Evaluation of solvent exposure of patients admitted to Ankara Occupational and Environmental Diseases Hospital in 2006

Year 2017, Volume 2, Issue 1(4), 26 - 26, 01.11.2017

Murat Büyükşekerci Ceylan Bal Cemil Nural Ömer Hınç Yılmaz

Abstract

Aim:
The aim of this study was to evaluate the urinary solvent levels of patients
admitted to Ankara Occupational and Environmental Diseases Hospital in 2006

Method: The urinary metabolite levels of solvents of the workers referred to
our hospital for periodical medical examination between January 2016 and
December 2016 were assessed as biomarkers of exposure i.e.; hippuric acid for
toluene exposure, mandelic acid and phenylglyoxylic acid for styrene exposure,
1 hydroxypyrene for poly aromatic hydrocarbons exposure and trichloroacetic
acid for trichloroethylene exposure.

Findings: The number of patients whose urinary trichloro acetic acid level
monitored was 2228 and %5 (n=123) of them exceeded reference value (<10
mg/L) of our laboratory. The mean trichloro acetic acid value of all patients
was 4,86 mg/L. The number of patients whose urinary mandelic acid level
monitored was 1141 and % 2 (n=27) of them exceeded reference value ((<400
mg/L).. The mean mandelic acid value of all patients was 144,37 mg/L. The
number of patients whose urinary hippuric acid level monitored was 1849 and % 6
(n=107) of them exceeded reference value (<1500 mg/L). The mean hippuric
acid value of all patients was 654,72 mg/L. The number of patients whose
urinary phenylglyoxylic acid level monitored was 1131 and % 1 (n=15) of them
exceeded reference value (0-100 mg/L). The mean phenylglyoxylic acid value of
all patients was 21,78 mg/L. The number of patients whose urinary 1
hydroxypyrene level monitored was 1557 and % 4 (n=60) of them exceeded
reference value (<1400 mg/L). The mean 1 hydroxypyrene value of all patients
was 456,58 mg/L.

Conclusion: We conclude that toluene was the most common solvent to exceeded
reference value in occupationally exposed workers and trichloroethylene and
poly aromatic hydrocarbons were other solvents following toluene.

 

Keywords:
solvent,
occupational exposure, toluene

Keywords

Evaluation of solvent exposure of patients admitted to Ankara Occupational and Environmental Diseases Hospital in 2006

References

• Murat Büyükşekerci1, Ceylan Bal2, Cemil Nural2, Ömer Hınç Yılmaz3 1Department of Pharmacology, Occupational Diseases Hospital, Ankara, Turkey 2Department of Biochemistry, Yıldırım Beyazıt University, Ankara, Turkey 3Department of Public Health, Yıldırım Beyazıt University, Ankara, Turkey