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The effect of genetic factors on sportive performance

Year 2015, Volume: 1 Issue: 1, 63 - 76, 04.01.2016
https://doi.org/10.18826/ijsets.65225

Abstract

Sportive performance may be describe as all of the efforts put forth to succeed during fulfilling an obligatory athletic duty. One of the most important factors that affect sportive performance is genetic differences. Among these, mutations, polymorphism, epigenetic factors and chimerism lead. Mutations are permanent changes in genetic build and seen less than 1% of population. On the other hand, polymorphisms are seen more than 1% of population and are the existence of two or more different phenotype in the same kind of population. Epigenetic factors in which there is no change in DNA chain, while at the same time, it can change gene activation. However, chimerism is a single organism that is composed of two or more different populations of genetically distinct cells that originated from different zygotes involved in pregnancy. As a conclusion, it is found out that sportive performance may change due to the individuals’ phenotype feature changes caused by differences in genetic substructure.

References

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Genetik faktörlerin sportif performansa etkisi

Year 2015, Volume: 1 Issue: 1, 63 - 76, 04.01.2016
https://doi.org/10.18826/ijsets.65225

Abstract

Sportif performans, atletik görev sırasında başarı için ortaya konulan çabalardır. Performansı etkileyen en önemli faktörlerden birisi genetik farklılıklardır. Bunlar arasında mutasyonlar, polimorfizmler, epigenetik faktörler ve kimerizm başta gelir. Mutasyonlar, kalıtsal yapıda meydana gelen ve toplumun % 1’inden daha az oranda görülen kalıcı değişimlerdir. Polimorfizmler ise toplumun % 1’inden daha yüksek oranda görülen ve iki veya daha fazla farklı fenotipin aynı tür popülasyonunda bulunmasıdır. Epigenetik faktörler, DNA dizisinde değişiklik meydana gelmeden, aynı zamanda kalıtımsal olan ve gen aktivasyonunu değiştiren etmenlerdir. Kimerizm ise birden fazla DNA’ya sahip olan yani ana rahminde iki döllenmiş yumurtanın, gebeliğin ilerleyen zamanlarında birleşmesiyle ikiz yerine tek canlı üremesidir. Sonuç olarak genetik farklılıkların kişilerin fenotipik özelliklerini değiştirmesiyle sportif performansın değişebileceği ortaya çıkmıştır.

References

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  • De la Chapelle. A., Traskelin, A.L., Juvonen, E. (1993). Truncated erythropoietin receptor causes dominantly inherited benign human erythrocytosis. Proc Natl Acad Sci U S A, 90(10):4495-9.
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  • Egger, G., Liang, G., Aparicio, A. and Jones, P.A. (2004). Epigenetics in human disease and prospects for epigenetic therapy. Nature, (429):457–463.
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  • Girgenrath, S., Song, K., Whittemore, L.A. (2005). Loss of myostatin expression alters fiber-type distribution and expression of myosin heavy chain isoforms in slow- and fast-type skeletal muscle. Muscle Nerve. 31: 34–40.
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  • Gunel, T., Gumusoglu, E., Hosseini, M.K., Yilmazyildirim, E., Dolekcap, I., Aydinli, K. (2014). Effect of angiotensin I-converting enzyme and α-actinin-3 gene polymorphisms on sport performance. Mol Med Rep., 9(4):1422-6.
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  • Hautala, A.J., Rankinen, T., Kiviniemi, A.M., et al. (2006). Heart rate recovery after maximal exercise is associated with acetylcholine receptor M2 (CHRM2) gene polymorphism. Am J Physiol Heart Circ Physiol., 291:H459-H466.
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  • Henderson, J., Withford-Cave, J.M., Duffy, D.L., et al. (2005). The EPAS1 gene influences the aerobic-anaerobic contribution in elite endurance athletes. Hum Genet., 118:416-423.
  • Heyn, H., Li, N., Ferreira, H.J., et al. (2012). Distinct DNA methylomes of newborns and centenarians. Proc Natl Acad Sci USA., 109: 10522–7.
  • Hillman, C.H., Erickson, K.I., Kramer, A.F. (2008). Be smart, exercise your heart: exercise effects on brain and cognition. Nat Rev Neurosci., 9:58–65.
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  • Lucia, A., Gomez-Gallego, F., Barroso, I., Rabadan, M., Bandres, F., San Juan, A.F., Chicharro, J.L., Ekelund, U., Brage, S., Earnest, C.P., Wareham NJ & Franks PW (2005). PPARGC1A genotype (Gly482Ser) predicts exceptional endurance capacity in European men. J Appl Physiol, 99: 344–348.
  • Marcell, T.J., Hawkins, S.A., Tarpenning, K.M., ve ark. (2003). Longitudinal analysis of lactate threshold in male and female master athletes. Med Sci Sports Exerc.,35(5):810-7.
  • Mason, S.D., Rundqvist, H., Papandreou, I., et al. (2007). HIF-1alpha in endurance training: suppression of oxidative metabolism. Am J Physiol Regul Integr Comp Physiol, 293:R2059-R2069.
  • McGee, S.L., Fairlie, E., Garnham, A.P., et al. (2009). Exercise-induced histone modifications in human skeletal muscle. J Physiol., 587: 5951–8.
  • McPherron, A.C., Lawler, A.M., Lee, S.J. (1997). Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature, 387:83–90.
  • Mokone, G.G., Gajjar, M., September, A.V., et al. (2005). The guanine-thymine dinucleotide repeat polymorphism within the tenascin-C gene is associated with Achilles tendon injuries. Am J Sports Med., 33:1016-1021.
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There are 86 citations in total.

Details

Primary Language Turkish
Subjects Sports Medicine
Journal Section SPORT & HEALTH SCIENCES
Authors

Onur Eroğlu

Raif Zileli

Publication Date January 4, 2016
Submission Date September 30, 2015
Published in Issue Year 2015 Volume: 1 Issue: 1

Cite

APA Eroğlu, O., & Zileli, R. (2016). Genetik faktörlerin sportif performansa etkisi. International Journal of Sport Exercise and Training Sciences - IJSETS, 1(1), 63-76. https://doi.org/10.18826/ijsets.65225