EVALUATING MEASUREMENT UNCERTAINTY OF PHENYTOIN

Year 2017, Volume: Volume 2 Issue: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 266 - 266, 16.02.2017

Cemil Nural Serpil Erdogan Ceylan Bal Orhan Sen Pervin Baran Ozcan Erel

Abstract

Measurement
uncertainty is a quality parameter for the accuracy of the measurement results
in clinical testing. It shows what extent the result represents the real value.
Measurement uncertainty is very important for the clinician to provide medical
decision, diagnosis and treatment. The purpose of this study is to calculate
measurement uncertainty of phenytoin by using internal quality control datas,
inter laboratory comparison results and calibrator uncertainty value to compare
it with CLIA total error % (TEa%) value.

Between march
2015 and March 2016, the internal quality control datas were screened. The
estimation of phenytoin measurement was calculated according to ISO21748 guide.
Inter laboratory comparison and calibrator uncertainty values were used to
estimate bias. Phenytoin levels were determined using the immunoturbidimetric
method on the Roche Cobas Integra 800 analyzer.

TEa% values for
phenytoin was 19,47. This value was not higher than CLIA (%25).

Discussion:
Phenytoin is primary antiepileptic agent in all types of epilepsy except
absence epilepsy Dosage adjustment is important for assessment treatment efficacy
in therapeutic range and also protection from the negative health effects in
toxic levels. Therefore, medical laboratories should produce analytically
reliable results for the correct interpretation and use of results.

Laboratories
should give results lower than TEa% limits for phenytoin.

Keywords

EVALUATING MEASUREMENT UNCERTAINTY OF PHENYTOIN

References

• Cemil NURAL, Serpil ERDOGAN , Ceylan BAL , Orhan SEN , Pervin BARAN , Ozcan EREL
• Ataturk Training and Research Hospital, Department of Clinical Biochemistry, Ankara, Turkey Yildirim Beyazit University Faculty of Medicine, Department of Public Health, Ankara, Turkey