Correlation of Maternal and Cord Blood Leptin Concentrations with Neonatal Birth Weight in Term, Preterm and Growth-Restricted Fetuses

Year 2019, Volume: 5 Issue: 2, 133 - 141, 01.04.2019

Fusun Karbancioglu Canturk

https://doi.org/10.5455/umj.20190220060746

Abstract

Background: To determine the association of cord blood and maternal leptin levels with neonatal birth weight in preterm deliveries, intrauterine growth retarded neonates, and term neonates. Materials and Methods: Sixty parturients were enrolled in this prospective observational study and data of fifty-one parturients were analyzed. There were nine dropouts. Of these patients 20 had intrauterine growth restriction Group I , 15 had moderate preterm labor Group II , and 16 had labor with normal term pregnancies Group III . Obstetric and demographic data were recorded for the mothers and neonates. Cord blood sampling was done just before clamping of the cord and maternal venous blood was sampled within five minutes after parturition. Results: Mean cord blood leptin levels in Groups I, Group II, and Group III were 2.29±2.92, 0.93±0.64, and 2.26±1.78 respectively. Maternal leptin levels in Group I, Group II, and Group III were 8.79±5.92, 4.91±3.76, and 5.83±4.36. Mean birth weights were 2395±461g in Group I, 2142±464 g in Group II, and 3472±419 g in Group III. There was no statistically significant difference in neonatal birth weight between Group I and Group II p=0.487 , whereas the difference was significant for both Group I and Group II compared to Group III p

Keywords

Leptin, intrauterine growth restriction, preterm labor, pregnancy

References

• Beck S, Wojdyla D, Say L, Betran AP, Merialdi M, Requejo JH, et al. The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity. Bull World Health Organ 2010;88:31-8
• Black RE, Cousens S, Johnson HL, Lawn JE, Rudan I, Bassani DG, et al. Global, regional, and national causes of child mortality in 2008: a systematic analysis. Lancet 2010;375: 87
• Liu L, Johnson HL, Cousens S, Perin J, Scott S, Lawn JE, et al. Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet 2012;379:2151-61
• Henson MC, Castracane VD. Leptin in pregnancy: an update. Biol Reprod 2006;74:218-29
• Mantzoros CS, Moschos SJ. Leptin: in search of role(s) in human physiology and pathophysiology. Clin Endocrinol ;49:551-67
• Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-32
• Lepercq J, Guerre-Millo M, Andre J, Cauzac M, Hauguel- de Mouzon S. Leptin: a potential marker of placental insufficiency. Gynecol Obstet Invest 2003;55:151-5
• Linnemann K, Malek A, Sager R, Blum WF, Schneider H, Fusch C. Leptin production and release in the dually in vitro perfused human placenta. J Clin Endocrinol Metab ;85:4298-301
• Bouloumie A, Drexler HC, Lafontan M, Busse R. Leptin, the product of Ob gene, promotes angiogenesis. Circ Res ;83:1059-66
• Mise H, Yura S, Itoh H, Nuamah MA, Takemura M, Sagawa N, et al. The relationship between maternal plasma leptin levels and fetal growth restriction. Endocr J 2007;54:945
• Hauguel-de Mouzon S, Lepercq J, Catalano P. The known and unknown of leptin in pregnancy. Am J Obstet Gynecol ;194:1537-45
• Cetin I, Morpurgo PS, Radaelli T, Taricco E, Cortelazzi D, Bellotti M, et al. Fetal plasma leptin concentrations: relationship with different intrauterine growth patterns from 19 weeks to term. Pediatr Res 2000;48:646-51
• Dotsch J, Nusken KD, Knerr I, Kirschbaum M, Repp R, Rascher W. Leptin and neuropeptide Y gene expression in human placenta: ontogeny and evidence for similarities to hypothalamic regulation. J Clin Endocrinol Metab ;84:2755-8
• Brenner WE, Edelman DA, Hendricks CH. A standard of fetal growth for the United States of America. Am J Obstet Gynecol 1976;126:555-64
• Tamura T, Goldenberg RL, Johnston KE, Cliver SP. Serum leptin concentrations during pregnancy and their relation ship to fetal growth. Obstet Gynecol 1998;91:389-95
• Hinkle SN, Rawal S, Liu D, Chen J, Tsai MY, Zhang C. Maternal adipokines longitudinally measured across pregnancy and their associations with neonatal size, length, and adiposity. Int J Obes 2018 Nov 21
• Pighetti M, Tommaselli GA, D'Elia A, Di Carlo C, Mariano A, Di Carlo A, et al. Maternal serum and umbilical cord blood leptin concentrations with fetal growth restriction. Obstet Gynecol 2003;102:535-43
• Fakor F, Sharami SH, Milani F, Mirblouk F, Kazemi S, Pourmarzi D, et al. The association between level of maternal serum leptin in the third trimester and the occurrence of moderate preterm labor. J Turk Ger Gynecol Assoc 2016;17:182-5
• Shroff MR, Holzman C, Tian Y, Evans RW, Sikorskii A. Mid- pregnancy maternal leptin levels, birthweight for gestational age and preterm delivery. Clin Endocrinol ;78:607-13
• Jaquet D, Leger J, Levy-Marchal C, Oury JF, Czernichow P. Ontogeny of leptin in human fetuses and newborns: effect of intrauterine growth retardation on serum leptin concentrations. J Clin Endocrinol Metab 1998;83:1243-6
• Shekhawat PS, Garland JS, Shivpuri C, Mick GJ, Sasidharan P, Pelz CJ, et al. Neonatal cord blood leptin: its relationship to birth weight, body mass index, maternal diabetes, and steroids. Pediatr Res 1998;43:338-43
• Takahashi Y, Yokoyama Y, Kawabata I, Iwasa S, Tamaya T. Leptin as an acute stress-related hormone in the fetoplacental circulation. Obstet Gynecol 2002;100:655-8
• Harigaya A, Nagashima K, Nako Y, Morikawa A. Relationship between concentration of serum leptin and fetal growth. J Clin Endocrinol Metab 1997;82:3281-4
• Matsuda J, Yokota I, Iida M, Murakami T, Naito E, Ito M, et al. Serum leptin concentration in cord blood: relationship to birth weight and gender. J Clin Endocrinol Metab ;82:1642-4
• Chen H, Xu L, Zhu W, Wu Y, Xu M, Wang Z. Impact of Cord Blood Adiponectin and Leptin Levels and Maternal Obesity on Birth Weight of Infants Born to Women with Gestational Diabetes Mellitus. J Reprod Med. 2017;62(3- ):179-83
• Clapp JF, 3rd, Kiess W. Cord blood leptin reflects fetal fat mass. J Soc Gynecol Investig 1998;5:300-3
• Yoshimitsu N, Douchi T, Kamio M, Nagata Y. Differences in umbilical venous and arterial leptin levels by mode of delivery. Obstet Gynecol 2000;96:342-5
• Kayemba-Kay's S, Geary MP, Pringle J, Rodeck CH, Kingdom JC, Hindmarsh PC. Gender, smoking during pregnancy and gestational age influence cord leptin concentrations in newborn infants. Eur J Endocrinol ;159:217-24
• Pardo IM, Geloneze B, Tambascia MA, Barros-Filho AA. Does maternal smoking influence leptin levels in term, appropriate-for-gestational-age newborns? J Matern Fetal Neonatal Med 2004;15:408-10