THE PHYLOGENETIC RELATIONSHIPS OF LIPASE ENZYMES ACCORDING TO THEIR THERMAL STABILITY BY A COMPUTATIONAL APPROACH

Abstract

Molecular Phylogenetic Analysis studies conducted to reveal the evolutionary relationships of biological sequences, use two basic methodologies. In the study of distance-based methodologies, phylogenetic trees were obtained by clustering Lipase enzymes according to their thermal stability. The biological sequences to be used in the study were obtained from the NCBI Genbank database. Methods were coded in the Java programming language and distance matrices were obtained.  Phylogenetic trees were constructed using the R language. As a result, Lipase enzymes were effectively clustered using a distance-based method without alignment, according to their thermal stability.

Keywords

• Molecular Phylogeny,distance based methodology,enzyme clustering

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