Odontojenik Keratokistlerde Farklı Tedavi Yaklaşımları ve Takip Sonuçlarının Retrospektif Olarak Değerlendirilmesi
Yıl 2024,
Cilt: 3 Sayı: 1, 308 - 316, 10.05.2024
Kübra Uğurlu
,
Nilüfer Özkan
,
Emel Bulut
Öz
Amaç: Odontojenik keratokistler (OKK); lokal agresif özellikleri ve yüksek nüks etme oranları ile karakterize
odontojenik kistlerdir. Bu çalışmada; OKK’lerin demografik özellikleri, tedavi sonuçları ve nüks oranlarının incelenmesi hedeflenmektedir.
Gereç ve Yöntem: Bu çalışma; Ondokuz Mayıs Üniversitesi Diş Hekimliği Fakültesi Ağız, Diş ve Çene Cerrahisi Anabilim Dalı’nda yürütülmüştür. Çalışmaya OKK tanısı konulan 19 hasta dahil edilmiştir. Hastaların; yaş, cinsiyet, lezyonun lokalizasyonu, uygulanan cerrahi tedavi yöntemleri, nüks varlığı ve takip süreleri retrospektif olarak incelenmiştir.
Bulgular: İncelenen hastaların yaş aralığı 8-79 yıl aralığında olup ortalama yaşları 38,7’dir. 19 hastanın 14’ü
kadın, 5’i ise erkektir. İncelenen 20 lezyondan 11’i multiloküler, 9’u ise uniloküler radyografik görünümdedir. Lezyonların 18’i mandibular posterior bölgede tespit edilmiştir. Tedavi yöntemleri olarak enükleasyon ve küretaj öne çıkmış, bazı vakalarda ise lezyon boyutlarının küçültülmesi amacıyla dekompresyon tedavisine başvurulmuştur. Tedavisi tamamlanan 16 hastanın 3’ünde nüks geliştiği tespit edilmiştir. Takip süreleri 5 ila 120 ay arasında değişkenlik göstermektedir.
Sonuç: Odontojenik keratokistlerin tedavisinde kullanılan yöntemlerin dikkatle seçilmesi ve hastaların uzun süreli klinik ve radyografik olarak takip edilmesi, tedavi başarısı üzerinde önemli bir etkiye sahiptir.
Etik Beyan
Bu araştırma, Ondokuz Mayıs Üniversitesi Klinik Araştırmalar Etik Kurulu tarafından 05.03.2024 tarihli 2024/92 karar numarası ile etik onayı almış ve Helsinki Deklarasyonu Prensipleri’ne uygun olarak yapılmıştır.
Kaynakça
- Stoelinga P. The odontogenic keratocyst revisited.
International Journal of Oral and Maxillofacial Surgery.
2022;51(11):1420-3.
- Reichart PA, Philipsen HP, Sciubba JJ. The new
classification of head and neck tumours (WHO)—any
changes? Oral oncology. 2006;8(42):757-8.
- Kaczmarzyk T, Stypułkowska J, Tomaszewska R. Update
of the WHO classification of odontogenic and maxillofacial
bone tumours. Journal of Stomatology. 2017;70(5):484-
506.
- Soluk-Tekkesin M, Wright JM. The World Health
Organization classification of odontogenic lesions: a
summary of the changes of the 2022 (5th) edition. Turkish
Journal of Pathology. 2022;38(2):168.
- Pitak-Arnnop P, Chaine A, Oprean N, Dhanuthai K,
Bertrand J-C, Bertolus C. Management of odontogenic
keratocysts of the jaws: a ten-year experience with 120
consecutive lesions. Journal of Cranio-Maxillofacial
Surgery. 2010;38(5):358-64.
- Chirapathomsakul D, Sastravaha P, Jansisyanont P. A
review of odontogenic keratocysts and the behavior of
recurrences. Oral surgery, oral medicine, oral pathology,
oral radiology, and endodontology. 2006;101(1):5-9.
- Habibi A, Saghravanian N, Habibi M, Mellati E, Habibi M.
Keratocystic odontogenic tumor: a 10-year retrospective
study of 83 cases in an Iranian population. Journal of oral
science. 2007;49(3):229-35.
- Myoung H, Hong S-P, Hong S-D, Lee J-I, Lim C-Y,
Choung P-H, et al. Odontogenic keratocyst: review of 256
cases for recurrence and clinicopathologic parameters. Oral
Surgery, Oral Medicine, Oral Pathology, Oral Radiology,
and Endodontology. 2001;91(3):328-33.
- Pogrel M. The keratocystic odontogenic tumor. Oral and
Maxillofacial Surgery Clinics. 2013;25(1):21-30.
- Titinchi F, Nortje CJ. Keratocystic odontogenic tumor: a
recurrence analysis of clinical and radiographic parameters.
Oral Surgery, Oral Medicine, Oral Pathology and Oral
Radiology. 2012;114(1):136-42.
- Morgan TA, Burton CC, Qian F. A retrospective review of
treatment of the odontogenic keratocyst. Journal of oral and
maxillofacial surgery. 2005;63(5):635-9.
- Mendes RA, Carvalho JF, van der Waal I. Biological
pathways involved in the aggressive behavior of the
keratocystic odontogenic tumor and possible implications
for molecular oriented treatment–an overview. Oral
oncology. 2010;46(1):19-24.
- Singh AK, Khanal N, Chaulagain R, Bhujel N, Singh
RP. How effective is 5-Fluorouracil as an adjuvant in the
management of odontogenic keratocyst? A systematic
review and meta-analysis. British Journal of Oral and
Maxillofacial Surgery. 2022;60(6):746-54.
- Madras J, Lapointe H. Keratocystic odontogenic tumour:
reclassification of the odontogenic keratocyst from cyst
to tumour. Journal of the Canadian Dental Association.
2008;74(2).
- Roopak B, Singh M, Shah A, Patel G. Keratocystic
odontogenic tumor: treatment modalities: study of 3 cases.
Nigerian Journal of Clinical Practice. 2014;17(3):378-83.
- Brannon RB. The odontogenic keratocyst: A
clinicopathologic study of 312 cases. Part I. Clinical
features. Oral Surgery, Oral Medicine, Oral Pathology.
1976;42(1):54-72.
- Kinard BE, Chuang S-K, August M, Dodson TB. How well
do we manage the odontogenic keratocyst? Journal of Oral
and Maxillofacial Surgery. 2013;71(8):1353-8.
- Kocakahyaoğlu B, Çetiner S. Odontojenik keratokistlerin
tanı ve tedavisinde güncel yaklaşımlar. Gazi Üniversitesi
Diş Hekimliği Fakültesi Dergisi. 2007;24(2):119-23.
- Gang T-I, Huh K-H, Yi W-J, Heo M-S, Lee S-S, Kim
J-H, et al. Diagnostic ability of differential diagnosis in
ameloblastoma and odontogenic keratocyst by imaging
modalities and observers. Imaging Science in Dentistry.
2006;36(4):177-82.
- Boffano P, Ruga E, Gallesio C. Keratocystic odontogenic
tumor (odontogenic keratocyst): preliminary retrospective
review of epidemiologic, clinical, and radiologic features
of 261 lesions from University of Turin. Journal of oral and
maxillofacial surgery. 2010;68(12):2994-9.
- Jung H-D, Lim J-H, Kim HJ, Nam W, Cha I-H. Appropriate
follow-up period for odontogenic keratocyst: a retrospective
study. Maxillofacial plastic and reconstructive surgery.
2021;43:1-6.
- Blanchard SB. Odontogenic keratocysts: review of the
literature and report of a case. Journal of periodontology.
1997;68(3):306-11.
- Abdullah WA. Surgical treatment of keratocystic
odontogenic tumour: A review article. The Saudi dental journal. 2011;23(2):61-5.
- Zhao Y-F, Wei J-X, Wang S-P. Treatment of odontogenic
keratocysts: a follow-up of 255 Chinese patients. Oral
Surgery, Oral Medicine, Oral Pathology, Oral Radiology,
and Endodontology. 2002;94(2):151-6.
- El-Hajj G, Anneroth G. Odontogenic keratocysts—a
retrospective clinical and histologic study. International
journal of oral and maxillofacial surgery. 1996;25(2):124-9.
- Chuong R, Donoff RB, Guralnick W. The odontogenic
keratocyst. Journal of Oral and Maxillofacial Surgery.
1982;40(12):797-802.
- Pogrel MA. Treatment of keratocysts: the case for
decompression and marsupialization. Journal of oral and
maxillofacial surgery. 2005;63(11):1667-73.
- Tolstunov L, Treasure T. Surgical treatment algorithm
for odontogenic keratocyst: combined treatment of
odontogenic keratocyst and mandibular defect with
marsupialization, enucleation, iliac crest bone graft, and
dental implants. Journal of Oral and maxillofacial Surgery.
2008;66(5):1025-36.
- Brøndum N, Jensen VJ. Recurrence of keratocysts and
decompression treatment: a long-term follow-up of fortyfour
cases. Oral surgery, oral medicine, oral pathology.
1991;72(3):265-9.
- Marker P, Brøndum N, Pr P, Bastian HL. Treatment of
large odontogenic keratocysts by decompression and later
cystectomy: a long-term follow-up and a histologic study
of 23 cases. Oral Surgery, Oral Medicine, Oral Pathology,
Oral Radiology, and Endodontology. 1996;82(2):122-31.
- Pogrel MA, Jordan R. Marsupialization as a definitive
treatment for the odontogenic keratocyst. Journal of oral
and maxillofacial surgery. 2004;62(6):651-5.
- Maurette PE, Jorge J, de Moraes M. Conservative treatment
protocol of odontogenic keratocyst: a preliminary study.
Journal of oral and maxillofacial surgery. 2006;64(3):379-
83.
- Loescher A, Robinson P. The effect of surgical medicaments
on peripheral nerve function. British Journal of Oral and
Maxillofacial Surgery. 1998;36(5):327-32.
- Hellstein J, Hopkins T, Morgan T. The history and
mystery of Carnoy solution: an assessment of the need for
chloroform. Oral Surgery, Oral Medicine, Oral Pathology,
Oral Radiology and Endodontology. 2007;4(103):e24.
- Janas-Naze A, Zhang W, Szuta M. Modified Carnoy’s
Versus Carnoy’s Solution in the Management of
Odontogenic Keratocysts—A Single Center Experience.
Journal of Clinical Medicine. 2023;12(3):1133.
- Dashow JE, McHugh JB, Braun TM, Edwards SP, Helman
JI, Ward BB. Significantly decreased recurrence rates in
keratocystic odontogenic tumor with simple enucleation
and curettage using Carnoy’s versus modified Carnoy’s
solution. Journal of Oral and Maxillofacial Surgery.
2015;73(11):2132-5.
- Longley DB, Harkin DP, Johnston PG. 5-fluorouracil:
mechanisms of action and clinical strategies. Nature
reviews cancer. 2003;3(5):330-8.
- Ledderhof NJ, Caminiti MF, Bradley G, Lam DK. Topical
5-fluorouracil is a novel targeted therapy for the keratocystic
odontogenic tumor. Journal of Oral and Maxillofacial
Surgery. 2017;75(3):514-24.
- Melean LP, Guerrero LM, Lopez L. 5-fluorouacil in
the treatment of odontogenic keratocysts—incidence
of recurrence and inferior alveolar nerve paresthesia:
a systematic review. Oral and Maxillofacial Surgery.
2023;27(3):489-96.
- Emmings F, Neiders M, Greene Jr G, Koepf S, Gage
A. Freezing the mandible without excision. Journal
of oral surgery (American Dental Association: 1965).
1966;24(2):145-55.
- Schmidt BL. The use of liquid nitrogen cryotherapy in
the management of the odontogenic keratocyst. Oral and
Maxillofacial Surgery Clinics. 2003;15(3):393-405.
- Zhou J, Jiao S, Chen X, Wang Y. Treatment of recurrent
odontogenic keratocyst with enucleation and cryosurgery:
a retrospective study of 10 cases. Shanghai kou Qiang yi
xue= Shanghai Journal of Stomatology. 2005;14(5):476-8.
- Pogrel MA. The use of liquid nitrogen cryotherapy in the
management of locally aggressive bone lesions. Journal
of oral and maxillofacial surgery: official journal of the
American Association of Oral and Maxillofacial Surgeons.
1993;51(3):269-73.
- Blanas N, Freund B, Schwartz M, Furst IM. Systematic
review of the treatment and prognosis of the odontogenic
keratocyst. Oral Surgery, Oral Medicine, Oral Pathology,
Oral Radiology, and Endodontology. 2000;90(5):553-8.
- Al-Moraissi EA, Dahan AA, Alwadeai MS, Oginni FO,
Al-Jamali JM, Alkhutari AS, et al. What surgical treatment
has the lowest recurrence rate following the management
f keratocystic odontogenic tumor?: A large systematic
review and meta-analysis. Journal of Cranio-Maxillofacial
Surgery. 2017;45(1):131-44.
- Ortakoğlu K, Köymen R, Karasu H, Doğan N. Gorlin
Goltz sendromu (Bazal hücreli nevus sendromu)(İki olgu
nedeniyle). T Klin Diş Hek Bil. 2000;6:168-73.
- Timoçin N, Doğan Ö. Gorlin-Goltz Sendromu Olgu
Bildirisi. İstanbul Üniversitesi Diş Hekimliği Fakültesi
Dergisi. 1994;28(1):53-6.
- González-Alva P, Tanaka A, Oku Y, Yoshizawa D, Itoh
S, Sakashita H, et al. Keratocystic odontogenic tumor: a
retrospective study of 183 cases. Journal of oral science.
2008;50(2):205-12.
- Crowley TE, Kaugars GE, Gunsolley JC. Odontogenic
keratocysts: a clinical and histologic comparison of the
parakeratin and orthokeratin variants. Journal of Oral and
Maxillofacial Surgery. 1992;50(1):22-6.
- Lam K, L. Chan AC. Odontogenic keratocysts: a
clinicopathological study in Hong Kong Chinese. The
Laryngoscope. 2000;110(8):1328-32.
Retrospective Evaluation of Different Treatment Approaches and Follow-up Outcomes in Odontogenic Keratocysts
Yıl 2024,
Cilt: 3 Sayı: 1, 308 - 316, 10.05.2024
Kübra Uğurlu
,
Nilüfer Özkan
,
Emel Bulut
Öz
Aim: Odontogenic keratocysts (OCCs) are odontogenic cysts characterised by locally aggressive features and high recurrence rates. The aim of this study is to investigate the demographic characteristics, treatment results and recurrence rates of OCCs.
Material and Method: This study was conducted in the Department of Oral and Maxillofacial Surgery at Ondokuz Mayıs University Faculty of Dentistry. The study included nineteen patients diagnosed with OCCs. Age, gender, localization of the lesion, surgical treatment methods, presence of recurrence and follow-up periods of the patients were retrospectively analysed.
Results: The age range of the patients was 8-79 years with a mean age of 38.7 years. 14 of 19 patients were female and 5 were male. Of the 20 lesions, 11 were multilocular and 9 were unilocular radiographically. The mandibular posterior region revealed 18 of the lesions. Enucleation and curettage
were the most common treatment modalities, and in some cases decompression therapy was used to reduce the size of the lesions. Recurrence was detected in 3 of 16 patients whose treatment was completed. Follow-up periods varied between 5 and 120 months.
Conclusion: Careful selection of the methods used in the treatment of odontogenic keratocysts and long-term clinical and radiographic follow-up of patients have a significant effect on treatment success.
Kaynakça
- Stoelinga P. The odontogenic keratocyst revisited.
International Journal of Oral and Maxillofacial Surgery.
2022;51(11):1420-3.
- Reichart PA, Philipsen HP, Sciubba JJ. The new
classification of head and neck tumours (WHO)—any
changes? Oral oncology. 2006;8(42):757-8.
- Kaczmarzyk T, Stypułkowska J, Tomaszewska R. Update
of the WHO classification of odontogenic and maxillofacial
bone tumours. Journal of Stomatology. 2017;70(5):484-
506.
- Soluk-Tekkesin M, Wright JM. The World Health
Organization classification of odontogenic lesions: a
summary of the changes of the 2022 (5th) edition. Turkish
Journal of Pathology. 2022;38(2):168.
- Pitak-Arnnop P, Chaine A, Oprean N, Dhanuthai K,
Bertrand J-C, Bertolus C. Management of odontogenic
keratocysts of the jaws: a ten-year experience with 120
consecutive lesions. Journal of Cranio-Maxillofacial
Surgery. 2010;38(5):358-64.
- Chirapathomsakul D, Sastravaha P, Jansisyanont P. A
review of odontogenic keratocysts and the behavior of
recurrences. Oral surgery, oral medicine, oral pathology,
oral radiology, and endodontology. 2006;101(1):5-9.
- Habibi A, Saghravanian N, Habibi M, Mellati E, Habibi M.
Keratocystic odontogenic tumor: a 10-year retrospective
study of 83 cases in an Iranian population. Journal of oral
science. 2007;49(3):229-35.
- Myoung H, Hong S-P, Hong S-D, Lee J-I, Lim C-Y,
Choung P-H, et al. Odontogenic keratocyst: review of 256
cases for recurrence and clinicopathologic parameters. Oral
Surgery, Oral Medicine, Oral Pathology, Oral Radiology,
and Endodontology. 2001;91(3):328-33.
- Pogrel M. The keratocystic odontogenic tumor. Oral and
Maxillofacial Surgery Clinics. 2013;25(1):21-30.
- Titinchi F, Nortje CJ. Keratocystic odontogenic tumor: a
recurrence analysis of clinical and radiographic parameters.
Oral Surgery, Oral Medicine, Oral Pathology and Oral
Radiology. 2012;114(1):136-42.
- Morgan TA, Burton CC, Qian F. A retrospective review of
treatment of the odontogenic keratocyst. Journal of oral and
maxillofacial surgery. 2005;63(5):635-9.
- Mendes RA, Carvalho JF, van der Waal I. Biological
pathways involved in the aggressive behavior of the
keratocystic odontogenic tumor and possible implications
for molecular oriented treatment–an overview. Oral
oncology. 2010;46(1):19-24.
- Singh AK, Khanal N, Chaulagain R, Bhujel N, Singh
RP. How effective is 5-Fluorouracil as an adjuvant in the
management of odontogenic keratocyst? A systematic
review and meta-analysis. British Journal of Oral and
Maxillofacial Surgery. 2022;60(6):746-54.
- Madras J, Lapointe H. Keratocystic odontogenic tumour:
reclassification of the odontogenic keratocyst from cyst
to tumour. Journal of the Canadian Dental Association.
2008;74(2).
- Roopak B, Singh M, Shah A, Patel G. Keratocystic
odontogenic tumor: treatment modalities: study of 3 cases.
Nigerian Journal of Clinical Practice. 2014;17(3):378-83.
- Brannon RB. The odontogenic keratocyst: A
clinicopathologic study of 312 cases. Part I. Clinical
features. Oral Surgery, Oral Medicine, Oral Pathology.
1976;42(1):54-72.
- Kinard BE, Chuang S-K, August M, Dodson TB. How well
do we manage the odontogenic keratocyst? Journal of Oral
and Maxillofacial Surgery. 2013;71(8):1353-8.
- Kocakahyaoğlu B, Çetiner S. Odontojenik keratokistlerin
tanı ve tedavisinde güncel yaklaşımlar. Gazi Üniversitesi
Diş Hekimliği Fakültesi Dergisi. 2007;24(2):119-23.
- Gang T-I, Huh K-H, Yi W-J, Heo M-S, Lee S-S, Kim
J-H, et al. Diagnostic ability of differential diagnosis in
ameloblastoma and odontogenic keratocyst by imaging
modalities and observers. Imaging Science in Dentistry.
2006;36(4):177-82.
- Boffano P, Ruga E, Gallesio C. Keratocystic odontogenic
tumor (odontogenic keratocyst): preliminary retrospective
review of epidemiologic, clinical, and radiologic features
of 261 lesions from University of Turin. Journal of oral and
maxillofacial surgery. 2010;68(12):2994-9.
- Jung H-D, Lim J-H, Kim HJ, Nam W, Cha I-H. Appropriate
follow-up period for odontogenic keratocyst: a retrospective
study. Maxillofacial plastic and reconstructive surgery.
2021;43:1-6.
- Blanchard SB. Odontogenic keratocysts: review of the
literature and report of a case. Journal of periodontology.
1997;68(3):306-11.
- Abdullah WA. Surgical treatment of keratocystic
odontogenic tumour: A review article. The Saudi dental journal. 2011;23(2):61-5.
- Zhao Y-F, Wei J-X, Wang S-P. Treatment of odontogenic
keratocysts: a follow-up of 255 Chinese patients. Oral
Surgery, Oral Medicine, Oral Pathology, Oral Radiology,
and Endodontology. 2002;94(2):151-6.
- El-Hajj G, Anneroth G. Odontogenic keratocysts—a
retrospective clinical and histologic study. International
journal of oral and maxillofacial surgery. 1996;25(2):124-9.
- Chuong R, Donoff RB, Guralnick W. The odontogenic
keratocyst. Journal of Oral and Maxillofacial Surgery.
1982;40(12):797-802.
- Pogrel MA. Treatment of keratocysts: the case for
decompression and marsupialization. Journal of oral and
maxillofacial surgery. 2005;63(11):1667-73.
- Tolstunov L, Treasure T. Surgical treatment algorithm
for odontogenic keratocyst: combined treatment of
odontogenic keratocyst and mandibular defect with
marsupialization, enucleation, iliac crest bone graft, and
dental implants. Journal of Oral and maxillofacial Surgery.
2008;66(5):1025-36.
- Brøndum N, Jensen VJ. Recurrence of keratocysts and
decompression treatment: a long-term follow-up of fortyfour
cases. Oral surgery, oral medicine, oral pathology.
1991;72(3):265-9.
- Marker P, Brøndum N, Pr P, Bastian HL. Treatment of
large odontogenic keratocysts by decompression and later
cystectomy: a long-term follow-up and a histologic study
of 23 cases. Oral Surgery, Oral Medicine, Oral Pathology,
Oral Radiology, and Endodontology. 1996;82(2):122-31.
- Pogrel MA, Jordan R. Marsupialization as a definitive
treatment for the odontogenic keratocyst. Journal of oral
and maxillofacial surgery. 2004;62(6):651-5.
- Maurette PE, Jorge J, de Moraes M. Conservative treatment
protocol of odontogenic keratocyst: a preliminary study.
Journal of oral and maxillofacial surgery. 2006;64(3):379-
83.
- Loescher A, Robinson P. The effect of surgical medicaments
on peripheral nerve function. British Journal of Oral and
Maxillofacial Surgery. 1998;36(5):327-32.
- Hellstein J, Hopkins T, Morgan T. The history and
mystery of Carnoy solution: an assessment of the need for
chloroform. Oral Surgery, Oral Medicine, Oral Pathology,
Oral Radiology and Endodontology. 2007;4(103):e24.
- Janas-Naze A, Zhang W, Szuta M. Modified Carnoy’s
Versus Carnoy’s Solution in the Management of
Odontogenic Keratocysts—A Single Center Experience.
Journal of Clinical Medicine. 2023;12(3):1133.
- Dashow JE, McHugh JB, Braun TM, Edwards SP, Helman
JI, Ward BB. Significantly decreased recurrence rates in
keratocystic odontogenic tumor with simple enucleation
and curettage using Carnoy’s versus modified Carnoy’s
solution. Journal of Oral and Maxillofacial Surgery.
2015;73(11):2132-5.
- Longley DB, Harkin DP, Johnston PG. 5-fluorouracil:
mechanisms of action and clinical strategies. Nature
reviews cancer. 2003;3(5):330-8.
- Ledderhof NJ, Caminiti MF, Bradley G, Lam DK. Topical
5-fluorouracil is a novel targeted therapy for the keratocystic
odontogenic tumor. Journal of Oral and Maxillofacial
Surgery. 2017;75(3):514-24.
- Melean LP, Guerrero LM, Lopez L. 5-fluorouacil in
the treatment of odontogenic keratocysts—incidence
of recurrence and inferior alveolar nerve paresthesia:
a systematic review. Oral and Maxillofacial Surgery.
2023;27(3):489-96.
- Emmings F, Neiders M, Greene Jr G, Koepf S, Gage
A. Freezing the mandible without excision. Journal
of oral surgery (American Dental Association: 1965).
1966;24(2):145-55.
- Schmidt BL. The use of liquid nitrogen cryotherapy in
the management of the odontogenic keratocyst. Oral and
Maxillofacial Surgery Clinics. 2003;15(3):393-405.
- Zhou J, Jiao S, Chen X, Wang Y. Treatment of recurrent
odontogenic keratocyst with enucleation and cryosurgery:
a retrospective study of 10 cases. Shanghai kou Qiang yi
xue= Shanghai Journal of Stomatology. 2005;14(5):476-8.
- Pogrel MA. The use of liquid nitrogen cryotherapy in the
management of locally aggressive bone lesions. Journal
of oral and maxillofacial surgery: official journal of the
American Association of Oral and Maxillofacial Surgeons.
1993;51(3):269-73.
- Blanas N, Freund B, Schwartz M, Furst IM. Systematic
review of the treatment and prognosis of the odontogenic
keratocyst. Oral Surgery, Oral Medicine, Oral Pathology,
Oral Radiology, and Endodontology. 2000;90(5):553-8.
- Al-Moraissi EA, Dahan AA, Alwadeai MS, Oginni FO,
Al-Jamali JM, Alkhutari AS, et al. What surgical treatment
has the lowest recurrence rate following the management
f keratocystic odontogenic tumor?: A large systematic
review and meta-analysis. Journal of Cranio-Maxillofacial
Surgery. 2017;45(1):131-44.
- Ortakoğlu K, Köymen R, Karasu H, Doğan N. Gorlin
Goltz sendromu (Bazal hücreli nevus sendromu)(İki olgu
nedeniyle). T Klin Diş Hek Bil. 2000;6:168-73.
- Timoçin N, Doğan Ö. Gorlin-Goltz Sendromu Olgu
Bildirisi. İstanbul Üniversitesi Diş Hekimliği Fakültesi
Dergisi. 1994;28(1):53-6.
- González-Alva P, Tanaka A, Oku Y, Yoshizawa D, Itoh
S, Sakashita H, et al. Keratocystic odontogenic tumor: a
retrospective study of 183 cases. Journal of oral science.
2008;50(2):205-12.
- Crowley TE, Kaugars GE, Gunsolley JC. Odontogenic
keratocysts: a clinical and histologic comparison of the
parakeratin and orthokeratin variants. Journal of Oral and
Maxillofacial Surgery. 1992;50(1):22-6.
- Lam K, L. Chan AC. Odontogenic keratocysts: a
clinicopathological study in Hong Kong Chinese. The
Laryngoscope. 2000;110(8):1328-32.