THE EFFECT OF QUITTING SMOKING ON OXIDATIVE STRESS PARAMETERS

Year 2017, Volume: Volume 2 Issue: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 269 - 269, 16.02.2017

Bicer Cemile Yuksel Sevda Cucen Zubeyde Sengezer Tijen

Abstract

Deterious
effects of smoking in smokers has consistently been observed when compared with
healthy controls. Better evidence of quitting effects comes from within-subject
changes. In our study we examined the changes in oxidative stress parameters;
total antioxidant status (TAS), total oxidant status (TOS), total thiol (-SH),
paraoxonase (PON-1) and arylesterase (ARE) in smokers before and after
quitting.

50 smokers who
applied to Ankara Numune Training and Research Hospital, Family Medicine Clinic
and Smoking Cessation Center were participated in the study. 30 of smokers who
succeeded in maintaining 3 months quitting were enrolled in the study. Blood
TAS, TOS levels and PON, ARE activities were measured before and after
quitting.

Serum TOS levels
were significantly decreased (p<0.001) and ARE activities were significantly
increased (p=0.002) after quitting. The changes in TAS, -SH levels and PON
activity were statistically insignificant.

Quitting smoking
has decreased oxidative stress and increased antioxidant capacity even after 3
months of quitting period.

Keywords

THE EFFECT OF QUITTING SMOKING ON OXIDATIVE STRESS PARAMETERS

References

• Bicer CEMİLE, Yuksel SEVDA, Cucen ZUBEYDE, Sengezer TİJEN
• Yıldırım Beyazıt University, Faculty of Medicine, Biochemistry Department Turgut Özal University, Ankara School of Health Sciences, Child Development Department Turgut Özal University, Ankara Vocational School of Health Services 4. Ankara Numune Training and Research Hospital, Family Medicine Clinic and Smoking Cessation Center