Review
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Propolisin Sağlık Açısından Önemi, Kalitesinin Belirlenmesi Ve Türkiye Açısından İrdelenmesi

Year 2014, Volume: 14 Issue: 1, 35 - 43, 29.05.2014
https://doi.org/10.31467/uluaricilik.376728

Abstract

Propolisin içinde 300’den fazla aktif madde bulunmaktadır. Bunların içinde insan sağlığı açısından
önemli olanlar fenolik bileşiklerdir ve fenolik bileşiklerden de özellikle bazı fenolik asitler ve flavanoidlerdir.
Kaynağına ve dolayısıyla içeriğine bağlı olarak, propolisin antimikrobiyal (bakteri, virüs, parazit
ve mantarlara karşı), antioksidan, antiinflamatuar, antikanser ve ülser önleyici gibi etkileri bulunmaktadır.
Bu etkiler propolisin içeriğine bağlı olarak değişebilmekte ve yine içeriğine bağlı olarak
propolisin zararlı etkileri de görülebilmektedir. Bu nedenle propolislerin bilinçli toplanması, uygun bir
şekilde ekstraktlarının hazırlanması, içerik analizlerinin yapılması ve tüketime sunulması gerekir. Bu
şekilde hazırlanan propolis ekstraklarının kaliteleri belirlenebilecek ve belirli bir oranda standardize
edilebilecektir. Böylece tüketime sunulan propolislerin içindeki yararlı maddeler ve miktarlarının bilinmesiyle
istenilen yararlı etkilerinin görülmesine katkı sağlanmış olacaktır. Bu anlamda Türkiye’deki
propolislerin de ele alınması ve içerik miktarları açısından irdelenmesi gerekmektedir.

References

  • Abdel-Wahab, M.H., El-Mahdy, M.A., Abd-Ellah, M.F., Helal, G.K., Khalifa, F, Hamada, F.M. 2003. Influence of p-coumaric acid on doxorubicin-induced oxidative stress in rat’s heart, Pharmacol. Res.,48:461–465.
  • Ahn, M.R., Kumazawa, S., Usui, Y., Nakamura, J., Matsuka, M., Zhu, F., Nakayama, T. 2007. Anti-oxidant activity and constituents of propolis collected in various areas of China. Food Chem., 101: 1383–1392.
  • Akao, Y., Maruyama, H., Matsumoto, K., Ohguchi, K., Nishizawa, K., Sakamoto, T., Araki, Y., Mishima, S., Nozawa, Y. 2003. Cell growth inhibitory effect of cinnamic acid derivatives from propolis on human tumor cell lines. Biol. Pharm. Bull., 26: 1057–1059.
  • Bankova, V., Boudourova, K.G., Popova, S. 1998.Seasonal variations in essential oil from Brazilian propolis.J.Essent. Oil Res.,10: 693-696.
  • Bankova, V., Dyulgerov A., Popov S., Evstatieva L., Kuleva L., Pureb O., Zamjansan Z. 1992. Propolis produced in Bulgaria and Mongolia phenolic composition and plant origin. Apidologie, 23: 79-85.
  • Bankova, V.S., De Castro S.L., Marcucci M.C. 2000. Propolis: recent advances in chemistry and plant origin. Apidologie, 31: 3-15.
  • Banskota, A.H., Tezuka, Y., Kadota, S. 2001. Recent progress in pharmacological research of pro-polis.Phytother. Res., 15: 561–571.
  • Barros, M.P., Lemos, M., Maistro, E.L., Leite, M.F., Sousa, J.P., Bastos, J.K., Andrade, S.F., 2008.Evaluation of antiulcer activity of the main phenolic acids found in Brazilian green propolis.J. Ethnopharmacol., 120: 372–377.
  • Bonvehi, J.S., Coll F.V. 2000. Study on propolis quality from China and Uruguay. Zeitschrift für Naturforsch C, 55: 778-784.
  • Burdock, GA. 1998. Review of the biological properties and toxicity of bee propolis (propolis). Food. Chem. Toxicol., 36: 347-363.
  • Calderon-Montano, J.M., Burgos-Moron, E., Perez-Guerrero, C., Lopez-Lazaro, M.A. 2011. Review on the dietary flavonoid kaempferol. Mini-Rev. Med. Chem., 11: 298-344.
  • Chao, C.L., Weng, C.S., Chang, N.C., Lin, J.S., Kao, S.T., Ho, F.M. 2010. Naringenin more effec-tively inhibits inducible nitric oxide synthase and cyclooxygenase-2 expression inmacrophages than in microglia. Nutrition Research, 30: 858–864.
  • Chen, A.Y.,Chen, Y.C., 2013. A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention. Food Chem., 138:2099-107
  • Choi, Y.M., Noh, D.O., Cho, S.Y., Suh, H.J., Kim, K.M., Kim, J.M. 2006.Antioxidant and antimicrobial activities of propolis from several regions of Korea.LWT-Food Sci. Technol., 39: 756–761.
  • Chung, T.W., Moon, S.K., Chang, Y.C., Ko, J.H., Lee, Y.C., Cho, G., Kim, S.H., Kim, J.G., Kim, C.H.2004. Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarci-noma cells: complete regression of hepatoma growth and metastasis by dual mechanism. FASEB J., 18: 1670-1681.
  • Cushnie, T.P.T., Lamb A.J. 2005. Antimicrobial activity of flavonoids.Int. J. Antimicrob. Agents, 26: 343-356.
  • Çelemli, Ö.G., Salih B. 2009. GC-MS Analysis of propolis samples from 17 different regions of Turkey, four different regions of Brazil and one from Japan. Mellifera, 9: 19-28.
  • Çelemli, Ö.G.2010. Tekirdağ bölgesi propolis örneklerinin flavonoid, karboksilik asit ve türevlerinin izolasyon yöntemlerinin geliştirilmesi ve mikroskobik analizi, (Doktora tezi), Hacettepe Üniversitesi, Biyoloji Anabilim Dalı.
  • De Castro, S.L. 2001. Propolis: Biological and pharmacological activities. therpeutic uses of this bee-product. ARBS Ann. Rev. Biomed. Sci., 3, 49-83.
  • Du, G., Jin, L., Han, X., Song, Z., Zhang, H., Liang, W. 2009. Naringenin: a potential immunomodulator for inhibiting lung fibrosis and metastasis. Cancer Research, 69: 3205–3212.
  • Erdogan, S., Ates B., Durmaz G., Yilmaz I., Seckin T. 2011.Pressurized liquid extraction of phenolic compounds from Anatolia propolis and their radical scavenging capacities. Food Chem. Toxicol., 49: 1592-1597.
  • Fesen, M.R., Pommier, Y., Leteurtre, F., Hiroguchi, S., Yung, J., Kohn, K.W. 1994.Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related com-pounds.Biochem.Pharmacol., 48: 595–608.
  • Fischer, G., Conceição, F.R., Leite, F.P.L., Dummer, L.A., Vargas, G.D., Hübner, S. O., Dellagostin, O. A., Paulino, N., Paulino, A. S., Vidor, T. 2007. Immunomodulation produced by a green propolis extract on humoral and cellular responses of mice immunized with SuHV-1. Vaccine, 25: 1250–1256.
  • Gardana, C., Scaglianti, M., Pietta, P., Simonetti, P. 2007. Analysis of the polyphenolic fraction of propolis from different sources by liquid chromatography–tandem mass spectrometry.J.Pharm. Bio-med. Anal., 45: 390–399.
  • Gekker, G., Hu, S., Spivak, M., Lokensgard, J.R., Peterson, P.K. 2005. Anti- HIV-1 activity of propolis in CD4(+) lymphocyte and microglial cell cultures. J. Ethnopharmacol., 102: 158–163.
  • Ghisalberti, E.L. 1979. Propolis.Bee World, 60: 59-84,
  • Gülçin, I., Bursal, E., Şehitoğlu, M.H., Bilsel, M., Gören, A.C. 2010. Polyphenol contents and antioxi-dant activity of lyophilized aqueous extract of propolis from Erzurum, Turkey. Food. Chem. Toxi-col.,48: 2227–2238.
  • Harish, Z., Rubinstein, A., Golodner, M., Elmaliah, M., Mizrachi, Y. 1997.Suppression of HIV-1 repli-cation by propolis and its immunoregulatory effect.Drugs Exp. Clin. Res., 23: 89–96.
  • Hu, F., Hepburn, H.R., Li, Y., Chen, M., Radloff, S.E., Daya, S. 2005. Effects of ethanol and water extracts of propolis (bee glue) on acute inflammatory animal models.J.Ethnopharmacol., 100: 276–283.
  • Isla, M.I., Zampini, I.C., Ordóñez, R.M., Cuello, S., Juárez, B.C., Sayago, J.E., Moreno, M.I., Al-berto, M.R., Vera, N.R., Bedascarrasbure E., Alvarez A., Cioccini F., Maldonado L.M. 2009. Effect of seasonal variations and collection form on antioxidant activity of propolis from San Juan, Argentina. J. Med. Food, 12: 1334-1342.
  • Janbaz, K.H., Saeed, S.A., Gilani, A.H. 2002. Protective effect of rutin on paracetamol- and CCl4-induced hepatotoxicity in rodents.Fitoterapia, 73: 557-563.
  • Jiang, L., Fang, G., Zhang, Y., Cao, G., Wang, S. 2008. Analysis of flavonoids in propolis and Ginkgo biloba by micellar electrokinetic capillary chromatography. J. Agric. Food Chem. 56: 11571-11577.
  • Kamalakkannan, N., Prince, P.S.M. 2006. Antihyperglycaemic and antioxidant effect of rutin, a poly-phenolic flavonoid, in streptozotocin-induced diabetic wistar rats. Basic Clin.Pharmacol.Toxicol., 98: 97–103.
  • Kampa, M., Alexaki, V.I., Notas, G., Nifli, A.P., Nistikaki, A., Hatzoglou, A., Bakogeorgou, E., Kouimtzoglou, E., Blekas, G., Boskou, D. et al. 2004. Antiproliferative and apoptotic effects of selective phenolic acids on T47D human breast cancer cells: potential mechanisms of action. Breast Cancer Res.,6:63–74.
  • Kanski, J., Aksenova, M., Soyanova, A., Butterfield, D.A. 2002. Ferulic acid antioxidant protection against hydroxyl and peroxyl radical oxidation in synaptosomal and neuronal cell culture systems in vitro: structure-activity studies. J. Nutr. Biochem.,13: 273–281.
  • Kartal, M., Kaya, S., Kurucu, S. 2002. GC-MS analysis of propolis samples from two different regions of Turkey. Z. Naturforsch., 57: 905-909.
  • Katırcıoğlu, H., Mercan, N. 2006. Antimicrobial activity and chemical compositions of Turkish propolis from different regions.African Journal of Biotechnology, 5: 1151-1153.
  • Lin, Y., Shi, R., Wang, X., Shen, H.M. 2008. Luteolin, a flavonoid with potential for cancer pre-vention and therapy. Curr.Cancer Drug Tar., 8: 634-646.
  • Liu, R., Gao, M., Yang, Z.H., Du, G.H. 2008. Pinocembrin protects rat brain against oxidation and apoptosis induced by ischemia-reperfusion both in vivo and in vitro. Brain Res.,24: 104-115.
  • Long, X., Fan, M., Bigsby, R.M., Nephew, K.P. 2008. Apigenin inhibits antiestrogen-resistant breast cancer cell growth through estrogen receptor-A-dependent and estrogen receptor-A-independent mechanisms. Mol. Cancer Ther.,7: 2096-2108.
  • Marcucci, M.C., Ferreres, F., Viguera, C.G., Bankova, V.S., De Castro, S.L., Dantas, A.P., Valente, P.H.M., Paulino, N. 2001. Phenolic compounds from Brazilian propolis with pharmacological activities. J.Ethnopharmacol., 74: 105–112.
  • Márquez, N., Sancho, R., Macho, A., Calzado, M.A., Fiebich, B.L., Muñoz, E. 2004. Caffeic acid phenethyl ester inhibits T-cell activation by targeting both nuclear factor of activated T-cells and NF-kappaB transcription factors. J. Pharmacol. Exp. Ther., 308: 993–1001.
  • Mendonça, I.C.G., Medeiros, M.L.B.B., Penteado, R.A.P.M., Parolia, A., Porto, I.C.C.M. 2013.An overview of the toxic effects and allergic reactions caused by propolis. PharmacologyOnLine, 2: 96-105.
  • Menniti-Ippolito, F, Mazzanti, G, Vitalone A, Firenzuoli, F, Santuccio, C. 2008. Surveillance of suspected adverse reactions to natural health products: the case of propolis. Drug Saf., 31: 419-423.
  • Narayana, K.R., Reddy, M.S., Chaluvadi, M.R., Krishna, D.R. 2001.Bioflavanoids classification, pharmacological, biochemical effects and therapeutic potential.Indian J. Pharmacology, 33: 2-16.
  • Okutan, H., Ozcelik, N., Yilmaz, H.R., Uz, E. 2005. Effects of caffeic acid phenethyl ester on lipid peroxidation and antioxidant enzymes in diabetic rat heart.Clin.Biochem., 38: 191–196.
  • Orsi, R.O., Sforcin, J.M., Funari, S.R.C., Fernandes Jr, A., Bankova, V. 2006. Synergistic effect of propolis and antibiotics on the Salmonella Typhi.Braz. J. Microbiol., 37: 108–112.
  • Pandey, K.B., Rizvi, S.I. 2009.Plant polyphenols as dietary antioxidants in human health and dis-ease.Oxid. Med. Cell Longev.,2:270–278.
  • Paulino, N., Teixeira, C., Martins, R., Scremin, A., Dirsch, V.M., Vollmar, A.M., Abreu, S.R., De Cas-tro, S.L., Marcucci, M.C. 2006.Evaluation of the analgesic and antiinflammatory effects of a Brazilian green propolis.Planta Medica, 72: 899–906.
  • Popova, M., Silici, S., Kaftanoglu, O., Bankova, V. 2005.Antibacterial activity of Turkish propolis and its qualitative and quantitative chemical composition.Phytomedicine, 12: 221–228.
  • Popova, M.P, Bankova, V.S, Bogdanov, S., Tsvetkova, I., Naydenski, C., Marcazzan, L.G., Sabatini, A.G.2007. Chemical characteristics of poplar type propolis of different geographic origin. Apidologie, 38: 306-311.
  • Popova, M., Bankova, V., Chimov, A., Silva, M.V.2002.A scientific note on the high toxicity of propolis that comes from Myroxylon balsamum trees.Apidologie, 33: 87–88.
  • Quiroga, E.N., Sampietro, D.A., Soberon, J.R., Sgariglia, M.A., Vattuone, M.A. 2006. Propolis from the northwest of Argentina as a source of antifungal principles.J. Appl. Microbiol., 101: 103–110.
  • Raina, K., Rajamanickam, S., Deep, G., Singh, M., Agarwal, R., Agarwal, C. 2008. Chemopreventive effects of oral gallic acid feeding on tumor growth and progression in TRAMP mice.Mol. Cancer Ther.,7:1258-1267.
  • Sahinler, N., Kaftanoglu, O. 2005. Natural product propolis: chemical composition. Nat. Prod. Res., 19:183-188.
  • 56) Sarıkaya, A.O. 2009. Kestane bal ve propolisinin fenolik asit kompozisyonu ve antioksidan özelliginin belirlenmesi, (Yüksek lisans tezi), Karadeniz Teknik Üniversitesi, Fen Bilimleri Enstitüsü.
  • Scifo, C., Cardile, V., Russo, A., Consoli, R., Vancheri, C., Capasso, F., Vanella, A., Renis, M. 2004.Resveratrol and propolis as necrosis or apoptosis inducers in human prostate carcinoma cells.Oncol. Res.,14: 415–426.
  • Seidel, V., Peyfoon, E., Watson, D.G., Fearnley, J. 2008. Comperative study of the antibacterial activity of propolis from different geographical and climatic zones. Phytother Research., 22: 1256-1263.
  • Sforcin, J.M.,2007. Propolis and the immune system: a review. J. Ethnopharmacol., 113: 1-14.
  • Silici, S., Kutluca, S. 2005. Chemical composition and antibacterial activity of propolis collected by three different races of honeybees in the same region.J.Ethnopharmacol., 99: 69-73.
  • Silici, S. 2003. Propolisin bazı antimikrobiyal ve farmakolojik aktiviteleri üzerine bir araştırma (Dokto-ra tezi), Çukurova Üniversitesi, Fen Bilimleri Enstitüsü, Zootekni Anabilim Dalı.
  • Silici, S., Koc, A.N. 2006. Comparative study of in vitro methods to analyse the antifungal activity of propolis against yeasts isolated from patients with superficial mycoses. Lett. Appl. Microbiol., 43: 318–324.
  • Sorkun, K., Stler, B., Salih, B. 2001. Determination of chemical composition of Turkish propolis. Zeitschrift für Naturforschung, 56: 666-668.
  • Sova, M.2012.Antioxidant and antimicrobial activities of cinnamic acid derivatives.Mini Rev. Med. Chem., 12: 749-767.
  • Soylu, E.M., Özdemir, A.E., Ertürk, E., Şahinler, N., Soylu, S. 2008.Chemical composition and antifungal activity of propolis against Penicillium digitatum.Asian J. Chem., 20: 4823-4830.
  • Su, Z.Z., Lin, J., Grunberger, D., Fisher, P.B. 1994. Growth suppression and toxicity induced by caf-feic acid phenethyl ester (CAPE) in type-5 adenovirus-transformed rat embryo cells correlate directly with transformation progression. Cancer Res., 54: 1865–1870.
  • Szliszka, E., Czuba, Z.P., Domino, M., Mazur, B., Zydowicz, G., Krol, W. 2009. Ethanolic extract of propolis (EEP) enhances the apoptosis-inducing potential of TRAIL in cancer cells. Molecules, 14: 738-754.
  • Trusheva, B., Trunkova, D., Bankova, V. 2007. Different extraction methods of biologically active components from propolis: a preliminary study.Chem. Cen. J. 7: 1-13.
  • Tsai, S.J., Huang, C.S., Mong, M.C., Kam, W.Y., Huang, H.Y., Yin, M.C. 2012. Anti-inflammatory and antifibrotic effects of naringenin in diabetic mice.J. Agric. Food Chem., 60: 514–521.
  • Ünlü, G.V., Silici, S., Ünlü, M. 2008. Composition and in vitro antimicrobial activity of Populus buds and poplar-type propolis. World J. Microbiol. Biotechnol., 24: 1011–1017.
  • Vafeiadou, K., Vauzour, D., Lee, H.Y., Rodriguez-Mateos, A., Williams, R.J., Spencer, J.P.E. 2009. The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury. Archiv.Biochem.Biophys., 484: 100–109.
  • Velazquez, C., Navarro, M., Acosta, A., Angulo, A., Dominguez, Z., Roble, R., Robles-Zepeda, R., Lugo, E., Goycoolea, F.M., Velazquez, E.F. et al. 2007.Antibacterial and free-radical scavenging ac-tivities of Sonoran propolis.J. Appl. Microbiol., 103: 1747–1756.
  • Velikova, M., Bankova, V., Marcucci, M., Tsvetkova, I., Kujungiev, A. 2000.Chemical Composition and Biological Activity of Propolis from Brazilian Meliponinae.Z. Naturforsch C., 55: 785-789.
  • Wollenweber, E, Hausen, B.M., Greenaway, W. 1990. Phenolic constituents and sensitizing properties of propolis, poplar balsam and balsam of Peru.Bull. Groupe Polyphenols, 15: 112–120.
  • Xiang, D.B., Wang, D., He, Y.J., Xie, J., Zhong, Z.Y., Li, Z.P. 2006. Caffeic acid phenethyl ester in-duces growth arrest and apoptosis of colon cancer cells via the betacatenin ⁄ T-cell factor signaling. Anticancer Drugs, 17: 753–762.
Year 2014, Volume: 14 Issue: 1, 35 - 43, 29.05.2014
https://doi.org/10.31467/uluaricilik.376728

Abstract

References

  • Abdel-Wahab, M.H., El-Mahdy, M.A., Abd-Ellah, M.F., Helal, G.K., Khalifa, F, Hamada, F.M. 2003. Influence of p-coumaric acid on doxorubicin-induced oxidative stress in rat’s heart, Pharmacol. Res.,48:461–465.
  • Ahn, M.R., Kumazawa, S., Usui, Y., Nakamura, J., Matsuka, M., Zhu, F., Nakayama, T. 2007. Anti-oxidant activity and constituents of propolis collected in various areas of China. Food Chem., 101: 1383–1392.
  • Akao, Y., Maruyama, H., Matsumoto, K., Ohguchi, K., Nishizawa, K., Sakamoto, T., Araki, Y., Mishima, S., Nozawa, Y. 2003. Cell growth inhibitory effect of cinnamic acid derivatives from propolis on human tumor cell lines. Biol. Pharm. Bull., 26: 1057–1059.
  • Bankova, V., Boudourova, K.G., Popova, S. 1998.Seasonal variations in essential oil from Brazilian propolis.J.Essent. Oil Res.,10: 693-696.
  • Bankova, V., Dyulgerov A., Popov S., Evstatieva L., Kuleva L., Pureb O., Zamjansan Z. 1992. Propolis produced in Bulgaria and Mongolia phenolic composition and plant origin. Apidologie, 23: 79-85.
  • Bankova, V.S., De Castro S.L., Marcucci M.C. 2000. Propolis: recent advances in chemistry and plant origin. Apidologie, 31: 3-15.
  • Banskota, A.H., Tezuka, Y., Kadota, S. 2001. Recent progress in pharmacological research of pro-polis.Phytother. Res., 15: 561–571.
  • Barros, M.P., Lemos, M., Maistro, E.L., Leite, M.F., Sousa, J.P., Bastos, J.K., Andrade, S.F., 2008.Evaluation of antiulcer activity of the main phenolic acids found in Brazilian green propolis.J. Ethnopharmacol., 120: 372–377.
  • Bonvehi, J.S., Coll F.V. 2000. Study on propolis quality from China and Uruguay. Zeitschrift für Naturforsch C, 55: 778-784.
  • Burdock, GA. 1998. Review of the biological properties and toxicity of bee propolis (propolis). Food. Chem. Toxicol., 36: 347-363.
  • Calderon-Montano, J.M., Burgos-Moron, E., Perez-Guerrero, C., Lopez-Lazaro, M.A. 2011. Review on the dietary flavonoid kaempferol. Mini-Rev. Med. Chem., 11: 298-344.
  • Chao, C.L., Weng, C.S., Chang, N.C., Lin, J.S., Kao, S.T., Ho, F.M. 2010. Naringenin more effec-tively inhibits inducible nitric oxide synthase and cyclooxygenase-2 expression inmacrophages than in microglia. Nutrition Research, 30: 858–864.
  • Chen, A.Y.,Chen, Y.C., 2013. A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention. Food Chem., 138:2099-107
  • Choi, Y.M., Noh, D.O., Cho, S.Y., Suh, H.J., Kim, K.M., Kim, J.M. 2006.Antioxidant and antimicrobial activities of propolis from several regions of Korea.LWT-Food Sci. Technol., 39: 756–761.
  • Chung, T.W., Moon, S.K., Chang, Y.C., Ko, J.H., Lee, Y.C., Cho, G., Kim, S.H., Kim, J.G., Kim, C.H.2004. Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarci-noma cells: complete regression of hepatoma growth and metastasis by dual mechanism. FASEB J., 18: 1670-1681.
  • Cushnie, T.P.T., Lamb A.J. 2005. Antimicrobial activity of flavonoids.Int. J. Antimicrob. Agents, 26: 343-356.
  • Çelemli, Ö.G., Salih B. 2009. GC-MS Analysis of propolis samples from 17 different regions of Turkey, four different regions of Brazil and one from Japan. Mellifera, 9: 19-28.
  • Çelemli, Ö.G.2010. Tekirdağ bölgesi propolis örneklerinin flavonoid, karboksilik asit ve türevlerinin izolasyon yöntemlerinin geliştirilmesi ve mikroskobik analizi, (Doktora tezi), Hacettepe Üniversitesi, Biyoloji Anabilim Dalı.
  • De Castro, S.L. 2001. Propolis: Biological and pharmacological activities. therpeutic uses of this bee-product. ARBS Ann. Rev. Biomed. Sci., 3, 49-83.
  • Du, G., Jin, L., Han, X., Song, Z., Zhang, H., Liang, W. 2009. Naringenin: a potential immunomodulator for inhibiting lung fibrosis and metastasis. Cancer Research, 69: 3205–3212.
  • Erdogan, S., Ates B., Durmaz G., Yilmaz I., Seckin T. 2011.Pressurized liquid extraction of phenolic compounds from Anatolia propolis and their radical scavenging capacities. Food Chem. Toxicol., 49: 1592-1597.
  • Fesen, M.R., Pommier, Y., Leteurtre, F., Hiroguchi, S., Yung, J., Kohn, K.W. 1994.Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related com-pounds.Biochem.Pharmacol., 48: 595–608.
  • Fischer, G., Conceição, F.R., Leite, F.P.L., Dummer, L.A., Vargas, G.D., Hübner, S. O., Dellagostin, O. A., Paulino, N., Paulino, A. S., Vidor, T. 2007. Immunomodulation produced by a green propolis extract on humoral and cellular responses of mice immunized with SuHV-1. Vaccine, 25: 1250–1256.
  • Gardana, C., Scaglianti, M., Pietta, P., Simonetti, P. 2007. Analysis of the polyphenolic fraction of propolis from different sources by liquid chromatography–tandem mass spectrometry.J.Pharm. Bio-med. Anal., 45: 390–399.
  • Gekker, G., Hu, S., Spivak, M., Lokensgard, J.R., Peterson, P.K. 2005. Anti- HIV-1 activity of propolis in CD4(+) lymphocyte and microglial cell cultures. J. Ethnopharmacol., 102: 158–163.
  • Ghisalberti, E.L. 1979. Propolis.Bee World, 60: 59-84,
  • Gülçin, I., Bursal, E., Şehitoğlu, M.H., Bilsel, M., Gören, A.C. 2010. Polyphenol contents and antioxi-dant activity of lyophilized aqueous extract of propolis from Erzurum, Turkey. Food. Chem. Toxi-col.,48: 2227–2238.
  • Harish, Z., Rubinstein, A., Golodner, M., Elmaliah, M., Mizrachi, Y. 1997.Suppression of HIV-1 repli-cation by propolis and its immunoregulatory effect.Drugs Exp. Clin. Res., 23: 89–96.
  • Hu, F., Hepburn, H.R., Li, Y., Chen, M., Radloff, S.E., Daya, S. 2005. Effects of ethanol and water extracts of propolis (bee glue) on acute inflammatory animal models.J.Ethnopharmacol., 100: 276–283.
  • Isla, M.I., Zampini, I.C., Ordóñez, R.M., Cuello, S., Juárez, B.C., Sayago, J.E., Moreno, M.I., Al-berto, M.R., Vera, N.R., Bedascarrasbure E., Alvarez A., Cioccini F., Maldonado L.M. 2009. Effect of seasonal variations and collection form on antioxidant activity of propolis from San Juan, Argentina. J. Med. Food, 12: 1334-1342.
  • Janbaz, K.H., Saeed, S.A., Gilani, A.H. 2002. Protective effect of rutin on paracetamol- and CCl4-induced hepatotoxicity in rodents.Fitoterapia, 73: 557-563.
  • Jiang, L., Fang, G., Zhang, Y., Cao, G., Wang, S. 2008. Analysis of flavonoids in propolis and Ginkgo biloba by micellar electrokinetic capillary chromatography. J. Agric. Food Chem. 56: 11571-11577.
  • Kamalakkannan, N., Prince, P.S.M. 2006. Antihyperglycaemic and antioxidant effect of rutin, a poly-phenolic flavonoid, in streptozotocin-induced diabetic wistar rats. Basic Clin.Pharmacol.Toxicol., 98: 97–103.
  • Kampa, M., Alexaki, V.I., Notas, G., Nifli, A.P., Nistikaki, A., Hatzoglou, A., Bakogeorgou, E., Kouimtzoglou, E., Blekas, G., Boskou, D. et al. 2004. Antiproliferative and apoptotic effects of selective phenolic acids on T47D human breast cancer cells: potential mechanisms of action. Breast Cancer Res.,6:63–74.
  • Kanski, J., Aksenova, M., Soyanova, A., Butterfield, D.A. 2002. Ferulic acid antioxidant protection against hydroxyl and peroxyl radical oxidation in synaptosomal and neuronal cell culture systems in vitro: structure-activity studies. J. Nutr. Biochem.,13: 273–281.
  • Kartal, M., Kaya, S., Kurucu, S. 2002. GC-MS analysis of propolis samples from two different regions of Turkey. Z. Naturforsch., 57: 905-909.
  • Katırcıoğlu, H., Mercan, N. 2006. Antimicrobial activity and chemical compositions of Turkish propolis from different regions.African Journal of Biotechnology, 5: 1151-1153.
  • Lin, Y., Shi, R., Wang, X., Shen, H.M. 2008. Luteolin, a flavonoid with potential for cancer pre-vention and therapy. Curr.Cancer Drug Tar., 8: 634-646.
  • Liu, R., Gao, M., Yang, Z.H., Du, G.H. 2008. Pinocembrin protects rat brain against oxidation and apoptosis induced by ischemia-reperfusion both in vivo and in vitro. Brain Res.,24: 104-115.
  • Long, X., Fan, M., Bigsby, R.M., Nephew, K.P. 2008. Apigenin inhibits antiestrogen-resistant breast cancer cell growth through estrogen receptor-A-dependent and estrogen receptor-A-independent mechanisms. Mol. Cancer Ther.,7: 2096-2108.
  • Marcucci, M.C., Ferreres, F., Viguera, C.G., Bankova, V.S., De Castro, S.L., Dantas, A.P., Valente, P.H.M., Paulino, N. 2001. Phenolic compounds from Brazilian propolis with pharmacological activities. J.Ethnopharmacol., 74: 105–112.
  • Márquez, N., Sancho, R., Macho, A., Calzado, M.A., Fiebich, B.L., Muñoz, E. 2004. Caffeic acid phenethyl ester inhibits T-cell activation by targeting both nuclear factor of activated T-cells and NF-kappaB transcription factors. J. Pharmacol. Exp. Ther., 308: 993–1001.
  • Mendonça, I.C.G., Medeiros, M.L.B.B., Penteado, R.A.P.M., Parolia, A., Porto, I.C.C.M. 2013.An overview of the toxic effects and allergic reactions caused by propolis. PharmacologyOnLine, 2: 96-105.
  • Menniti-Ippolito, F, Mazzanti, G, Vitalone A, Firenzuoli, F, Santuccio, C. 2008. Surveillance of suspected adverse reactions to natural health products: the case of propolis. Drug Saf., 31: 419-423.
  • Narayana, K.R., Reddy, M.S., Chaluvadi, M.R., Krishna, D.R. 2001.Bioflavanoids classification, pharmacological, biochemical effects and therapeutic potential.Indian J. Pharmacology, 33: 2-16.
  • Okutan, H., Ozcelik, N., Yilmaz, H.R., Uz, E. 2005. Effects of caffeic acid phenethyl ester on lipid peroxidation and antioxidant enzymes in diabetic rat heart.Clin.Biochem., 38: 191–196.
  • Orsi, R.O., Sforcin, J.M., Funari, S.R.C., Fernandes Jr, A., Bankova, V. 2006. Synergistic effect of propolis and antibiotics on the Salmonella Typhi.Braz. J. Microbiol., 37: 108–112.
  • Pandey, K.B., Rizvi, S.I. 2009.Plant polyphenols as dietary antioxidants in human health and dis-ease.Oxid. Med. Cell Longev.,2:270–278.
  • Paulino, N., Teixeira, C., Martins, R., Scremin, A., Dirsch, V.M., Vollmar, A.M., Abreu, S.R., De Cas-tro, S.L., Marcucci, M.C. 2006.Evaluation of the analgesic and antiinflammatory effects of a Brazilian green propolis.Planta Medica, 72: 899–906.
  • Popova, M., Silici, S., Kaftanoglu, O., Bankova, V. 2005.Antibacterial activity of Turkish propolis and its qualitative and quantitative chemical composition.Phytomedicine, 12: 221–228.
  • Popova, M.P, Bankova, V.S, Bogdanov, S., Tsvetkova, I., Naydenski, C., Marcazzan, L.G., Sabatini, A.G.2007. Chemical characteristics of poplar type propolis of different geographic origin. Apidologie, 38: 306-311.
  • Popova, M., Bankova, V., Chimov, A., Silva, M.V.2002.A scientific note on the high toxicity of propolis that comes from Myroxylon balsamum trees.Apidologie, 33: 87–88.
  • Quiroga, E.N., Sampietro, D.A., Soberon, J.R., Sgariglia, M.A., Vattuone, M.A. 2006. Propolis from the northwest of Argentina as a source of antifungal principles.J. Appl. Microbiol., 101: 103–110.
  • Raina, K., Rajamanickam, S., Deep, G., Singh, M., Agarwal, R., Agarwal, C. 2008. Chemopreventive effects of oral gallic acid feeding on tumor growth and progression in TRAMP mice.Mol. Cancer Ther.,7:1258-1267.
  • Sahinler, N., Kaftanoglu, O. 2005. Natural product propolis: chemical composition. Nat. Prod. Res., 19:183-188.
  • 56) Sarıkaya, A.O. 2009. Kestane bal ve propolisinin fenolik asit kompozisyonu ve antioksidan özelliginin belirlenmesi, (Yüksek lisans tezi), Karadeniz Teknik Üniversitesi, Fen Bilimleri Enstitüsü.
  • Scifo, C., Cardile, V., Russo, A., Consoli, R., Vancheri, C., Capasso, F., Vanella, A., Renis, M. 2004.Resveratrol and propolis as necrosis or apoptosis inducers in human prostate carcinoma cells.Oncol. Res.,14: 415–426.
  • Seidel, V., Peyfoon, E., Watson, D.G., Fearnley, J. 2008. Comperative study of the antibacterial activity of propolis from different geographical and climatic zones. Phytother Research., 22: 1256-1263.
  • Sforcin, J.M.,2007. Propolis and the immune system: a review. J. Ethnopharmacol., 113: 1-14.
  • Silici, S., Kutluca, S. 2005. Chemical composition and antibacterial activity of propolis collected by three different races of honeybees in the same region.J.Ethnopharmacol., 99: 69-73.
  • Silici, S. 2003. Propolisin bazı antimikrobiyal ve farmakolojik aktiviteleri üzerine bir araştırma (Dokto-ra tezi), Çukurova Üniversitesi, Fen Bilimleri Enstitüsü, Zootekni Anabilim Dalı.
  • Silici, S., Koc, A.N. 2006. Comparative study of in vitro methods to analyse the antifungal activity of propolis against yeasts isolated from patients with superficial mycoses. Lett. Appl. Microbiol., 43: 318–324.
  • Sorkun, K., Stler, B., Salih, B. 2001. Determination of chemical composition of Turkish propolis. Zeitschrift für Naturforschung, 56: 666-668.
  • Sova, M.2012.Antioxidant and antimicrobial activities of cinnamic acid derivatives.Mini Rev. Med. Chem., 12: 749-767.
  • Soylu, E.M., Özdemir, A.E., Ertürk, E., Şahinler, N., Soylu, S. 2008.Chemical composition and antifungal activity of propolis against Penicillium digitatum.Asian J. Chem., 20: 4823-4830.
  • Su, Z.Z., Lin, J., Grunberger, D., Fisher, P.B. 1994. Growth suppression and toxicity induced by caf-feic acid phenethyl ester (CAPE) in type-5 adenovirus-transformed rat embryo cells correlate directly with transformation progression. Cancer Res., 54: 1865–1870.
  • Szliszka, E., Czuba, Z.P., Domino, M., Mazur, B., Zydowicz, G., Krol, W. 2009. Ethanolic extract of propolis (EEP) enhances the apoptosis-inducing potential of TRAIL in cancer cells. Molecules, 14: 738-754.
  • Trusheva, B., Trunkova, D., Bankova, V. 2007. Different extraction methods of biologically active components from propolis: a preliminary study.Chem. Cen. J. 7: 1-13.
  • Tsai, S.J., Huang, C.S., Mong, M.C., Kam, W.Y., Huang, H.Y., Yin, M.C. 2012. Anti-inflammatory and antifibrotic effects of naringenin in diabetic mice.J. Agric. Food Chem., 60: 514–521.
  • Ünlü, G.V., Silici, S., Ünlü, M. 2008. Composition and in vitro antimicrobial activity of Populus buds and poplar-type propolis. World J. Microbiol. Biotechnol., 24: 1011–1017.
  • Vafeiadou, K., Vauzour, D., Lee, H.Y., Rodriguez-Mateos, A., Williams, R.J., Spencer, J.P.E. 2009. The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury. Archiv.Biochem.Biophys., 484: 100–109.
  • Velazquez, C., Navarro, M., Acosta, A., Angulo, A., Dominguez, Z., Roble, R., Robles-Zepeda, R., Lugo, E., Goycoolea, F.M., Velazquez, E.F. et al. 2007.Antibacterial and free-radical scavenging ac-tivities of Sonoran propolis.J. Appl. Microbiol., 103: 1747–1756.
  • Velikova, M., Bankova, V., Marcucci, M., Tsvetkova, I., Kujungiev, A. 2000.Chemical Composition and Biological Activity of Propolis from Brazilian Meliponinae.Z. Naturforsch C., 55: 785-789.
  • Wollenweber, E, Hausen, B.M., Greenaway, W. 1990. Phenolic constituents and sensitizing properties of propolis, poplar balsam and balsam of Peru.Bull. Groupe Polyphenols, 15: 112–120.
  • Xiang, D.B., Wang, D., He, Y.J., Xie, J., Zhong, Z.Y., Li, Z.P. 2006. Caffeic acid phenethyl ester in-duces growth arrest and apoptosis of colon cancer cells via the betacatenin ⁄ T-cell factor signaling. Anticancer Drugs, 17: 753–762.
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Journal Section Research Articles
Authors

Hasan Hüseyin Oruç

Publication Date May 29, 2014
Acceptance Date April 15, 2013
Published in Issue Year 2014 Volume: 14 Issue: 1

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Vancouver Oruç HH. Propolisin Sağlık Açısından Önemi, Kalitesinin Belirlenmesi Ve Türkiye Açısından İrdelenmesi. U. Arı. D.-U. Bee J. 2014;14(1):35-43.

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