DETERMINATION OF PSYCHOACTIVE SUBSTANCES IN TEN SALVIA SPECIES FROM TURKEY

Year 2017, Volume: Volume 2 Issue: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 301 - 301, 16.02.2017

Seda Damla Hatipoglu Burhanettin Yalcinkaya Muslum Akgoz Turan Ozturk Gulacti Topcu Ahmet C. Goren

Abstract

Salvia divinorum
(Epling and Javita), a member of the family of Lamiaceae (Labiatae), is endemic
of the northern Sierra Mazateca maountain of Mexico. It was used by Mazatec
Indians in spiritual rituals for its hallucinatory effects. Although these
effects were known for long time, the molecules providing the effects were
isolated quite later from S. divinorum leaves, the first compounds of which
were neoclerodane diterpene salvinorin A and B. Salvinorin A was found to be a
potent agonist toward κ-opioid receptor (KOR). On the other hand, salvinorin B,
which is a metabolite of Salvinorin A through an ester hydrolysis, was inactive
at KOR. In this study, 10 different Salvinorin A and B, belonging to Salvia
species in Turkey were investigated, applying two methods such as LC-MS/MS and
qPCR and the which having hallucinatory effects were determined. Moreover, this
study was aimed at formulating the phylogenetic tree of the species having
similar gene sequences. Salvinorin A and B were found to be in between trace to
21.89±1.83 mg/kg and trace to 45.40±3.59 mg/kg, respectively, in Salvia species
in Anatolia, Turkey. 

Keywords

DETERMINATION OF PSYCHOACTIVE SUBSTANCES IN TEN SALVIA SPECIES FROM TURKEY

References

• Seda Damla HATİPOGLU, Burhanettin YALCİNKAYA, Muslum AKGOZ, Turan OZTURK, Gulacti TOPCU, Ahmet C. GOREN
• Department of Chemistry, Faculty of Science and Letters, Istanbul Technical University, 34469, Istanbul, Turkey TÜBİTAK, UME, Chemistry Group Laboraties, P.O. Box 54 41470 Gebze-Kocaeli, Turkey Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Bezmialem Vakıf University, Istanbul, Turkey