Trace Element and Lipid Profile in Patients with Type-II Diabetes Mellitus

Year 2020, , 59 - 66, 23.06.2020

Abdullah Arpacı Hasret Ecevit Muhittin Önderci Meral Urhan Küçük Serdar Olt

https://doi.org/10.5455/umj.20200305101734

Abstract

Introduction: This study aimed to investigate the relationship between trace element levels and T2DM in patients from Adıyaman province in southeastern Turkey.
Materials and Methods: This study included 49 healthy subjects and 80 patients diagnosed with T2DM. The study population was divided into healthy controls and patients with T2DM and good glycemic control (GGC) and with T2DM and poor glycemic control (PGC). Biochemical parameters and trace element levels were compared in the three groups.
Results: Fasting blood glucose (FBG) and triglyceride (TG) levels were significantly higher in both diabetic groups and were higher in the PGC than in the GGC group (p<0.05). Low-density lipoprotein cholesterol (LDL-C) and cholesterol (CHO) levels were higher in the PGC than in the control group (p < 0.05). CHO levels were also higher in the PGC than in the GGC group (p<0.05). Elevated manganese (Mn) and chromium (Cr) levels were found in both diabetics, and calcium (Ca) levels were significantly higher in the PGC group than in the controls (p<0.05).
Conclusions: The hyperglycemic and dyslipidemic profiles were significantly elevated in the PGC group compared to the GGC group, suggesting the importance of regular follow-up and treatment in T2DM. The observed positive correlation between T2DM and the levels of the trace elements Mn, Cr, and Ca requires further confirmation in future studies.

Keywords

diabetes mellitus, trace element, glycemic control

References

• Van Belle TL, Coppieters KT, von Herrath MG. Type 1 diabetes: etiology, immunology, and therapeutic strategies. Physiol Rev 2011; 91(1):79-118
• Lin CC, Huang YL. Chromium, zinc and magnesium status in type 1 diabetes. Curr Opin Clin Nutr Metab Care 2015; 18(6):588-92
• Baena-Diez JM, Penafiel J, Subirana I, Ramos R, Elosua R, Marin-Ibanez A, et al. Risk of Cause-Specific Death in Individuals With Diabetes: A Competing Risks Analysis. Diabetes Care 2016; 39(11):1987-95
• Einarson TR, Acs A, Ludwig C, Panton UH. Prevalence of cardiovascular disease in type 2 diabetes: a systematic literature review of scientific evidence from across the world in 2007-2017. Cardiovasc Diabetol 2018; 17(1):83
• Hammes HP, Lemmen KD, Bertram B, German Diabetes A. Diabetic retinopathy and maculopathy. Exp Clin Endocrinol Diabetes 2014; 122(7):387-90
• Waanders F, Visser FW, Gans RO. Current concepts in the management of diabetic nephropathy. Neth J Med 2013; 71(9):448-58
• Abbott CA, Malik RA, van Ross ER, Kulkarni J, Boulton AJ. Prevalence and characteristics of painful diabetic neuropathy in a large community-based diabetic population in the U.K. Diabetes Care 2011; 34(10):2220-4
• Cho NH, Shaw JE, Karuranga S, Huang Y, da Rocha Fernandes JD, Ohlrogge AW, et al. IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract 2018; 138:271-81
• Whiting DR, Guariguata L, Weil C, Shaw J. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract 2011; 94(3):311-21
• Lobo JC, Torres JP, Fouque D, Mafra D. Zinc deficiency in chronic kidney disease: is there a relationship with adipose tissue and atherosclerosis? Biol Trace Elem Res 2010; 135(1-3):16-21
• Yerlikaya FH, Toker A, Aribas A. Serum trace elements in obese women with or without diabetes. Indian J Med Res 2013; 137(2):339-45
• Wolide AD, Zawdie B, Alemayehu T, Tadesse S. Association of trace metal elements with lipid profiles in type 2 diabetes mellitus patients: a cross sectional study. BMC Endocr Disord 2017; 17(1):64
• Praveeena S, Pasula S, Sameera K. Trace elements in diabetes mellitus. J Clin Diagn Res 2013; 7(9):1863-5
• Siddiqui K, Bawazeer N, Joy SS. Variation in macro and trace elements in progression of type 2 diabetes. Scientific World Journal 2014; 2014:461591
• Pittas AG, Lau J, Hu FB, Dawson-Hughes B. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab 2007;92(6):2017-29
• Mertz W. Chromium in human nutrition: a review. J Nutr 1993; 123(4):626-33
• Kazi TG, Afridi HI, Kazi N, Jamali MK, Arain MB, Jalbani N, et al. Copper, chromium, manganese, iron, nickel, and zinc levels in biological samples of diabetes mellitus patients. Biol Trace Elem Res 2008; 122(1):1-18
• Bleys J, Navas-Acien A, Guallar E. Serum selenium and diabetes in U.S. adults. Diabetes Care 2007; 30(4):829-34
• Tang X, Shay NF. Zinc has an insulin-like effect on glucose transport mediated by phosphoinositol-3-kinase and Akt in 3T3-L1 fibroblasts and adipocytes. J Nutr 2001; 131(5):1414-20
• Volpe SL. Magnesium, the metabolic syndrome, insulin resistance, and type 2 diabetes mellitus. Crit Rev Food Sci Nutr 2008; 48(3):293-300
• American Diabetes Association. Standards of medical care in diabetes-2015. Diabetes Care 2015; 38(1):8-16
• Degueldre C, Favarger PY. Thorium colloid analysis by single particle inductively coupled plasma-mass spectrometry. Talanta 2004; 62(5):1051-4
• Degueldre C, Favarger PY, Rosse R, Wold S. Uranium colloid analysis by single particle inductively coupled plasma-mass spectrometry. Talanta 2006; 68(3):623-8
• Zhang H, Yan C, Yang Z, Zhang W, Niu Y, Li X, et al. Alterations of serum trace elements in patients with type 2 diabetes. J Trace Elem Med Biol 2017; 40:91-6
• Mishra S, Mishra BB. Study of Lipid Peroxidation, Nitric Oxide End Product, and Trace Element Status in Type 2 Diabetes Mellitus with and without Complications. Int J Appl Basic Med Res 2017; 7(2):88-93
• Yeasmin R, Muttalib MA, Sultana N, Bhuiyan NH, Alam R. Status of Some Trace Elements in Type-2 Diabetic Patients and its Relationship with Lipid Profile. J. Bangladesh Acad. Sci. 2016; 40(1):79-85
• Ekmekcioglu C, Prohaska C, Pomazal K, Steffan I, Schernthaner G, Marktl W. Concentrations of seven trace elements in different hematological matrices in patients with type 2 diabetes as compared to healthy controls. Biol Trace Elem Res 2001; 79(3):205-19
• Badran M, Morsy R, Soliman H, Elnimr T. Assessment of trace elements levels in patients with Type 2 diabetes using multivariate statistical analysis. J Trace Elem Med Biol 2016; 33:114-9
• Oyedeji SO, Adesina AA, Oke OT, Tijani YO. evaluation of essential trace metals in female type 2 diabetes mellitus patients in Nigerian population 2014; 13(18):1910-14
• Hussain F, Arif Maan M, Sheikh MA, Nawaz H, Jamil A. Trace elements status in type 2 diabetes. Bangladesh Journal of Medical Science 2009; 8(3)
• Masood N, Baloch GH, Ghori RA, Memon IA, Memon MA, Memon MS. Serum zinc and magnesium in type-2 diabetic patients. J Coll Physicians Surg Pak 2009; 19(8):483-6
• Basaki M, Saeb M, Nazifi S, Shamsaei HA. Zinc, copper, iron, and chromium concentrations in young patients with type 2 diabetes mellitus. Biol Trace Elem Res 2012; 148(2):161-4
• Nashiry M, Ishak I, Mohamed J, Budin S, Mohd Fairulnizal MN M, Kamaralzaman S, et al. Evaluation of Trace Elements in Malay Women with Type 2 Diabetes Mellitus. Sains Malaysiana 2019; 48(2):337–45
• Cancarini A, Fostinelli J, Napoli L, Gilberti ME, Apostoli P, Semeraro F. Trace elements and diabetes: Assessment of lels in tears and serum. Exp Eye Res 2017; 154:47-52
• Skalnaya MG, Demidov VA. Hair trace element contents in women with obesity and type 2 diabetes. J Trace Elem Med Biol 2007; 21 Suppl 1:59-61
• Diwan AG, Pradhan AB, Lingojwar D, Krishna KK, Singh P, Almelkar SI. Serum zinc, chromium and magnesium levels in Type 2 diabetes. Int J Diab Dev Ctries 2006 26 (3):122-23
• Ekin S, Mert N, Gunduz H, Meral I. Serum sialic acid levels and selected mineral status in patients with type 2 diabetes mellitus. Biol Trace Elem Res 2003; 94(3):193-201