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Arı sütünün obezite üzerine etkileri

Year 2022, , 87 - 95, 19.05.2022
https://doi.org/10.31467/uluaricilik.1058101

Abstract

Obezite insanların yaşam kalitesini etkileyen ve bazı ölümcül hastalıklar için risk faktörü oluşturan bir hastalıktır. Dünyada prevalansı artmaktadır ve en büyük etken beslenme sorunları ve hareketsiz yaşam tarzıdır. Önlenebilir bir hastalık olan obezite için doğal bir ürün, arı sütü (RJ) çeşitli çalışmalara konu olmuştur. Genç bal arıları (işçi arılar) tarafından salgılanan RJ kraliçe arının tek besin kaynağı ve olgunlaşmamış arıların ilk üç günlük besinleridir. RJ’nin antioksidan, antikanserojen, antimikrobiyal, antienflamatuar ve antiobezite aktiviteleri çeşitli çalışmalarla gösterilmiştir. Bu çalışma RJ’nin obezite ve beraberinde getirdiği sorunlar üzerindeki etkilerini konu alan çalışmaların bir derlemesidir.

References

  • Ali, A. M., & Kunugi, H. (2020). Apitherapy for Age-Related Skeletal Muscle Dysfunction (Sarcopenia): A Review on the Effects of Royal Jelly, Propolis, and Bee Pollen. Foods, 9(10). doi:10.3390/foods9101362.
  • Alvehus, M., Burén, J., Sjöström, M., Goedecke, J., & Olsson, T. The human visceral fat depot has a unique inflammatory profile. Obesity (Silver Spring), 18(5), 879-883. doi:10.1038/oby.2010.22.
  • Barker, S. A., Foster, A. B., Lamb, D. C., & Hodgson, N. (1959). Identification of 10-hydroxy-delta 2-decenoic acid in royal jelly. Nature, 183(4666), 996-997. doi:10.1038/183996a0.
  • Chen, Y. F., You, M. M., Liu, Y. C., Shi, Y. Z., Wang, K., Lu, Y. Y., & Hu, F. L. (2018). Potential protective effect of Trans-10-hydroxy-2-decenoic acid on the inflammation induced by Lipoteichoic acid. J. Funct. Foods, 45, 491-498.
  • Crane, E. (1990). Bees and Beekeeping, Practice and World Resources. Oxford, London: Heinemann Professional Publishing Ltd.
  • Dixit, P. K., & Patel, N. G. (1964). Insulin-Like Activity in Larval Foods of the Honeybee. Nature, 202, 189-190. doi:10.1038/202189a0.
  • Fratini, F., Cilia, G., Mancini, S., & Felicioli, A. (2016). Royal Jelly: An ancient remedy with remarkable antibacterial properties. Microbiol Res, 192, 130-141. doi:10.1016/j.micres.2016.06.007.
  • Irandoost, P., Mesri Alamdari, N., Saidpour, A., Shidfar, F., Farsi, F., Asghari Jafarabadi, M., Vafa, M. (2020). The effect of royal jelly and tocotrienol-rich fraction along with calorie restriction on hypothalamic endoplasmic reticulum stress and adipose tissue inflammation in diet-induced obese rats. BMC Res Notes, 13(1), 409. doi:10.1186/s13104-020-05258-0.
  • Irandoost, P., Mesri Alamdari, N., Saidpour, A., Shidfar, F., Roshanravan, N., Asghari Jafarabadi, M., Vafa, M. (2020). The effects of royal jelly and tocotrienol-rich fraction on impaired glycemic control and inflammation through irisin in obese rats. J Food Biochem, 44(12), e13493. doi:10.1111/jfbc.13493.
  • Isidorov, V. A., Bakier, S., & Grzech, I. (2012). Gas chromatographic-mass spectrometric investigation of volatile and extractable compounds of crude royal jelly. J Chromatogr B Analyt Technol Biomed Life Sci, 885-886, 109-116. doi:10.1016/j.jchromb.2011.12.025.
  • Kamakura, M. (2011). Royalactin induces queen differentiation in honeybees. Nature, 473(7348), 478-483. doi:10.1038/nature10093.
  • Kanelis, D., Tananaki, C., Liolios, V., Rodopoulou, M. A., Goras, G., Argena, N., & Thrasyvoulou, A. (2018). Investigating the Effect of Supplementary Feeding on Carbohydrate Composition and Quantity of Royal Jelly. Open Journal of Applied Sciences, 8, 141-149. doi:10.4236/ojapps.2018.84011.
  • Knekt, P., Kumpulainen, J., Jarvinen, R., Rissanen, H., Heliovaara, M., Reunanen, A., Aromaa, A. (2002). Flavonoid intake and risk of chronic diseases. The American Journal of Clinical Nutrition, 76, 560-568.
  • Kramer, K. J., Tager, H. S., Childs, C. N., & Speirs, R. D. (1977). Insulin-like hypoglycemic and immunological activities in honeybee royal jelly. J Insect Physiol, 23(2), 293-295. doi:10.1016/0022-1910(77)90044-0.
  • Kunugi, H., & Mohammed Ali, A. (2019). Royal Jelly and Its Components Promote Healthy Aging and Longevity: From Animal Models to Humans. Int J Mol Sci, 20(19). doi:10.3390/ijms20194662.
  • Li, K., Liu, C., Wahlqvist, M. L., & Li, D. (2020). Econutrition, brown and beige fat tissue and obesity. Asia Pacific Journal of Clinical Nutrition, 29(4), 668-680. doi:10.6133/apjcn.202012_29(4).0001.
  • Lin, C.-M., Chen, C.-T., Lee, H.-H., & Lin, J.-K. (2002). Prevention of cellular ROS damage by isovitexin and related flavonoids. Planta medica, 68(04), 365-367.
  • Manach, C., Scalbert, A., Morand, C., Remesy, C., & Jimenez, L. (2004). Polyphenols: Food sources and bioavailability. The American Journal of Clinical Nutrition, 79, 727-747. doi:10.1093/ajcn/79.5.727.
  • Mesri Alamdari, N., Irandoost, P., Roshanravan, N., Vafa, M., Jafarabadi, M. A., Alipour, S., Shidfar, F. (2020). Effects of Royal Jelly and Tocotrienol Rich Fraction in obesity treatment of calorie-restricted obese rats: a focus on white fat browning properties and thermogenic capacity. Nutr Metab (Lond), 17, 42. doi:https://doi.org/10.1186/s12986-020-00458-8.
  • Metwally Ibrahim, S. E. L., & Kosba, A. A. (2018). Royal jelly supplementation reduces skeletal muscle lipotoxicity and insulin resistance in aged obese rats. Pathophysiology, 25(4), 307-315. doi:10.1016/j.pathophys.2018.05.001.
  • Mihajlovic, D., Rajkovic, I., Chinou, I., & Colic, M. (2013). Dose-dependent immunomodulatory effects of 10-hydroxy-2-decenoic acid on human monocyte-derived dendritic cells. J. Funct. Foods, 5, 838-846.
  • Moutsatsou, P., Papoutsi, Z., Kassi, E., Heldring, N., Zhao, C., Tsiapara, A., Dahlman-Wright, K. (2010). Fatty acids derived from royal jelly are modulators of estrogen receptor functions. PLoS One, 5(12), e15594. doi:10.1371/journal.pone.0015594.
  • Pandey, K. B., & Rizvi, S. I. (2009). Plant polyphenols as dietary antioxidants in human health and disease. Oxidative Medicine and Cellular Longevity, 2, 270-278. doi:10.4161/oxim.2.5.9498.
  • Pandeya, P. R., Lamichhane, R., Lee, K. H., Kim, S. G., Lee, D. H., Lee, H. K., & Jung, H. J. (2019). Bioassay-guided isolation of active anti-adipogenic compound from royal jelly and the study of possible mechanisms. BMC Complement Altern Med, 19(1), 33. doi:10.1186/s12906-018-2423-2.
  • Pasupuleti, V. R., Sammugam, L., Ramesh, N., & Gan, S. H. (2017). Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits. Oxid Med Cell Longev, 2017, 1259510. doi:10.1155/2017/1259510.
  • Petelin, A., Kenig, S., Kopinc, R., Dezelak, M., Cernelic Bizjak, M., & Jenko Praznikar, Z. (2019). Effects of Royal Jelly Administration on Lipid Profile, Satiety, Inflammation, and Antioxidant Capacity in Asymptomatic Overweight Adults. Evid Based Complement Alternat Med, 2019, 4969720. doi:10.1155/2019/4969720.
  • Pourmoradian, S., Mahdavi, R., Mobasseri, M., Faramarzi, E., & Mobasseri, M. (2012). Effects of royal jelly supplementation on body weight and dietary intake in type 2 diabetic females. Health Promot Perspect, 2(2), 231-235. doi:10.5681/hpp.2012.028.
  • Ramadan, M. F., & Al-Ghamdi, A. (2012). Bioactive compounds and health-promoting properties of royal jelly: Areview. J. Funct. Foods, 4, 39-52.
  • Sun, Q., Wedick, N. M., Tworoger, S. S., Pan, A., Townsend, M. K., Cassidy, A., van Dam, R. M. (2015). Urinary Excretion of Select Dietary Polyphenol Metabolites Is Associated with a Lower Risk of Type 2 Diabetes in Proximate but Not Remote Follow-Up in a Prospective Investigation in 2 Cohorts of US Women. J Nutr, 145(6), 1280-1288. doi:10.3945/jn.114.208736.
  • Suzuki, K. M., Isohama, Y., Maruyama, H., Yamada, Y., Narita, Y., Ohta, S., Mishima, S. (2008). Estrogenic activities of Fatty acids and a sterol isolated from royal jelly. Evid Based Complement Alternat Med, 5(3), 295-302. doi:10.1093/ecam/nem036.
  • Thomas, J. (2020). Obesity and Weight Loss Therapy: Appealing for Researchers Contribution. J Obes Weight Loss Ther, 10, 401. doi:10.4172/2165-7904.1000401.
  • Willson, R. B. (1955). Royal Jelly: A Review. Part 1-The Scientific Aspects. American Bee Journal, 95, 16-19.
  • Yarmolinsky, J., Mueller, N. T., Duncan, B. B., Bisi Molina Mdel, C., Goulart, A. C., & Schmidt, M. I. (2015). Coffee Consumption, Newly Diagnosed Diabetes, and Other Alterations in Glucose Homeostasis: A Cross-Sectional Analysis of the Longitudinal Study of Adult Health (ELSA-Brasil). PLoS One, 10(5), e0126469. doi:10.1371/journal.pone.0126469.
  • Yoneshiro, T., Kaede, R., Nagaya, K., Aoyama, J., Saito, M., Okamatsu-Ogura, Y., Terao, A. (2018). Royal jelly ameliorates diet-induced obesity and glucose intolerance by promoting brown adipose tissue thermogenesis in mice. Obes Res Clin Pract, 12(Suppl 2), 127-137. doi:10.1016/j.orcp.2016.12.006
  • Yoshida, M., Hayashi, K., Watadani, R., Okano, Y., Tanimura, K., Kotoh, J.,. Maeda, A. (2017). Royal jelly improves hyperglycemia in obese/diabetic KK-Ay mice. J Vet Med Sci, 79(2), 299-307. doi:10.1292/jvms.16-0458.
  • You, M. M., Liu, Y. C., Chen, Y. F., Pan, Y. M., Miao, Z. N., Shi, Y. Z.,. Hu, F. L. (2020). Royal jelly attenuates nonalcoholic fatty liver disease by inhibiting oxidative stress and regulating the expression of circadian genes in ovariectomized rats. J Food Biochem, 44(3), e13138. doi:10.1111/jfbc.13138.

EFFECTS OF ROYAL JELLY ON OBESITY

Year 2022, , 87 - 95, 19.05.2022
https://doi.org/10.31467/uluaricilik.1058101

Abstract

Obesity is a disease that affects people's quality of life and is a risk factor for some fatal diseases. Its prevalence is increasing in the world and the biggest factor is nutritional problems and a sedentary lifestyle. Royal jelly (RJ), a natural product for obesity, a preventable disease, has been the subject of various studies. RJ secreted by young honey bees (worker bees) is the only food source for the queen bee and the first three days of food for immature bees. Several studies have shown RJ's anti-obesity, antioxidant, anticarcinogenic, antimicrobial, and anti-inflammatory activities. In addition, RJ is seen as a promising functional food in the prevention of obesity and protection from its negative effects. This study is an examination of studies on the effects of RJ on obesity and its accompanying problems.

Supporting Institution

Bu çalışma bir kurum tarafından desteklenmemektedir

Thanks

The authors would like to thank the Council of Higher Education (CoHE) for the 100/2000 CoHE Doctorate Scholarship and The Scientific And Technological Research Council of Turkey for the 2211/A pH.D. Scholarship Programs.

References

  • Ali, A. M., & Kunugi, H. (2020). Apitherapy for Age-Related Skeletal Muscle Dysfunction (Sarcopenia): A Review on the Effects of Royal Jelly, Propolis, and Bee Pollen. Foods, 9(10). doi:10.3390/foods9101362.
  • Alvehus, M., Burén, J., Sjöström, M., Goedecke, J., & Olsson, T. The human visceral fat depot has a unique inflammatory profile. Obesity (Silver Spring), 18(5), 879-883. doi:10.1038/oby.2010.22.
  • Barker, S. A., Foster, A. B., Lamb, D. C., & Hodgson, N. (1959). Identification of 10-hydroxy-delta 2-decenoic acid in royal jelly. Nature, 183(4666), 996-997. doi:10.1038/183996a0.
  • Chen, Y. F., You, M. M., Liu, Y. C., Shi, Y. Z., Wang, K., Lu, Y. Y., & Hu, F. L. (2018). Potential protective effect of Trans-10-hydroxy-2-decenoic acid on the inflammation induced by Lipoteichoic acid. J. Funct. Foods, 45, 491-498.
  • Crane, E. (1990). Bees and Beekeeping, Practice and World Resources. Oxford, London: Heinemann Professional Publishing Ltd.
  • Dixit, P. K., & Patel, N. G. (1964). Insulin-Like Activity in Larval Foods of the Honeybee. Nature, 202, 189-190. doi:10.1038/202189a0.
  • Fratini, F., Cilia, G., Mancini, S., & Felicioli, A. (2016). Royal Jelly: An ancient remedy with remarkable antibacterial properties. Microbiol Res, 192, 130-141. doi:10.1016/j.micres.2016.06.007.
  • Irandoost, P., Mesri Alamdari, N., Saidpour, A., Shidfar, F., Farsi, F., Asghari Jafarabadi, M., Vafa, M. (2020). The effect of royal jelly and tocotrienol-rich fraction along with calorie restriction on hypothalamic endoplasmic reticulum stress and adipose tissue inflammation in diet-induced obese rats. BMC Res Notes, 13(1), 409. doi:10.1186/s13104-020-05258-0.
  • Irandoost, P., Mesri Alamdari, N., Saidpour, A., Shidfar, F., Roshanravan, N., Asghari Jafarabadi, M., Vafa, M. (2020). The effects of royal jelly and tocotrienol-rich fraction on impaired glycemic control and inflammation through irisin in obese rats. J Food Biochem, 44(12), e13493. doi:10.1111/jfbc.13493.
  • Isidorov, V. A., Bakier, S., & Grzech, I. (2012). Gas chromatographic-mass spectrometric investigation of volatile and extractable compounds of crude royal jelly. J Chromatogr B Analyt Technol Biomed Life Sci, 885-886, 109-116. doi:10.1016/j.jchromb.2011.12.025.
  • Kamakura, M. (2011). Royalactin induces queen differentiation in honeybees. Nature, 473(7348), 478-483. doi:10.1038/nature10093.
  • Kanelis, D., Tananaki, C., Liolios, V., Rodopoulou, M. A., Goras, G., Argena, N., & Thrasyvoulou, A. (2018). Investigating the Effect of Supplementary Feeding on Carbohydrate Composition and Quantity of Royal Jelly. Open Journal of Applied Sciences, 8, 141-149. doi:10.4236/ojapps.2018.84011.
  • Knekt, P., Kumpulainen, J., Jarvinen, R., Rissanen, H., Heliovaara, M., Reunanen, A., Aromaa, A. (2002). Flavonoid intake and risk of chronic diseases. The American Journal of Clinical Nutrition, 76, 560-568.
  • Kramer, K. J., Tager, H. S., Childs, C. N., & Speirs, R. D. (1977). Insulin-like hypoglycemic and immunological activities in honeybee royal jelly. J Insect Physiol, 23(2), 293-295. doi:10.1016/0022-1910(77)90044-0.
  • Kunugi, H., & Mohammed Ali, A. (2019). Royal Jelly and Its Components Promote Healthy Aging and Longevity: From Animal Models to Humans. Int J Mol Sci, 20(19). doi:10.3390/ijms20194662.
  • Li, K., Liu, C., Wahlqvist, M. L., & Li, D. (2020). Econutrition, brown and beige fat tissue and obesity. Asia Pacific Journal of Clinical Nutrition, 29(4), 668-680. doi:10.6133/apjcn.202012_29(4).0001.
  • Lin, C.-M., Chen, C.-T., Lee, H.-H., & Lin, J.-K. (2002). Prevention of cellular ROS damage by isovitexin and related flavonoids. Planta medica, 68(04), 365-367.
  • Manach, C., Scalbert, A., Morand, C., Remesy, C., & Jimenez, L. (2004). Polyphenols: Food sources and bioavailability. The American Journal of Clinical Nutrition, 79, 727-747. doi:10.1093/ajcn/79.5.727.
  • Mesri Alamdari, N., Irandoost, P., Roshanravan, N., Vafa, M., Jafarabadi, M. A., Alipour, S., Shidfar, F. (2020). Effects of Royal Jelly and Tocotrienol Rich Fraction in obesity treatment of calorie-restricted obese rats: a focus on white fat browning properties and thermogenic capacity. Nutr Metab (Lond), 17, 42. doi:https://doi.org/10.1186/s12986-020-00458-8.
  • Metwally Ibrahim, S. E. L., & Kosba, A. A. (2018). Royal jelly supplementation reduces skeletal muscle lipotoxicity and insulin resistance in aged obese rats. Pathophysiology, 25(4), 307-315. doi:10.1016/j.pathophys.2018.05.001.
  • Mihajlovic, D., Rajkovic, I., Chinou, I., & Colic, M. (2013). Dose-dependent immunomodulatory effects of 10-hydroxy-2-decenoic acid on human monocyte-derived dendritic cells. J. Funct. Foods, 5, 838-846.
  • Moutsatsou, P., Papoutsi, Z., Kassi, E., Heldring, N., Zhao, C., Tsiapara, A., Dahlman-Wright, K. (2010). Fatty acids derived from royal jelly are modulators of estrogen receptor functions. PLoS One, 5(12), e15594. doi:10.1371/journal.pone.0015594.
  • Pandey, K. B., & Rizvi, S. I. (2009). Plant polyphenols as dietary antioxidants in human health and disease. Oxidative Medicine and Cellular Longevity, 2, 270-278. doi:10.4161/oxim.2.5.9498.
  • Pandeya, P. R., Lamichhane, R., Lee, K. H., Kim, S. G., Lee, D. H., Lee, H. K., & Jung, H. J. (2019). Bioassay-guided isolation of active anti-adipogenic compound from royal jelly and the study of possible mechanisms. BMC Complement Altern Med, 19(1), 33. doi:10.1186/s12906-018-2423-2.
  • Pasupuleti, V. R., Sammugam, L., Ramesh, N., & Gan, S. H. (2017). Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits. Oxid Med Cell Longev, 2017, 1259510. doi:10.1155/2017/1259510.
  • Petelin, A., Kenig, S., Kopinc, R., Dezelak, M., Cernelic Bizjak, M., & Jenko Praznikar, Z. (2019). Effects of Royal Jelly Administration on Lipid Profile, Satiety, Inflammation, and Antioxidant Capacity in Asymptomatic Overweight Adults. Evid Based Complement Alternat Med, 2019, 4969720. doi:10.1155/2019/4969720.
  • Pourmoradian, S., Mahdavi, R., Mobasseri, M., Faramarzi, E., & Mobasseri, M. (2012). Effects of royal jelly supplementation on body weight and dietary intake in type 2 diabetic females. Health Promot Perspect, 2(2), 231-235. doi:10.5681/hpp.2012.028.
  • Ramadan, M. F., & Al-Ghamdi, A. (2012). Bioactive compounds and health-promoting properties of royal jelly: Areview. J. Funct. Foods, 4, 39-52.
  • Sun, Q., Wedick, N. M., Tworoger, S. S., Pan, A., Townsend, M. K., Cassidy, A., van Dam, R. M. (2015). Urinary Excretion of Select Dietary Polyphenol Metabolites Is Associated with a Lower Risk of Type 2 Diabetes in Proximate but Not Remote Follow-Up in a Prospective Investigation in 2 Cohorts of US Women. J Nutr, 145(6), 1280-1288. doi:10.3945/jn.114.208736.
  • Suzuki, K. M., Isohama, Y., Maruyama, H., Yamada, Y., Narita, Y., Ohta, S., Mishima, S. (2008). Estrogenic activities of Fatty acids and a sterol isolated from royal jelly. Evid Based Complement Alternat Med, 5(3), 295-302. doi:10.1093/ecam/nem036.
  • Thomas, J. (2020). Obesity and Weight Loss Therapy: Appealing for Researchers Contribution. J Obes Weight Loss Ther, 10, 401. doi:10.4172/2165-7904.1000401.
  • Willson, R. B. (1955). Royal Jelly: A Review. Part 1-The Scientific Aspects. American Bee Journal, 95, 16-19.
  • Yarmolinsky, J., Mueller, N. T., Duncan, B. B., Bisi Molina Mdel, C., Goulart, A. C., & Schmidt, M. I. (2015). Coffee Consumption, Newly Diagnosed Diabetes, and Other Alterations in Glucose Homeostasis: A Cross-Sectional Analysis of the Longitudinal Study of Adult Health (ELSA-Brasil). PLoS One, 10(5), e0126469. doi:10.1371/journal.pone.0126469.
  • Yoneshiro, T., Kaede, R., Nagaya, K., Aoyama, J., Saito, M., Okamatsu-Ogura, Y., Terao, A. (2018). Royal jelly ameliorates diet-induced obesity and glucose intolerance by promoting brown adipose tissue thermogenesis in mice. Obes Res Clin Pract, 12(Suppl 2), 127-137. doi:10.1016/j.orcp.2016.12.006
  • Yoshida, M., Hayashi, K., Watadani, R., Okano, Y., Tanimura, K., Kotoh, J.,. Maeda, A. (2017). Royal jelly improves hyperglycemia in obese/diabetic KK-Ay mice. J Vet Med Sci, 79(2), 299-307. doi:10.1292/jvms.16-0458.
  • You, M. M., Liu, Y. C., Chen, Y. F., Pan, Y. M., Miao, Z. N., Shi, Y. Z.,. Hu, F. L. (2020). Royal jelly attenuates nonalcoholic fatty liver disease by inhibiting oxidative stress and regulating the expression of circadian genes in ovariectomized rats. J Food Biochem, 44(3), e13138. doi:10.1111/jfbc.13138.
There are 36 citations in total.

Details

Primary Language English
Subjects Food Engineering
Journal Section Review
Authors

Aslıhan Demirkaya 0000-0002-8219-0412

Gulcin Sagdicoglu Celep 0000-0002-4598-5814

Publication Date May 19, 2022
Acceptance Date April 14, 2022
Published in Issue Year 2022

Cite

Vancouver Demirkaya A, Sagdicoglu Celep G. EFFECTS OF ROYAL JELLY ON OBESITY. U.Arı D.-U.Bee J. 2022;22(1):87-95.

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