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Yara İyileşmesinde Epidermal Büyüme Faktörü (EGF) İçeren Yara Örtüsü (Neoderm®) Etkisi

Year 2015, Volume: 23 Issue: 2, 63 - 66, 01.08.2015

Abstract

Yara iyileşmesinde etkili olan tanımlanmış büyüme faktörleri mevcuttur. Bu faktörlerden Epidermal Büyüme Faktör’ün (EGF) topikal olarak uygulamasının yara iyileşmesi üzerine etkilerinin incelendiği araştırmalarda EGF’nin epitelizasyonu uyardığı, yara iyileşmesinin erken safhalarında dermis oluşumu üzerine etkili olduğu ve kronik yaraların iyileşmesini uyardığı bildirilmiştir. 2010-2012 yılları arasında abdominoplasti yapılması isteğiyle başvuran hastalardan rastgele seçilen 10 kadın hasta çalışmaya alındı. Tüm hastaların insizyonlarının sağ tarafı Thiocilline® antibiyotikli deri pomadıyla (basitrasin 15000 UI / neomisin sülfat 150 mg, Abdi İbrahim), sol tarafı serum fizyolojikle ıslatılmış Neoderm® yara örtüsüyle kapatıldı. Hastalar, ameliyat sonrası 4. günde karşı tarafa kıyasla sol tarafta ağrıda azalma tanımladı (p≤0.05) ancak yara görünümünde bir fark görülmedi. Ameliyat sonrası 8. günde hastaların sol taraf yara dudaklarındaki hiperemide karşı tarafla karşılaştırıldığında belirgin azalma görüldü (p≤0.05). Sol tarafta inflamasyon fazının çok hızlı geçtiği düşünüldü. Sol taraftaki yara iyileşmesindeki hızlanma etkisi 30. günde devam etse de hastaların 2. ay ve daha sonraki kontrollerinde sağ ve sol taraf arasında fizik muayenede belirgin fark gözlenmedi. Ameliyat sonrası birinci yılda yara maturasyonunun geliştiği görülürken skar görünümü açısından bir fark yoktu. Neoderm® yara örtüsü içinde bulunan EGF nedeniyle yara iyileşmesini hızlandırmakta, ağrıyı azaltmaktadır. Yara iyileşmesinde hızlanma istenen akut ve kronik yaralarda kullanılabilir.

References

  • Thorne CH. Techniques and principles in Plastic Surgery. In: 1.
  • Thorne CH. Grabb&Smith’s Plastic Surgery. (ed). 6th ed. Philadel
  • phia: Lippincolt Williams&Wilkins, 2007: 3-15.
  • Nanney LB. Epidermal and dermal effects of epidermal 2.
  • growth factor during wound repair. J Invest Dermatol. 1990;94(5):624-9.
  • Cohen S. Isolation of a mouse submaxillary gland protein ac- 3.
  • celerating incisor eruption and eyelid opening in the new-born
  • animal. J Biol Chem. 1962;237(5):1555-62.
  • Turker M, Erbas D, Yilmaz D. SMG ekstresinin submandibular bez 4.
  • ve kan prostaglandin seviyelerine etkileri. GÜ Tıp Fak. Dergisi. 1989;5(1):109-15.
  • Cohen S, Taylor JM. Epidermal Growth Factor: chemical and 5.
  • biological characterization. Recent Prog Horm Res. 1974;30:533- 50.
  • Pratt RM. Role of epidermal growth factor in embryonic devel- 6.
  • opment. Curr Top Dev Biol. 1987;22:175-93.
  • Degim Z, Celebi N, Alemdaroglu C, Deveci M, Ozturk S, Ozo- 7.
  • gul C. Evaluation of chitosan gel containing liposome-loaded
  • epidermal growth factor on burn wound healing. Int Wound J. 2011;8(4):343-54.
  • Laato M, Heino J, Kahari VM, Niinikoski J, Gerdin B. Epidermal 8.
  • growth factor (EGF) prevents methylprednisolone-induced in
  • hibition of wound healing. J Surg Res. 1989;17:354-9.
  • Tiaka EK, Papanas N, Manolakis AC, Georgiadis GS. Epidermal 9.
  • growth factor in the treatment of diabetic foot ulcers: an up
  • date. Perspect Vasc Surg Endovasc Ther. 2012;24(1):37-44. 10. Oka Y, Orth DN. Human plasma epidermal growth factor/beta
  • urogastrone is associated with blood platelets. J Clin Invest.
  • ;72:249-59. 11. Brown GL, Nanney LB, Griffen J, Cramer AB, Yancey JM, Curt
  • singer LJ 3rd, et al. Enhancement of wound healing by topi
  • cal treatment with epidermal growth factor. N Engl J Med.
  • ;321(2):76-9. 12. Celebi N, Erden N, Gonul B, Koz M. Effects of epidermal growth
  • factor dosage forms on dermal wound strength in mice. J Pharm
  • Pharmacol. 1994;46(5):386-7. 13. Gonul B, Soylemezoglu T, Babul A, Celebi N. Effects of epidermal
  • growth factor dosage forms on mice full-thickness skin wound
  • zinc levels and relation to wound strength. J Pharm Pharmacol.
  • ;50(6):641-4. 14. Falanga V, Eaglstein WH, Bucalo B, Katz MH, Harris B, Carson P.
  • Topical use of human recombinant epidermal growth factor (h
  • EGF) in venous ulcers. J Dermatol Surg Oncol. 1992;18(7):604-6. 15. Rudkin GH, Miller TA. Growth factors in surgery. Plast Reconstr
  • Surg. 1996;97(2):469-76. 16. Baskin LS, Sutherland RS, Thomson AA, Nguyen HT, Morgan DM,
  • Hayward SW, et al. Growth factors in bladder wound healing. J
  • Urol. 1997;157:2388-95. 17. Demling RH, L. DeSanti / Burns Management of partial thick
  • ness facial burns (comparison of topical antibiotics and bio
  • engineered skin substitutes) 1999;25: 256-261 18. Hinman C, Maibach H. E€ect of exposure and occlusion on ex
  • perimental human skin wounds. Nature 1963;200:377-8. 19. Alverez O, Mertz P, Eaglstein RW. The e€ect of occlusive dres
  • sings on collagen synthesis and epithelialization in super®cial
  • wounds. J. Surg.Res. 1983;35:142-8.

The Effect of Epidermal Growth Factor (EGF) Containing Wound Dressing (Neoderm ®) on Wound Healing

Year 2015, Volume: 23 Issue: 2, 63 - 66, 01.08.2015

Abstract

Growth factors effective on wound healing are identified. In studies investigating the effects of topical application of Epidermal Growth Factor (EGF) upon wound healing, which is one of these factors, it is reported that EGF stimulates wound healing, is effective on dermis formation in the early stages of wound healing, and stimulates healing of chronic wounds. 10 female subjects randomly selected among patients applying for abdominoplasty between the years 2010-2012 were enrolled in the study. In all patients, the right side of the incision was covered with a dressing containing Thiocilline® skin pomade (Bacitracin 15000 IU / Neomycin sulfate 150 mg, Abdi İbrahim) and left side was covered with saline soaked Neoderm ® wound dress. Patients reported a reduction in the pain on the left side when compared to the opposite side on the 4th day after surgery (p≤0.05) although there was no difference in the appearance of the wound. There was a significant reduction of the hyperemia in the left side of the wound when compared to the other side (p≤0.05) on the 8th day after surgery. It was thought that the inflammation phase subsided very quickly on the left side. Although the acceleration effect on the wound healing continued on the 30th day, no significant difference was observed in the physical examination between the left and right sides in the second month and subsequent controls of the patients. In the first year after surgery, it was observed that wound maturation was accomplished and there was no difference in terms of the appearance of the scar. Neoderm® wound dressing accelerates wound healing and reduces pain by virtue of the EGF content. It can be used an in acute and chronic wounds when acceleration in wound healing is desired.

References

  • Thorne CH. Techniques and principles in Plastic Surgery. In: 1.
  • Thorne CH. Grabb&Smith’s Plastic Surgery. (ed). 6th ed. Philadel
  • phia: Lippincolt Williams&Wilkins, 2007: 3-15.
  • Nanney LB. Epidermal and dermal effects of epidermal 2.
  • growth factor during wound repair. J Invest Dermatol. 1990;94(5):624-9.
  • Cohen S. Isolation of a mouse submaxillary gland protein ac- 3.
  • celerating incisor eruption and eyelid opening in the new-born
  • animal. J Biol Chem. 1962;237(5):1555-62.
  • Turker M, Erbas D, Yilmaz D. SMG ekstresinin submandibular bez 4.
  • ve kan prostaglandin seviyelerine etkileri. GÜ Tıp Fak. Dergisi. 1989;5(1):109-15.
  • Cohen S, Taylor JM. Epidermal Growth Factor: chemical and 5.
  • biological characterization. Recent Prog Horm Res. 1974;30:533- 50.
  • Pratt RM. Role of epidermal growth factor in embryonic devel- 6.
  • opment. Curr Top Dev Biol. 1987;22:175-93.
  • Degim Z, Celebi N, Alemdaroglu C, Deveci M, Ozturk S, Ozo- 7.
  • gul C. Evaluation of chitosan gel containing liposome-loaded
  • epidermal growth factor on burn wound healing. Int Wound J. 2011;8(4):343-54.
  • Laato M, Heino J, Kahari VM, Niinikoski J, Gerdin B. Epidermal 8.
  • growth factor (EGF) prevents methylprednisolone-induced in
  • hibition of wound healing. J Surg Res. 1989;17:354-9.
  • Tiaka EK, Papanas N, Manolakis AC, Georgiadis GS. Epidermal 9.
  • growth factor in the treatment of diabetic foot ulcers: an up
  • date. Perspect Vasc Surg Endovasc Ther. 2012;24(1):37-44. 10. Oka Y, Orth DN. Human plasma epidermal growth factor/beta
  • urogastrone is associated with blood platelets. J Clin Invest.
  • ;72:249-59. 11. Brown GL, Nanney LB, Griffen J, Cramer AB, Yancey JM, Curt
  • singer LJ 3rd, et al. Enhancement of wound healing by topi
  • cal treatment with epidermal growth factor. N Engl J Med.
  • ;321(2):76-9. 12. Celebi N, Erden N, Gonul B, Koz M. Effects of epidermal growth
  • factor dosage forms on dermal wound strength in mice. J Pharm
  • Pharmacol. 1994;46(5):386-7. 13. Gonul B, Soylemezoglu T, Babul A, Celebi N. Effects of epidermal
  • growth factor dosage forms on mice full-thickness skin wound
  • zinc levels and relation to wound strength. J Pharm Pharmacol.
  • ;50(6):641-4. 14. Falanga V, Eaglstein WH, Bucalo B, Katz MH, Harris B, Carson P.
  • Topical use of human recombinant epidermal growth factor (h
  • EGF) in venous ulcers. J Dermatol Surg Oncol. 1992;18(7):604-6. 15. Rudkin GH, Miller TA. Growth factors in surgery. Plast Reconstr
  • Surg. 1996;97(2):469-76. 16. Baskin LS, Sutherland RS, Thomson AA, Nguyen HT, Morgan DM,
  • Hayward SW, et al. Growth factors in bladder wound healing. J
  • Urol. 1997;157:2388-95. 17. Demling RH, L. DeSanti / Burns Management of partial thick
  • ness facial burns (comparison of topical antibiotics and bio
  • engineered skin substitutes) 1999;25: 256-261 18. Hinman C, Maibach H. E€ect of exposure and occlusion on ex
  • perimental human skin wounds. Nature 1963;200:377-8. 19. Alverez O, Mertz P, Eaglstein RW. The e€ect of occlusive dres
  • sings on collagen synthesis and epithelialization in super®cial
  • wounds. J. Surg.Res. 1983;35:142-8.
There are 43 citations in total.

Details

Other ID JA59BF36ZV
Journal Section Articles
Authors

Bilsev İnce This is me

Mehmet Dadacı This is me

Fatma Bilgen This is me

Zeynep Altuntaş This is me

Publication Date August 1, 2015
Published in Issue Year 2015 Volume: 23 Issue: 2

Cite

APA İnce, B., Dadacı, M., Bilgen, F., Altuntaş, Z. (2015). Yara İyileşmesinde Epidermal Büyüme Faktörü (EGF) İçeren Yara Örtüsü (Neoderm®) Etkisi. Türk Plastik Rekonstrüktif Ve Estetik Cerrahi Dergisi, 23(2), 63-66.
AMA İnce B, Dadacı M, Bilgen F, Altuntaş Z. Yara İyileşmesinde Epidermal Büyüme Faktörü (EGF) İçeren Yara Örtüsü (Neoderm®) Etkisi. turkplastsurg. August 2015;23(2):63-66.
Chicago İnce, Bilsev, Mehmet Dadacı, Fatma Bilgen, and Zeynep Altuntaş. “Yara İyileşmesinde Epidermal Büyüme Faktörü (EGF) İçeren Yara Örtüsü (Neoderm®) Etkisi”. Türk Plastik Rekonstrüktif Ve Estetik Cerrahi Dergisi 23, no. 2 (August 2015): 63-66.
EndNote İnce B, Dadacı M, Bilgen F, Altuntaş Z (August 1, 2015) Yara İyileşmesinde Epidermal Büyüme Faktörü (EGF) İçeren Yara Örtüsü (Neoderm®) Etkisi. Türk Plastik Rekonstrüktif Ve Estetik Cerrahi Dergisi 23 2 63–66.
IEEE B. İnce, M. Dadacı, F. Bilgen, and Z. Altuntaş, “Yara İyileşmesinde Epidermal Büyüme Faktörü (EGF) İçeren Yara Örtüsü (Neoderm®) Etkisi”, turkplastsurg, vol. 23, no. 2, pp. 63–66, 2015.
ISNAD İnce, Bilsev et al. “Yara İyileşmesinde Epidermal Büyüme Faktörü (EGF) İçeren Yara Örtüsü (Neoderm®) Etkisi”. Türk Plastik Rekonstrüktif Ve Estetik Cerrahi Dergisi 23/2 (August 2015), 63-66.
JAMA İnce B, Dadacı M, Bilgen F, Altuntaş Z. Yara İyileşmesinde Epidermal Büyüme Faktörü (EGF) İçeren Yara Örtüsü (Neoderm®) Etkisi. turkplastsurg. 2015;23:63–66.
MLA İnce, Bilsev et al. “Yara İyileşmesinde Epidermal Büyüme Faktörü (EGF) İçeren Yara Örtüsü (Neoderm®) Etkisi”. Türk Plastik Rekonstrüktif Ve Estetik Cerrahi Dergisi, vol. 23, no. 2, 2015, pp. 63-66.
Vancouver İnce B, Dadacı M, Bilgen F, Altuntaş Z. Yara İyileşmesinde Epidermal Büyüme Faktörü (EGF) İçeren Yara Örtüsü (Neoderm®) Etkisi. turkplastsurg. 2015;23(2):63-6.