Abstract
Background: Scleredema diabeticorum is a dermatosis characterized by hardening of skin over the upper back. It is commonly seen in poor-controlled diabetic patients. Therapeutic options are limited. Psoralen and ultraviolet A therapy PUVA , methotrexate, and topical steroids have been used with some success. Pentoxifylline is a xanthine derivative used mainly in peripheral vascular diseases. It also has antifibrotic effects due to its collagen synthesis inhibition action. Case Presentation: In this paper, a trial of intralesional pentoxifylline treatment and magnetic resonance images of a male patient with scleredema diabeticorum are presented. Some subjective symptoms of the patient improved after this treatment, but, the thickness of the lesion did not change. Conclusion: Pentoxifylline, probably via the oral route, could still be thought in such patients unresponsive to conventional approaches due to its antifibrotic activity and high safety profile.
Keywords
References
- 1.Menteş Miguel D, Schliemann S, Elsner P. Treatment of Scleroedema Adultorum Buschke: A systematic review. Acta Derm Venereol 2018;98:305-309
- 2.Jung SE, Kim YC. Scleredema of Buschke following streptococcal infection. Ann Dermatol 2015;27(4):478-80
- 3.Ng E, Rosenstein R, Terushkin V, Meehan S, Pomeranz MK. Idiopathic scleredema. Dermatol Online J 2016;22(12)
- 4.Lemes LR, Vilela GM, Durães SM, Vilar EA. Scleredema of Buschke associated with difficult-to-control type 2 diabetes mellitus. Rev Assoc Med Bras 2016;62:199-201
- 5.Kreuter A. Scleredema adultorum: Clinical presentation, diagnostic workup, differential diagnosis, treatment option. Hautarzt 2018;11:908-915
- 6.Sadaksharam J, Mahalingam S. Evaluation of Pentoxifylline in the management of oral submucous fibrosis - An ultrasonographic study. Contemp Clin Dent 2017;8:200-204
- 7.Alam S, Nazmul Hasan S, Mustafa G, Alam M, Kamal M, Ahmad N. Effect of Pentoxifylline on histological activity and fibrosis of nonalcoholic steatohepatitis patients: A one year randomized control trial. J Transl Int Med 2017;5(3):155-163
- 8.Plotnikov MB, Shamanaev AY, Aliev OI, Sidekhmenova AV, Anishchenko AM, Arkhipov AM. Pentoxifylline treatment enhances antihypertensive activity of captopril through hemorheologicalimprovement in spontaneously hypertensive rats during development of arterial hypertension. J Am Soc Hypertens 2017;11:769-778
Abstract
References
- 1.Menteş Miguel D, Schliemann S, Elsner P. Treatment of Scleroedema Adultorum Buschke: A systematic review. Acta Derm Venereol 2018;98:305-309
- 2.Jung SE, Kim YC. Scleredema of Buschke following streptococcal infection. Ann Dermatol 2015;27(4):478-80
- 3.Ng E, Rosenstein R, Terushkin V, Meehan S, Pomeranz MK. Idiopathic scleredema. Dermatol Online J 2016;22(12)
- 4.Lemes LR, Vilela GM, Durães SM, Vilar EA. Scleredema of Buschke associated with difficult-to-control type 2 diabetes mellitus. Rev Assoc Med Bras 2016;62:199-201
- 5.Kreuter A. Scleredema adultorum: Clinical presentation, diagnostic workup, differential diagnosis, treatment option. Hautarzt 2018;11:908-915
- 6.Sadaksharam J, Mahalingam S. Evaluation of Pentoxifylline in the management of oral submucous fibrosis - An ultrasonographic study. Contemp Clin Dent 2017;8:200-204
- 7.Alam S, Nazmul Hasan S, Mustafa G, Alam M, Kamal M, Ahmad N. Effect of Pentoxifylline on histological activity and fibrosis of nonalcoholic steatohepatitis patients: A one year randomized control trial. J Transl Int Med 2017;5(3):155-163
- 8.Plotnikov MB, Shamanaev AY, Aliev OI, Sidekhmenova AV, Anishchenko AM, Arkhipov AM. Pentoxifylline treatment enhances antihypertensive activity of captopril through hemorheologicalimprovement in spontaneously hypertensive rats during development of arterial hypertension. J Am Soc Hypertens 2017;11:769-778
Details
| Primary Language | English |
|---|---|
| Journal Section | Case Report |
| Authors | |
| Publication Date | July 1, 2019 |
| Published in Issue | Year 2019 Volume: 5 Issue: 3 |