Research Article
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Implications of a twelve-week aerobic exercise on functional work capacity in HIV positive clients on antiretroviral therapy

Year 2024, Volume: 10 Issue: 3, 191 - 198, 30.09.2024
https://doi.org/10.31459/turkjkin.1526404

Abstract

The implications of aerobic exercise on functional work capacity of Human Immunodeficiency Virus (HIV) positive clients on antiretroviral therapy (ART) in Uganda have been established. ART and the efforts to scale it up have significantly improved the value of life and life’s hope of among PLHIV. Despite the presence of ART HIV disease is still seen in wards and a significant loss of life due to AIDS. This study provides useful information to the Ministry of Health of Uganda on the implications of aerobic exercises on functional work capacity as a clinical outcome to HIV positive clients in Uganda. This helps in refining the existing information on aerobic exercises and their relevancy in management of HIV positive clients. An experimental study was conducted among HIV positive clients who had been on treatment for at least 12 months prior to the study. Volunteers were randomly assigned to a control group (Group 1), where no treatment was administered, and an experimental group (Group 2), where a twelve-week moderate intensity aerobic exercise was administered. Assessment of functional work capacity was done as a pre-test and post-test for both groups. The results showed that aerobic exercises significantly improved both heart rate and VO2max with p-values of <0.001 indicating a significant improvement of VO2max from 25.13 to 34.19ml/kg/min while the control group improved by 3.73ml/kg/min. Aerobic exercise can, therefore, improve the quality of life; reduce the cost of management, mobility and mortality rates in HIV positive clients on ART in Uganda.

Ethical Statement

The Study was approved by: Lacor Hospital Institutional Research and Ethical Committee (RHIREC) No 0183/07/2020 and it was carried out in accordance with the Code of Ethics of the World Medical Association also known as a declaration of Helsinki. And thereafter approved by Uganda National Council for Science and Technology Ref: HS 1276ES

Supporting Institution

Kyambogo University Uganda and Uganda Peoples Defence Forces

Thanks

I thank you for the support you gave me in my previous article I have mobilized colleagues to use this journal and that is what inspired me to submit another article. Thank you

References

  • Bopp, C., Phillips, K. D., Fulk, L. J., & Hand, G. A. (2003). Clinical implications of therapeutic exercise in HIV/AIDS. J Assoc Nurses AIDS Care, 14(1), 73-78.
  • Brooks, C. (2017). The effect of a CPET familiarization session on aerobic capacity (VO2max) in sedentary middle-aged females Master's thesis. University of North Carolina.
  • Burnley, M., & Jones, A. M. (2007). Oxygen uptake kinetics as a determinant of sports performance. European Journal of Sport Science, 7(2), 63-79.
  • CDC, (Center for Disease Control and Prevention, 2022). Perceived exertion (Borg rating of perceived exertion scale). Retrieved June 28, 2024, from https://www.cdc.gov/physicalactivity/basics/measuring/exertion.htm
  • Jaggers, J. R., Hand, G. A., Dudgeon, W. D., Burgess, S., Phillips, K. D., Durstine, J. L., & Blair, S. N. (2014). Aerobic and resistance training improves mood state among adults living with HIV. Int J Sports Med, 36(2), 175-181.
  • Kalatzi, P., Dinas, P. C., Chryssanthopoulos, C., Karatzanos, E., Nanas, S., & Philippou, A. (2022). Impact of supervised aerobic exercise on clinical physiological and mental parameters of people living with HIV: a systematic review and meta-analyses of randomized controlled trials. HIV Res Clin Pract, 23(1), 107-119.
  • Keyser, R. E., Peralta, L., Cade, W. T., Miller, S., & Anixt, J. (2000). Functional aerobic impairment in adolescents seropositive for HIV: a quasiexperimental analysis. Arch Phys Med Rehabil, 81(11), 1479-1484.
  • Lea, J. W., O’Driscoll, J. M., Hulbert, S., Scales, J., & Wiles, J. D. (2022). Convergent validity of ratings of perceived exertion during resistance exercise in healthy participants: a systematic review and meta-analysis. Sports Medicine Open, 8(1), 2.
  • Maciejczyk, M., Więcek, M., Szymura, J., Szyguła, Z., Wiecha, S., & Cempla, J. (2014). The influence of increased body fat or lean body mass on aerobic performance. PloS One, 9(4), e95797.
  • Mangona, L., Daca, T., Tchonga, F., Bule, O., Bhatt, N., Jani, I., ... & Prista, A. (2015). Suppl 1: M5: effect of different types of exercise in HIV+ Mozambican women using antiretroviral therapy. Open AIDS J, 9, 89-95.
  • Nystoriak, M. A., & Bhatnagar, A. (2018). Cardiovascular effects and benefits of exercise. Front Cardiovasc Med, 5, 135.
  • O'Brien, K., Tynan, A. M., Nixon, S., & Glazier, R. H. (2008). Effects of progressive resistive exercise in adults living with HIV/AIDS: systematic review and meta-analysis of randomized trials. AIDS Care, 20(6), 631-653.
  • O’Brien, K. K., Tynan, A. M., Nixon, S. A., & Glazier, R. H. (2016). Effectiveness of aerobic exercise for adults living with HIV: systematic review and meta-analysis using the Cochrane Collaboration protocol. BMC Infect Dis, 16, 182.
  • Olatunbosun, T. O., Awotidebe, T. O., Adedoyin, R. A., Fasakin, O. M., & Ogunyemi, S. A. (2021). Correlation between self-reported daily activity and submaximal walk test in the assessment of functional capacity among patients with hypertension. Int J Clin Cardiol, 8, 238.
  • Penedo, F. J., & Dahn, J. R. (2005). Exercise and well-being: a review of mental and physical health benefits associated with physical activity. Curr Opin Psychiatry, 18(2), 189-193.
  • Ravani, P., Kilb, B., Bedi, H., Groeneveld, S., Yilmaz, S., Mustata, S., & Alberta Kidney Disease Network. (2012). The Duke Activity Status Index in patients with chronic kidney disease: a reliability study. Clinical Journal of the American Society of Nephrology, 7(4), 573-580.
  • Riedel, B., Li, M. H., Lee, C. A., Ismail, H., Cuthbertson, B. H., Wijeysundera, D. N., ... & Edwards, M. (2021). A simplified (modified) Duke Activity Status Index (M-DASI) to characterise functional capacity: a secondary analysis of the Measurement of Exercise Tolerance before Surgery (METS) study. Br J Anaesth, 126(1), 181-190.
  • Scribbans, T. D., Vecsey, S., Hankinson, P. B., Foster, W. S., & Gurd, B. J. (2016). The effect of training intensity on VO2max in young healthy adults: a meta-regression and meta-analysis. Int J Exerc Sci, 9(2), 230.
  • Simtowe, F., & Kinkingninhoun-Medagbe, F. M. (2011). The impact of HIV/AIDS on labor markets, productivity and welfare in Southern Africa: A critical review and analysis. Afr J Agric Res, 6(10), 2118-2131.
  • Stanley, M. M., Wadzani, G., Adamu, B., Amina, K., Oyeyemi, A. Y., Umeonwuka, C. I., & Akanbi OA. (2017). Aerobic exercise improves quality of life and CD4 cell counts in HIV seropositives in Nigeria. J Hum Virol Retrovirol, 5(3), 00151.
  • Vajpayee, M., & Mohan, T. (2011). Current practices in laboratory monitoring of HIV infection. Indian J Med Res, 134(6), 801-822.
  • Warburton, D. E., Nicol, C. W., & Bredin, S. S. (2006). Health benefits of physical activity: the evidence. CMAJ, 174(6), 801-809.
  • Webel, A. R., Jenkins, T., Longenecker, C. T., Vest, M., Davey, C. H., Currie, J., ... & Josephson, R. A. (2019). Relationship of HIV status and fatigue, cardiorespiratory fitness, myokines and physical activity. J Assoc Nurses AIDS Care, 30(4), 392–404.
  • West, N. S. (2021). Mental health among people living with HIV and impacts on the HIV care continuum: a focus on Rakai, Uganda Doctoral dissertation. Johns Hopkins University.
  • Yebra, G., Ragonnet-Cronin, M., Ssemwanga, D., Parry, C. M., Logue, C. H., Cane, P. A., ... & Brown, A. J. L. (2015). Analysis of the history and spread of HIV-1 in Uganda using phylodynamics. J Gen Virol, 96(Pt 7), 1890-1898.
  • Zheng, J., Pan, T., Jiang, Y., & Shen, Y. (2022). Effects of Short‐and Long‐Term Detraining on Maximal Oxygen Uptake in Athletes: A Systematic Review and Meta‐Analysis. Biomed Res Int, 2022, 2130993.
  • Zinoubi, B., Zbidi, S., Vandewalle, H., Chamari, K., & Driss, T. (2018). Relationships between RPE, heart rate and blood lactate during continuous and alternated-intensity cycling exercises. Biol Sport, 35(1), 29-37.
Year 2024, Volume: 10 Issue: 3, 191 - 198, 30.09.2024
https://doi.org/10.31459/turkjkin.1526404

Abstract

References

  • Bopp, C., Phillips, K. D., Fulk, L. J., & Hand, G. A. (2003). Clinical implications of therapeutic exercise in HIV/AIDS. J Assoc Nurses AIDS Care, 14(1), 73-78.
  • Brooks, C. (2017). The effect of a CPET familiarization session on aerobic capacity (VO2max) in sedentary middle-aged females Master's thesis. University of North Carolina.
  • Burnley, M., & Jones, A. M. (2007). Oxygen uptake kinetics as a determinant of sports performance. European Journal of Sport Science, 7(2), 63-79.
  • CDC, (Center for Disease Control and Prevention, 2022). Perceived exertion (Borg rating of perceived exertion scale). Retrieved June 28, 2024, from https://www.cdc.gov/physicalactivity/basics/measuring/exertion.htm
  • Jaggers, J. R., Hand, G. A., Dudgeon, W. D., Burgess, S., Phillips, K. D., Durstine, J. L., & Blair, S. N. (2014). Aerobic and resistance training improves mood state among adults living with HIV. Int J Sports Med, 36(2), 175-181.
  • Kalatzi, P., Dinas, P. C., Chryssanthopoulos, C., Karatzanos, E., Nanas, S., & Philippou, A. (2022). Impact of supervised aerobic exercise on clinical physiological and mental parameters of people living with HIV: a systematic review and meta-analyses of randomized controlled trials. HIV Res Clin Pract, 23(1), 107-119.
  • Keyser, R. E., Peralta, L., Cade, W. T., Miller, S., & Anixt, J. (2000). Functional aerobic impairment in adolescents seropositive for HIV: a quasiexperimental analysis. Arch Phys Med Rehabil, 81(11), 1479-1484.
  • Lea, J. W., O’Driscoll, J. M., Hulbert, S., Scales, J., & Wiles, J. D. (2022). Convergent validity of ratings of perceived exertion during resistance exercise in healthy participants: a systematic review and meta-analysis. Sports Medicine Open, 8(1), 2.
  • Maciejczyk, M., Więcek, M., Szymura, J., Szyguła, Z., Wiecha, S., & Cempla, J. (2014). The influence of increased body fat or lean body mass on aerobic performance. PloS One, 9(4), e95797.
  • Mangona, L., Daca, T., Tchonga, F., Bule, O., Bhatt, N., Jani, I., ... & Prista, A. (2015). Suppl 1: M5: effect of different types of exercise in HIV+ Mozambican women using antiretroviral therapy. Open AIDS J, 9, 89-95.
  • Nystoriak, M. A., & Bhatnagar, A. (2018). Cardiovascular effects and benefits of exercise. Front Cardiovasc Med, 5, 135.
  • O'Brien, K., Tynan, A. M., Nixon, S., & Glazier, R. H. (2008). Effects of progressive resistive exercise in adults living with HIV/AIDS: systematic review and meta-analysis of randomized trials. AIDS Care, 20(6), 631-653.
  • O’Brien, K. K., Tynan, A. M., Nixon, S. A., & Glazier, R. H. (2016). Effectiveness of aerobic exercise for adults living with HIV: systematic review and meta-analysis using the Cochrane Collaboration protocol. BMC Infect Dis, 16, 182.
  • Olatunbosun, T. O., Awotidebe, T. O., Adedoyin, R. A., Fasakin, O. M., & Ogunyemi, S. A. (2021). Correlation between self-reported daily activity and submaximal walk test in the assessment of functional capacity among patients with hypertension. Int J Clin Cardiol, 8, 238.
  • Penedo, F. J., & Dahn, J. R. (2005). Exercise and well-being: a review of mental and physical health benefits associated with physical activity. Curr Opin Psychiatry, 18(2), 189-193.
  • Ravani, P., Kilb, B., Bedi, H., Groeneveld, S., Yilmaz, S., Mustata, S., & Alberta Kidney Disease Network. (2012). The Duke Activity Status Index in patients with chronic kidney disease: a reliability study. Clinical Journal of the American Society of Nephrology, 7(4), 573-580.
  • Riedel, B., Li, M. H., Lee, C. A., Ismail, H., Cuthbertson, B. H., Wijeysundera, D. N., ... & Edwards, M. (2021). A simplified (modified) Duke Activity Status Index (M-DASI) to characterise functional capacity: a secondary analysis of the Measurement of Exercise Tolerance before Surgery (METS) study. Br J Anaesth, 126(1), 181-190.
  • Scribbans, T. D., Vecsey, S., Hankinson, P. B., Foster, W. S., & Gurd, B. J. (2016). The effect of training intensity on VO2max in young healthy adults: a meta-regression and meta-analysis. Int J Exerc Sci, 9(2), 230.
  • Simtowe, F., & Kinkingninhoun-Medagbe, F. M. (2011). The impact of HIV/AIDS on labor markets, productivity and welfare in Southern Africa: A critical review and analysis. Afr J Agric Res, 6(10), 2118-2131.
  • Stanley, M. M., Wadzani, G., Adamu, B., Amina, K., Oyeyemi, A. Y., Umeonwuka, C. I., & Akanbi OA. (2017). Aerobic exercise improves quality of life and CD4 cell counts in HIV seropositives in Nigeria. J Hum Virol Retrovirol, 5(3), 00151.
  • Vajpayee, M., & Mohan, T. (2011). Current practices in laboratory monitoring of HIV infection. Indian J Med Res, 134(6), 801-822.
  • Warburton, D. E., Nicol, C. W., & Bredin, S. S. (2006). Health benefits of physical activity: the evidence. CMAJ, 174(6), 801-809.
  • Webel, A. R., Jenkins, T., Longenecker, C. T., Vest, M., Davey, C. H., Currie, J., ... & Josephson, R. A. (2019). Relationship of HIV status and fatigue, cardiorespiratory fitness, myokines and physical activity. J Assoc Nurses AIDS Care, 30(4), 392–404.
  • West, N. S. (2021). Mental health among people living with HIV and impacts on the HIV care continuum: a focus on Rakai, Uganda Doctoral dissertation. Johns Hopkins University.
  • Yebra, G., Ragonnet-Cronin, M., Ssemwanga, D., Parry, C. M., Logue, C. H., Cane, P. A., ... & Brown, A. J. L. (2015). Analysis of the history and spread of HIV-1 in Uganda using phylodynamics. J Gen Virol, 96(Pt 7), 1890-1898.
  • Zheng, J., Pan, T., Jiang, Y., & Shen, Y. (2022). Effects of Short‐and Long‐Term Detraining on Maximal Oxygen Uptake in Athletes: A Systematic Review and Meta‐Analysis. Biomed Res Int, 2022, 2130993.
  • Zinoubi, B., Zbidi, S., Vandewalle, H., Chamari, K., & Driss, T. (2018). Relationships between RPE, heart rate and blood lactate during continuous and alternated-intensity cycling exercises. Biol Sport, 35(1), 29-37.
There are 27 citations in total.

Details

Primary Language English
Subjects Exercise Physiology
Journal Section Original Research Articles
Authors

Mwebaze Nicholas 0009-0002-5893-2428

Constance A.n. Nsibambi This is me 0009-0006-6036-9856

Edward Ojuka This is me 0009-0008-5105-1103

Mshilla Maghanga This is me 0009-0009-4143-1505

Publication Date September 30, 2024
Submission Date August 1, 2024
Acceptance Date September 24, 2024
Published in Issue Year 2024 Volume: 10 Issue: 3

Cite

APA Nicholas, M., Nsibambi, C. A., Ojuka, E., Maghanga, M. (2024). Implications of a twelve-week aerobic exercise on functional work capacity in HIV positive clients on antiretroviral therapy. Turkish Journal of Kinesiology, 10(3), 191-198. https://doi.org/10.31459/turkjkin.1526404

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