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Efficacy of Local Lactobacillus Casei Var Rhamnosus Döderlein Monotherapy for Bacterial Vaginosis

Year 2016, Volume: 2 Issue: 1, 20 - 26, 01.01.2016
https://doi.org/10.5455/umj.20160210060327

Abstract

Introduction: The objective of this study was to establish the efficacy of local probiotic monotherapy for the treatment of bacterial vaginosis. Method: A total of 141 women with bacterial vaginosis, randomized into two groups, were examined. In the first group, 85 women were treated with local probiotic medicine QD for 10 days containing Lactobacillus casei var rhamnosus Döderlein Lcr35® . In the second group, 56 patients received the same local probiotic treatment as those in the first group, in addition to treatment with an oral administration of metronidazol 500 mg tablet BID for 7 days . The efficacy of the monotherapeutic scheme was evaluated by comparing the number of clinical complaints and the results of clinical examinations and microbiological tests in the two groups. Results: One month after the probiotic monotherapy in the first group, the clinical efficacy was 47.1% and the microbiological efficacy was 41.1%. The combined treatment in the second group was more efficacious clinical efficacy: 89.3%; microbiological efficacy: 76.7% . Conclusions: Thus, our results indicate that local probiotic monotherapy is less effective than combined metronidazole/probiotic scheme for the treatment of bacterial vaginosis.

References

  • Chimura T, Funayama T, Murayama K, Numazaki M. Ecological treatment of bacterial vaginosis. Jpn J Antibiot ; 48: 432-436. Fredricsson B, Englund K, Weintraub L, Olund A, Nord CE. Bacterial vaginosis is not a simple ecological disorder. Gynecol Obstet Invest 1989; 28:156-160.
  • Hemalatha R, Mastromarino P, Ramalaxmi BA, Balakrishna NV, Sesikeran B. Effectiveness of vaginal tablets containing lactobacilli versus pH tablets on vaginal health and inflammatory cytokines: a randomized, double-blind study. Eur J Clin Microbiol Infect Dis 2012; 31(11):3097-105.
  • Amsel R, Totten PA, Spiegel CA, Chen KCS, Eschenbach D, Holmes KK. Non-specific vaginitis: diagnostic and microbial and epidemiological associations.Am J Med 1983;74:14-22.
  • Nugent RP, Krohn MA, Hillier S. Reliability of diagnosing bacterial vaginosis is improved by standardized method of Gram stain interpretation. J Clin Microbiol 1991;29:297-301.
  • Ison CA, Hay PE. Validation of a simplified grading of Gram stained vaginal smears for use in genitourinary medicine clinics. Sex Transm Infect 2002; 78: 413-415.
  • Hallen A, Jarstrand C, Pahlson C. Treatment of bacterial vaginosis with lactobacilli. Sex Transm Dis 1992;19:146-148.
  • Rossi A, Rossi T, Bertini M, Caccia G. The use of Lactobacillus rhamnosus in the therapy of bacterial vaginosis. Evaluation of clinical efficacy in a population of women treated for 24 months. Arch Gynecol Obstet ; 281(6):1065-9.
  • Mastromarino P, Macchia S, Meggiorini L, Trinchieri V, Mosca L, Perluidgi M, Midulla C. Effectiveness of Lactobacillus-containing vaginal tablets in the treatment of symptomatic bacterial vaginosis. Clin Microbiol Infect 2009; (1): 67-74.
  • Sigridov I, Ivanov S, Batashki I. Preliminary results of Lactofem trial-first impressions. Akush Ginekol (Sofiia) 2007; Suppl 2: 29-32.
  • Eriksson K, Carlsson B, Forsum U, Larsson PG. A double- blind treatment study of bacterial vaginosis with normal vaginal lactobacilli after an open treatment with vaginal clindamycin ovules. Acta Derm Venereol 2005; 85: 42-46.
Year 2016, Volume: 2 Issue: 1, 20 - 26, 01.01.2016
https://doi.org/10.5455/umj.20160210060327

Abstract

References

  • Chimura T, Funayama T, Murayama K, Numazaki M. Ecological treatment of bacterial vaginosis. Jpn J Antibiot ; 48: 432-436. Fredricsson B, Englund K, Weintraub L, Olund A, Nord CE. Bacterial vaginosis is not a simple ecological disorder. Gynecol Obstet Invest 1989; 28:156-160.
  • Hemalatha R, Mastromarino P, Ramalaxmi BA, Balakrishna NV, Sesikeran B. Effectiveness of vaginal tablets containing lactobacilli versus pH tablets on vaginal health and inflammatory cytokines: a randomized, double-blind study. Eur J Clin Microbiol Infect Dis 2012; 31(11):3097-105.
  • Amsel R, Totten PA, Spiegel CA, Chen KCS, Eschenbach D, Holmes KK. Non-specific vaginitis: diagnostic and microbial and epidemiological associations.Am J Med 1983;74:14-22.
  • Nugent RP, Krohn MA, Hillier S. Reliability of diagnosing bacterial vaginosis is improved by standardized method of Gram stain interpretation. J Clin Microbiol 1991;29:297-301.
  • Ison CA, Hay PE. Validation of a simplified grading of Gram stained vaginal smears for use in genitourinary medicine clinics. Sex Transm Infect 2002; 78: 413-415.
  • Hallen A, Jarstrand C, Pahlson C. Treatment of bacterial vaginosis with lactobacilli. Sex Transm Dis 1992;19:146-148.
  • Rossi A, Rossi T, Bertini M, Caccia G. The use of Lactobacillus rhamnosus in the therapy of bacterial vaginosis. Evaluation of clinical efficacy in a population of women treated for 24 months. Arch Gynecol Obstet ; 281(6):1065-9.
  • Mastromarino P, Macchia S, Meggiorini L, Trinchieri V, Mosca L, Perluidgi M, Midulla C. Effectiveness of Lactobacillus-containing vaginal tablets in the treatment of symptomatic bacterial vaginosis. Clin Microbiol Infect 2009; (1): 67-74.
  • Sigridov I, Ivanov S, Batashki I. Preliminary results of Lactofem trial-first impressions. Akush Ginekol (Sofiia) 2007; Suppl 2: 29-32.
  • Eriksson K, Carlsson B, Forsum U, Larsson PG. A double- blind treatment study of bacterial vaginosis with normal vaginal lactobacilli after an open treatment with vaginal clindamycin ovules. Acta Derm Venereol 2005; 85: 42-46.
There are 10 citations in total.

Details

Primary Language English
Journal Section Research Article
Authors

Stefan Kovachev This is me

Rossitza Vatcheva-dobrevska This is me

Publication Date January 1, 2016
Published in Issue Year 2016 Volume: 2 Issue: 1

Cite

Vancouver Kovachev S, Vatcheva-dobrevska R. Efficacy of Local Lactobacillus Casei Var Rhamnosus Döderlein Monotherapy for Bacterial Vaginosis. ULUTAS MED J. 2016;2(1):20-6.