Evaluation of Plasma Selenium, Zinc and Malondialdehyde Levels in Newly Diagnosed Preeclamptic Women at A Teaching Hospital

Year 2021, Volume: 7 Issue: 2, 89 - 91, 25.06.2020

Obianuju Ilechukwu

https://doi.org/10.5455/umj.20210422011242

Abstract

Introduction: Preeclampsia is a clinical condition unique to humans which forms a major part of hypertensive disorders in pregnancy. Although its exact etiology remains unknown, an imbalance between lipid peroxides and antioxidants is implicated. The study aimed to evaluate plasma selenium, zinc, and malondialdehyde (MDA) levels in newly diagnosed preeclamptic women attending antenatal visits at Chukwuemeka Odumegwu Ojukwu University Teaching Hospital (COOUTH), Awka in Anambra State.
Materials and Methods: A total of 81 female participants were recruited and grouped into three (A, B, and C) comprising 21 newly diagnosed preeclamptic women, 30 healthy pregnant control, and 30 non-pregnant control participants respectively.
Results: The newly diagnosed preeclamptics had significantly lower plasma selenium levels when compared with the healthy pregnant and non-pregnant controls (p<0.05). The plasma zinc level in the preeclamptics did not differ significantly from the level in healthy pregnant women (p>0.05), it was however significantly lower in the preeclamptics and healthy pregnant women when compared with the non-pregnant women (p<0.05). Plasma MDA level was significantly elevated in the preeclamptics compared to the healthy pregnant and non-pregnant control participants (p<0.05).
Conclusion: Newly diagnosed preeclamptics have lower plasma selenium and zinc levels with higher plasma MDA levels, and additional sources of these micronutrients may be required.

Keywords

Preeclampsia, Pregnancy, Selenium, Zinc, Malondialdehyde

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