinical Biochemistry, Ankara, Turkey Yildirim Beyazit University Faculty of Medicine, Department of Public Health, Ankara, Turkey
Abstract
References
- Gamze AVCİOGLU, Serpil ERDOGAN, Ceylan BAL, Orhan SEN, Pervin BARAN, Ozcan EREL
- Ataturk Training and Research Hospital, Department of Clinical Biochemistry, Ankara, Turkey Yildirim Beyazit University Faculty of Medicine, Department of Public Health, Ankara, Turkey
Details
| Journal Section | Articles |
|---|---|
| Authors | |
| Publication Date | February 16, 2017 |
| Published in Issue | Year 2017 Volume: Volume 2 Issue: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology |
