Pulpitis Models in Experimental Animal Studies: A Traditional Review

Yıl 2024, , 329 - 343, 10.05.2024

Burcu Pirimoglu , Cangül Keskin , Abdurrahman Aksoy

https://doi.org/10.58711/turkishjdentres.vi.1378430

Öz

Animal experiments are the controlled use of animals in scientific studies in line with ethical principles. Using subjects in experimental in vivo research is a must; therefore, experimental animals have become an alternative to human subjects. They provide limited information due to the fact that the data obtained from in vitro experiments are far from clinical applications. A well-designed animal experiment provides the basis for future clinical trials in humans. Animal experiments have made important contributions to science in gaining knowledge about diseases, testing a new drug or surgical technique. Animal models have been used in many studies in the field of dentistry, especially in the field of endodontics. In order
to carry out these studies, first of all, an appropriate animal model and ethical principles and the results to be obtained must be adaptable. Since there is no single animal model that demonstrates all aspects of dental anomalies, morphology, disease process and healing, specific models are often used that
provide information about disease and treatment mechanisms. In dental research, monkeys, dogs, rabbits, sheep, pigs, ferrets, rats and mice are used for animal models. The aim of the study,
the hypothesis, the analysis techniques to be applied, and the animal model to which the results can be adapted for human should be selected. The welfare of the experimental animals used in the study must comply with the laws and regulations and it must be ensured that the animals are not exposed to
unnecessary pain and distress. In this review, the selection of the animal model, the operation of the study and the application of ethical rules while planning an animal model research in the field of endodontics are discussed.

Anahtar Kelimeler

Animal Experiments, Pulpitis Models, Endodontics

Deneysel Hayvan Çalışmalarında Pulpitis Modelleri: Geleneksel Derleme

Öz

Hayvan deneyleri, hayvanların bilimsel çalışmalarda etik ilkeler doğrultusunda kontrollü olarak kullanılmasıdır. Deneysel in vivo araştırmalarda denek kullanmak bir zorunluluktur; bu yüzden deney hayvanları insan deneklere bir alternatif olmuştur. In vitro deneyler ile elde edilen verilerin klinik uygulamalardan uzak olması sebebiyle sınırlı bilgi sağlarlar. İyi tasarlanmış bir hayvan deneyi, insanlarda gelecekteki klinik deneyler için temel bilgiler sağlar. Hayvan deneyleri, hastalıklar hakkında bilgi edinilmesinde, yeni bir ilaç veya cerrahi tekniğin test edilmesinde bilime önemli katkılar sağlamıştır. Diş hekimliği alanında, özelikle de endodonti alanında da birçok çalışmada hayvan modelleri kullanılmıştır. Bu çalışmaların yapılabilmesi için öncellikli olarak uygun bir hayvan modeli ve etik ilkeler ile
elde edilecek sonuçların uyarlanabilir olması gerekir. Dental anomalilerin, morfolojinin, hastalık süreci ve iyileşmesinin tüm yönlerini gösteren tek bir hayvan modeli olmadığı için, genellikle hastalık ve tedavi mekanizmaları hakkında bilgi sağlayan spesifik modeller kullanılmaktadır. Diş hekimliği araştırmalarında, maymun, köpek, tavşan, koyun, domuz, gelincik, sıçan ve fareler hayvan modelleri için kullanılmaktadır.
Çalışmanın amacı, hipotezi, uygulanacak analiz teknikleri ve elde edilecek sonuçların insan için uyarlanabileceği hayvan modeli seçilmelidir. Çalışmada kullanılan deney hayvanlarının refahı, yasa ve yönetmeliklerine uygun olmalıdır ve hayvanların gereksiz acı ve sıkıntıya maruz kalmaması sağlanmalıdır. Bu derlemede, endodonti alanında hayvan modeli araştırması planlanırken hayvan modelinin seçimi, çalışmanın işleyişi ve etik kuralların uygulanması ele alınmıştır

Anahtar Kelimeler

hayvan deneyleri, pulpitis modelleri, endodonti

Kaynakça

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