Research Article
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Year 2019, Volume 1, Issue 1, 11.12.2019

Abstract

References

  • [1] Liu. Z., Wang, B., Yang, Z., Li, Y., Qin, D., Li, T. 2009. “Synthesis, crystal structure, DNA interaction and antioxidant activities of two novel water-soluble Cu(2þ) complexes derivated from 2-oxo-quinoline-3- carbaldehyde Schiff-bases“, Eur J Med Chem. 44, 4477-4484.
  • [2] Hussain, H., Babic, G., Durst, T., Wright, J., Flueraru, M., Chichirau, A., Chepelev, L.L.2003. “Development of Novel Antioxidants:  Design, Synthesis, and Reactivity“, Org. Chem. 6, 7023-7032.
  • [3] Ünver, Y., Sancak, K., Çelik, F., Birinci, E., Küçük, M., Soylu, S., Burnaz, N. A. 2014. “New thiophene-1,2,4-triazole-5(3)-ones: highly bioactive thiosemicarbazides, structures of schiff bases and triazole-thiols“, European Journal of Medicinal Chemistry 84, 639-650.
  • [4] Ünver, Y., Deniz, S., Çelik, F., Akar, Z., Küçük, M., Sancak, K. 2016. “Synthesis of New 1,2,4-Triazole Compounds Containing Schiff and Mannich Bases (Morpholine) with Antioxidant and Antimicrobial Activities“, Journal of Enzym İnhibition and Medicinal Chemistry 31(3S), 89-95.
  • [5] Ünver, Y., Bektaş, E. 2018. “Synthesis and biological activity of new Schiff bases of benzylideneamine bearing thiophene, 1,2,4-triazolone, 1,3,4-oxadiazole, morpholine moieties“, Letters in Drug Design & Discovery 15, 706-712.
  • [6] Ünver, Y., Bektaş, E., Direkel, Ş. 2018. “Synthesis And Antioxidant And Antileishmanial Activities of New Bis N-Amino Triazole Derivatives“, Russian Journal of General Chemistry 88, 2616-2620.
  • [7] Ünver, Y., Tuluk, M., Kahriman, N., Emirik,E., Bektaş, E., Direkel, Ş. 2019. “New Chalcone Derivatives With Schiff Base-Thiophene: Synthesis, Biological Activity And Molecular Docking Studies“, Russian Journal of General Chemistry 89, 794-799.
  • [8] Ünver, Y., Baş, H., Bıyıklıoğlu, Z. 2019. “Non-peripherally 4-{[(1E)-1-benzothien-2-ylmethylene]amino} phenol substituted zinc(II), manganese(III), cobalt(II) phthalocyanines:Synthesis and electrochemistry“, Journal of Molecular Structure 1178, 508-513.
  • [9] Serbest, K., Özen, A., Ünver, Y., Er, M., Değirmencioğlu, İ., Sancak, K. 2009. “Spectroscopic and theoretical study of 1,2,4-triazole-3-one based salicyaldimine complexes and evaluation of superoxide-scavenging propertie“, Journal of Molecular Structure 922, 1-10.
  • [10] Serbest, K., Değirmencioğlu, İ., Ünver, Y., Er, M., Kantar, C., Sancak, K. 2007. “Microwave-assisted synthesis and characterization and theorical calculations of the first example of free and metalo phthalocyanines from salen type Schiff base derivative bearing thiophen and triazole heterocyclic ring“, Journal of Organometallic Chemistry 692, 5646-5654.
  • [11] Avramova, P., Danchev, N., Buyukliev, R., Bogoslovova, T. 1998. “Synthesis, Toxicological, and Pharmacological Assessment of Derivatives of 2-Aryl-4-(3-arylpropyl)morpholines“, Arch Pharm. 331:342–346.
  • [12] Dhahagani, K.; Mathan Kumar, S.; Chakkaravarthi, G.; Anitha, K.; Rajesh, J.; Ramu, A.; Rajagopal, G. 2014. “Synthesis and spectral characterization of Schiff base complexes of Cu(II), Co(II), Zn(II) and VO(IV) containing 4-(4-aminophenyl)morpholine derivatives: Antimicrobial evaluation and anticancer studies“.Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy 117, 87-94.
  • [13] Benzie I.F.F., Szeto, Y.T. 1999. “Total Antioxidant Capacity of Teas by the Ferric Reducing/Antioxidant Power Assay“, J. Agric. Food Chem. 47(2), 633–636.

Schiff base derivatives with morpholine and antioxidant activity

Year 2019, Volume 1, Issue 1, 11.12.2019

Abstract

New Schiff base derivatives with morpholines, 4-bromo-2-(((4-morpholinophenyl)imino)methyl)phenol (I) and 4-bromo-2-(((2-morpholinoethyl) imino) methyl)phenol (II)   were synthezised. The compounds I- II were characterized by spectral methods IR, and NMR spectroscopic techniques. Antioxidant activities of compounds I and II were determined by the ferric reducing ability of plasma (FRAP) assay method which is based on the reduction of Fe3+ -TPTZ complex to the Fe2+ -TPTZ complex in the presence of antioxidants. Compound I has relatively high ferric reducing power ability (i.e., antioxidant activity) than compound II. The ability of compound I and II to reduce iron (III) to iron (II) ions were calculated as 929 and 11 µM FeSO4.7H2O equivalent/g sample, respectively.To summarize, the above-mentioned results indicate that compound II has inefficient antioxidant activity and Compound I has effective antioxidant activity.

References

  • [1] Liu. Z., Wang, B., Yang, Z., Li, Y., Qin, D., Li, T. 2009. “Synthesis, crystal structure, DNA interaction and antioxidant activities of two novel water-soluble Cu(2þ) complexes derivated from 2-oxo-quinoline-3- carbaldehyde Schiff-bases“, Eur J Med Chem. 44, 4477-4484.
  • [2] Hussain, H., Babic, G., Durst, T., Wright, J., Flueraru, M., Chichirau, A., Chepelev, L.L.2003. “Development of Novel Antioxidants:  Design, Synthesis, and Reactivity“, Org. Chem. 6, 7023-7032.
  • [3] Ünver, Y., Sancak, K., Çelik, F., Birinci, E., Küçük, M., Soylu, S., Burnaz, N. A. 2014. “New thiophene-1,2,4-triazole-5(3)-ones: highly bioactive thiosemicarbazides, structures of schiff bases and triazole-thiols“, European Journal of Medicinal Chemistry 84, 639-650.
  • [4] Ünver, Y., Deniz, S., Çelik, F., Akar, Z., Küçük, M., Sancak, K. 2016. “Synthesis of New 1,2,4-Triazole Compounds Containing Schiff and Mannich Bases (Morpholine) with Antioxidant and Antimicrobial Activities“, Journal of Enzym İnhibition and Medicinal Chemistry 31(3S), 89-95.
  • [5] Ünver, Y., Bektaş, E. 2018. “Synthesis and biological activity of new Schiff bases of benzylideneamine bearing thiophene, 1,2,4-triazolone, 1,3,4-oxadiazole, morpholine moieties“, Letters in Drug Design & Discovery 15, 706-712.
  • [6] Ünver, Y., Bektaş, E., Direkel, Ş. 2018. “Synthesis And Antioxidant And Antileishmanial Activities of New Bis N-Amino Triazole Derivatives“, Russian Journal of General Chemistry 88, 2616-2620.
  • [7] Ünver, Y., Tuluk, M., Kahriman, N., Emirik,E., Bektaş, E., Direkel, Ş. 2019. “New Chalcone Derivatives With Schiff Base-Thiophene: Synthesis, Biological Activity And Molecular Docking Studies“, Russian Journal of General Chemistry 89, 794-799.
  • [8] Ünver, Y., Baş, H., Bıyıklıoğlu, Z. 2019. “Non-peripherally 4-{[(1E)-1-benzothien-2-ylmethylene]amino} phenol substituted zinc(II), manganese(III), cobalt(II) phthalocyanines:Synthesis and electrochemistry“, Journal of Molecular Structure 1178, 508-513.
  • [9] Serbest, K., Özen, A., Ünver, Y., Er, M., Değirmencioğlu, İ., Sancak, K. 2009. “Spectroscopic and theoretical study of 1,2,4-triazole-3-one based salicyaldimine complexes and evaluation of superoxide-scavenging propertie“, Journal of Molecular Structure 922, 1-10.
  • [10] Serbest, K., Değirmencioğlu, İ., Ünver, Y., Er, M., Kantar, C., Sancak, K. 2007. “Microwave-assisted synthesis and characterization and theorical calculations of the first example of free and metalo phthalocyanines from salen type Schiff base derivative bearing thiophen and triazole heterocyclic ring“, Journal of Organometallic Chemistry 692, 5646-5654.
  • [11] Avramova, P., Danchev, N., Buyukliev, R., Bogoslovova, T. 1998. “Synthesis, Toxicological, and Pharmacological Assessment of Derivatives of 2-Aryl-4-(3-arylpropyl)morpholines“, Arch Pharm. 331:342–346.
  • [12] Dhahagani, K.; Mathan Kumar, S.; Chakkaravarthi, G.; Anitha, K.; Rajesh, J.; Ramu, A.; Rajagopal, G. 2014. “Synthesis and spectral characterization of Schiff base complexes of Cu(II), Co(II), Zn(II) and VO(IV) containing 4-(4-aminophenyl)morpholine derivatives: Antimicrobial evaluation and anticancer studies“.Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy 117, 87-94.
  • [13] Benzie I.F.F., Szeto, Y.T. 1999. “Total Antioxidant Capacity of Teas by the Ferric Reducing/Antioxidant Power Assay“, J. Agric. Food Chem. 47(2), 633–636.

Details

Primary Language English
Subjects Chemistry, Analytical
Journal Section Research Articles
Authors

Dilek ÜNLÜER> (Primary Author)
Karadeniz Technical University
0000-0003-1939-2246
Türkiye


Ersan BEKTAŞ This is me
Giresun University
0000-0001-9030-6908
Andorra


Yasemin ÜNVER>
Karadeniz Technical University
0000-0001-5834-3223
Andorra

Publication Date December 11, 2019
Application Date November 4, 2019
Acceptance Date November 18, 2019
Published in Issue Year 2019, Volume 1, Issue 1

Cite

Bibtex @research article { turkjac642361, journal = {Turkish Journal of Analytical Chemistry}, eissn = {2687-6698}, address = {Karadeniz Teknik Üniversitesi, Fen Fakültesi, Kimya Bölümü, Oda No: 111, 61080 Trabzon}, publisher = {Miraç OCAK}, year = {2019}, volume = {1}, number = {1}, pages = { - }, title = {Schiff base derivatives with morpholine and antioxidant activity}, key = {cite}, author = {Ünlüer, Dilek and Bektaş, Ersan and Ünver, Yasemin} }
APA Ünlüer, D. , Bektaş, E. & Ünver, Y. (2019). Schiff base derivatives with morpholine and antioxidant activity . Turkish Journal of Analytical Chemistry , 1 (1) , . Retrieved from https://dergipark.org.tr/en/pub/turkjac/issue/50574/642361
MLA Ünlüer, D. , Bektaş, E. , Ünver, Y. "Schiff base derivatives with morpholine and antioxidant activity" . Turkish Journal of Analytical Chemistry 1 (2019 ): <https://dergipark.org.tr/en/pub/turkjac/issue/50574/642361>
Chicago Ünlüer, D. , Bektaş, E. , Ünver, Y. "Schiff base derivatives with morpholine and antioxidant activity". Turkish Journal of Analytical Chemistry 1 (2019 ):
RIS TY - JOUR T1 - Schiff base derivatives with morpholine and antioxidant activity AU - DilekÜnlüer, ErsanBektaş, YaseminÜnver Y1 - 2019 PY - 2019 N1 - DO - T2 - Turkish Journal of Analytical Chemistry JF - Journal JO - JOR SP - EP - VL - 1 IS - 1 SN - -2687-6698 M3 - UR - Y2 - 2019 ER -
EndNote %0 Turkish Journal of Analytical Chemistry Schiff base derivatives with morpholine and antioxidant activity %A Dilek Ünlüer , Ersan Bektaş , Yasemin Ünver %T Schiff base derivatives with morpholine and antioxidant activity %D 2019 %J Turkish Journal of Analytical Chemistry %P -2687-6698 %V 1 %N 1 %R %U
ISNAD Ünlüer, Dilek , Bektaş, Ersan , Ünver, Yasemin . "Schiff base derivatives with morpholine and antioxidant activity". Turkish Journal of Analytical Chemistry 1 / 1 (December 2019): - .
AMA Ünlüer D. , Bektaş E. , Ünver Y. Schiff base derivatives with morpholine and antioxidant activity. TurkJAC. 2019; 1(1): -.
Vancouver Ünlüer D. , Bektaş E. , Ünver Y. Schiff base derivatives with morpholine and antioxidant activity. Turkish Journal of Analytical Chemistry. 2019; 1(1): -.
IEEE D. Ünlüer , E. Bektaş and Y. Ünver , "Schiff base derivatives with morpholine and antioxidant activity", Turkish Journal of Analytical Chemistry, vol. 1, no. 1, Dec. 2019