Demographic and histopathological analysis of malignant mesothelioma cases diagnosed at two different provinces in Turkey

Year 2017, Volume 2, Issue 1(4), 53 - 53, 01.11.2017

Sevinç Şahin Serdar Yanık Vugar Ali Türksoy Melike Nalbant Moray Şafak Atahan Betül Aytekin

Abstract

Objective: We aimed
to evaluate and compare the demographic and histopathological features of
malignant mesothelioma (MM) cases diagnosed in two different provinces in
Turkey.

Methods: The
demographic and histopathological characteristics of MM cases diagnosed at
Pathology Department, Bozok University School of Medicine, and Private Bursa
Patonet Laboratory were investigated retrospectively.

Results: There were
15 cases of MM diagnosed at Bozok University School of Medicine. Six(40%) patients
were female, 9(60%) were male. The age ranged from 40 to 82 (mean=67.6±10.86)
years. The anatomic location of 13(86.7%) cases were pleura, 1(6.7%) was
scrotum and 1(6.7%) was omentum. 
Histopathologically, 12 pleural mesotheliomas showed epithelioid subtype
and 1 showed sarcomatoid subtype. The omental mesothelioma exhibited
epithelioid subtype and scrotal mesothelioma exhibited biphasic subtype. Five
cases were smokers. Two cases had asbestos exposure. Four cases were
housewives, 3 were farmers and 2 were construction workers. All cases were born
and resided in Yozgat. Distribution of cases according to districts are as
follows in a descending order of frequency; Sorgun, Cekerek, Central district,
Akdagmadeni, and Kadısehri [5(33.3%), 5(33.3%), 2(13.4%), 2(13.4%), and 1(6.6%)
cases, respectively].

There
were 3 patients diagnosed as MM at Private Bursa Patonet Laboratory. 2(66.6%)
of these patients were male, 1(33.4%) of was female. The mean age of the
patients was 70.33±7.57 years (range:65-79). All cases were located in the
pleura. Histologically, 2 cases were epithelioid subtype, and 1 was
desmoplastic subtype.

Results: In the
literature male/female ratio of MM is 4/1, however this ratio was lower in our
study. Similar to the literature, pleura was the most frequent site of MM, and
the most frequent histologic subtype was the epithelioid variant. In Yozgat, MM
was more frequently seen in Sorgun and Cekerek compared to other districts. In
order to elucidate the causes of this geographical distribution, comprehensive
etiological studies are needed.

 

Keywords:
mesothelioma, pleura, epithelioid, sarcomatoid, asbestos, Yozgat

Keywords

Demographic and histopathological analysis of malignant mesothelioma cases diagnosed at two different provinces in Turkey

References

• (1) Sevinç Şahin, Department of Pathology, Bozok University School of Medicine, Yozgat (2) Serdar Yanık, Department of Pathology, Bozok University School of Medicine, Yozgat (3) Vugar Ali Türksoy,Department of Public Health, Bozok University School of Medicine, Yozgat (4) Melike Nalbant Moray, Prof. Dr. Turkan Akyol Chest Diseases Hospital, Bursa (5) Şafak Atahan, Department of Pathology, Biruni University School of Medicine, Istanbul (6) Betül Aytekin, Department of Pathology, Bozok University School of Medicine, Yozgat