Kinetics of cytokines IL-6, IL-10 and TNF-α and their relationship with serum IGF-I and IGFBP-3 concentrations in adolescent swimmers throughout a training season

Year 2020, Volume: 6 Issue: 4, 138 - 148, 15.12.2020

Marcela Pires , Hugo Tourinho Filho , Eike Bianchi Kohama , Rafael Fornel , Rodrigo José Custodio , Carlos Martinelli Jr

https://doi.org/10.18826/useeabd.843434

Cited By: 1

Abstract

Aim: The objective of this study was to analyze the kinetics of the IL-6, IL-10, and TNF-α cytokines and their relationship with the serum IGF-I and IGFBP-3 levels of adolescent swimmers throughout a training season.

Methods: Nine male adolescent swimmers aged 16 to 19 years old, classified in stages 4-5 for pubic hair growth on the Tanner scale, were recruited as the study sample. All the procedures took place in the early phase (extensive phase), intermediate phase (intensive phase), and final phase (tapering) of the athletes’ season. At the beginning of each stage, the athletes were evaluated as follows: an anthropometric evaluation and blood samples were taken before and after a standardized training session (STS).

Results: It was possible to verify a strong and inversely proportional relationship between serum levels of IL-6 and IGF-I during the most intensive phase of training and an increase in serum concentrations of IGF-I and IL-10 during the tapering phase. Regarding the acute effects of training it was possible to identify differentiated kinetics only for the IGF-I values during the intensive phase and for the IL-10 values during the tapering phase.

Conclusion: IGF-I, IGFBP-3, and IL-10 concentrations proved sensitive to both the acute or chronic effects of exercise. Thus, it can be suggested that these components may be used as important markers of the training condition of adolescent swimmers during their preparation throughout a season.

Keywords

Biomarkers, GH/IGF-I axis, Cytokines, Swimming, Adolescents

Supporting Institution

School of Physical Education and Sport of Ribeirao Preto, University of São Paulo, Ribeirao Preto, Brazil

Thanks

Dr. Ibrahim Erdemir, PhD and Dr. Gul Tirvaki-Sonmez PhD Editors-in-Chief – International Journal of Sport, Exercise and Training Science Dear Dr. Ibrahim Erdemir, and Dr. Gul Tirvaki-Sonmez I am writing in order to submit the paper entitled “Kinetics of cytokines IL-6, IL-10, and TNF-α and their relationship with serum IGF-I and IGFBP-3 concentrations in adolescent swimmers” to be considered for publication in the International Journal of Sport, Exercise and Training Science. This manuscript represents results of original work that have not been published elsewhere (except as an abstract in conference proceedings). This manuscript has not and will not be submitted for publication elsewhere until a decision is made regarding its acceptability for publication in International Journal of Sport, Exercise and Training Science. If accepted for publication, it will not be published elsewhere. This research is not part of a larger study. We would like to inform that there are no conflicts of interest regarding our study. We also would like to stat that; 1) all authors agree with the content of the article and approve its submission to this journal; 2) All authors acknowledge ethical responsibility for the content of the manuscript and will accept the consequences of any ethical violation; 3) the experiments reported in the article were undertaken in compliance with the current laws of the country in which the experiments were performed. Authors will be held responsible for false statements. Thank you very much for your attention. I am looking forward to hearing from you. Yours sincerely, Hugo Tourinho Filho School of Physical Education and Sport of Ribeirao Preto University of São Paulo 14.040-907, Ribeirao Preto, SP, Brazil

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