Bir Türk Popülasyonunda Preeklampsi ACE Gen Promoter Bölgesinin Rolü

Year 2022, Volume: 1 Issue: 1, 34 - 42, 18.08.2022

Ergün Pınarbaşı Beyza Duran Aslıhan Esra Bildirici Şeyda Akın Nilgün Çekin

Abstract

Keywords

ACE2, preeklampsi, varyasyon

The Role of The ACE Gene Promoter Region in Preeclampsia in a Turkish Population

Abstract

It is known that preeclampsia (PE), a common multisystemic and multifactorial pregnancy disease, causes 10-15% of direct maternal deaths worldwide. Many research, including whole genome sequencing studies, has been and continues to be done in search of a mutant gene that can cause the disease. According to studies, one of the candidate genes associated with PE is ACE2 gene. Therefore, in this study, it was aimed to investigate the variations in the promoter region of ACE2 gene for the first time in a Turkish population. Sequencing analysis was performed on genetic material obtained from maternal blood with samples collected from 60 PE patients and 60 healthy pregnant women with demographic data compatible with the patients. Sequencing analysis was performed with the Sanger sequencing method and ABI 3130XL instrument. According to the results of the sequence analysis, no variation was found in the studied region. However, PE disease remains a major health problem in pregnancy, and accumulating evidence indicates that ACE2 may also have effects on the disease. Therefore, improved structural and functional studies in larger populations are needed to understand these effects.

Keywords

ACE2, preeclampsia, variation

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