Research Article
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Year 2019, Volume: 2 Issue: 1, 22 - 38, 30.06.2019

Abstract

References

  • 1. Brar HS, Keselowsky BG, Sarntinoranont M and Manuel MV. Design considerations for developing biodegradable and bioabsorbable magnesium implants. JOM-US 2011; 63, 100–4.
  • 2. Chen YJ, Li YJ, Walmsley JC, Dumoulin S, Skaret PC and Roven HJ. Microstructure evolution of commercial pure titanium during equal channel angular pressing. Mater SciEng A: Struct 2010; 527, 789–96.
  • 3. Chen Y, Xu Z, Smith C and Sankar J. Recent advances on the development of magnesium alloys for biodegradable implants. ActaBiomaterialia 2014; 10, 4561-73.
  • 4. Erinc M, Sillekens WH, Mannens R and Werkhoven RJ. Applicability of existing magnesium alloys as biomedical implant materials. Warrendale, PA: Minerals, Metals and Materials Scociety 2009; p, 209–14.
  • 5. Kokubo T and Takadama H. How useful is SBF in predicting in vivo bone bioactivity?. Biomaterials 2006; 27, 2907–2915.
  • 6. Nakamura Y, Tsumura Y, Tonogai Y, Shibata T and Ito Y. Differences in behavior among the chlorides of seven rare earth elements administered intravenously to rats. FundamApplToxicol 1997; 37, 106–16.
  • 7. Poinern GEJ, Brundavanam S and Fawcett D. Biomedical magnesium alloys: a review of material properties, surface modifications and potential as a biodegradable orthopaedic implant. Am J Biomed Eng 2012; 2, 218–40.
  • 8. Peng QM, Huang YD, Zhou L, Hort N and Kainer KU. Preparation and properties of high purity Mg–Y biomaterials. Biomaterials 2010; 31, 398–403.
  • 9. Persaud-Sharma D and McGoron A. Biodegradable magnesium alloys: a review of material development and applications. J BiomimeticsBiomater Tissue Eng 2011; 12, 25–39.
  • 10. Polmear IJ. Grades and alloys. In: Avedesian MM, Baker H, editors. Magnesium and magnesium alloys. Materials Park, OH: ASM International Handbook Committee 1999; p, 12–25.
  • 11. Staiger MP, Pietak AM, Huadmai J and Dias G. Magnesium and its alloys as orthopedic biomaterials: a review. Biomaterials 2006; 27: 1728–34.
  • 12. Wen CE, Yamada Y, Shimojima K, Chino Y, Hosokawa H and Mabuchi M. Compressibility of porous magnesium foam: dependency on porosity and pore size. Mater Lett 2004;58: 357–60.
  • 13. Witte F, Feyerabend F, Maier P, Fischer J, Stormer M and Blawert C. Biodegradable magnesium–hydroxyapatite metal matrix composites. Biomaterials 2007; 28: 2163–74.
  • 14. Witte F, Hort N, Vogt C, Cohen S, Kainer KU and Willumeit R. Degradable biomaterials based on magnesium corrosion. CurrOpin Solid State Mater 2008; 12, 63–72.
  • 15. Xu ZG, Smith C, Chen SO and Sankar J. Development and microstructural characterizations of Mg–Zn–Ca alloys for biomedical applications. Mater SciEng B: Adv 2011; 176, 1660–5.
  • 16. Yang Z, Li JP, Zhang JX, Lorimer GW and Robson J. Review on research and development of magnesium alloys. ActaMetall Sin (English Lett) 2008; 21, 313–28.
  • 17. Zberg B, Uggowitzer PJ and Loffler JF. MgZnCa glasses without clinically observable hydrogen evolution for biodegradable implants. Nat Mater 2009; 8, 887-91.

Mg/Zn COMPOSITES PRODUCED BY MECHANICAL ALLOYING AND HOT PRESSING AND IN-VITRO BIODEGRADATION

Year 2019, Volume: 2 Issue: 1, 22 - 38, 30.06.2019

Abstract

Biodegradable
implants have many advantages over conventional steel and titanium based
implants. Most important one of these advantages is the ability of these
implants to degrade within a desired span of time (compatible with tissue and
bone growth) after their function is over, without giving any harm to the body.
The aim of this study is to develop a magnesium based biodegradable implant to
be used as a bone plate. Mechanical and physical properties of Mg alloys that
should possess for these applications are almost completely established,
whereas the applicability still has to be investigated. In this study, Mg/MgZn/Zn composites were produced by mechanical alloying
and hot pressing.
Biodegradability of Mg/MgZn/Zn composites was tested
as in-vitro in simulated body fluid (SBF) solution. SBF is nearly equal to
human body blood plasma with ion concentrations. Seven implants were produced.
They were placed in SBF solution and then their corrosion resistances were
followed.
During the process, visual changes of the implants
were observed, pH, Mg ion concentrations of SBF solutions and mass, dimensional
changes of degraded implants in solutions were measured. As soon as, implants
were placed in SBF solutions, gas outlet of H
2 was observed, because
of Redox reaction, which took place between implants and SBF.
The composites in SBF
remained between 1-360 hours and Zn% 2.35 and 3.10 had the longest degradation
time when compared to others. Therefore, only three of the composites Zn% 0 (7h),
2.35 (360h) and 3.10 (192h) were selected for further, SEM and mechanical
control tests.

References

  • 1. Brar HS, Keselowsky BG, Sarntinoranont M and Manuel MV. Design considerations for developing biodegradable and bioabsorbable magnesium implants. JOM-US 2011; 63, 100–4.
  • 2. Chen YJ, Li YJ, Walmsley JC, Dumoulin S, Skaret PC and Roven HJ. Microstructure evolution of commercial pure titanium during equal channel angular pressing. Mater SciEng A: Struct 2010; 527, 789–96.
  • 3. Chen Y, Xu Z, Smith C and Sankar J. Recent advances on the development of magnesium alloys for biodegradable implants. ActaBiomaterialia 2014; 10, 4561-73.
  • 4. Erinc M, Sillekens WH, Mannens R and Werkhoven RJ. Applicability of existing magnesium alloys as biomedical implant materials. Warrendale, PA: Minerals, Metals and Materials Scociety 2009; p, 209–14.
  • 5. Kokubo T and Takadama H. How useful is SBF in predicting in vivo bone bioactivity?. Biomaterials 2006; 27, 2907–2915.
  • 6. Nakamura Y, Tsumura Y, Tonogai Y, Shibata T and Ito Y. Differences in behavior among the chlorides of seven rare earth elements administered intravenously to rats. FundamApplToxicol 1997; 37, 106–16.
  • 7. Poinern GEJ, Brundavanam S and Fawcett D. Biomedical magnesium alloys: a review of material properties, surface modifications and potential as a biodegradable orthopaedic implant. Am J Biomed Eng 2012; 2, 218–40.
  • 8. Peng QM, Huang YD, Zhou L, Hort N and Kainer KU. Preparation and properties of high purity Mg–Y biomaterials. Biomaterials 2010; 31, 398–403.
  • 9. Persaud-Sharma D and McGoron A. Biodegradable magnesium alloys: a review of material development and applications. J BiomimeticsBiomater Tissue Eng 2011; 12, 25–39.
  • 10. Polmear IJ. Grades and alloys. In: Avedesian MM, Baker H, editors. Magnesium and magnesium alloys. Materials Park, OH: ASM International Handbook Committee 1999; p, 12–25.
  • 11. Staiger MP, Pietak AM, Huadmai J and Dias G. Magnesium and its alloys as orthopedic biomaterials: a review. Biomaterials 2006; 27: 1728–34.
  • 12. Wen CE, Yamada Y, Shimojima K, Chino Y, Hosokawa H and Mabuchi M. Compressibility of porous magnesium foam: dependency on porosity and pore size. Mater Lett 2004;58: 357–60.
  • 13. Witte F, Feyerabend F, Maier P, Fischer J, Stormer M and Blawert C. Biodegradable magnesium–hydroxyapatite metal matrix composites. Biomaterials 2007; 28: 2163–74.
  • 14. Witte F, Hort N, Vogt C, Cohen S, Kainer KU and Willumeit R. Degradable biomaterials based on magnesium corrosion. CurrOpin Solid State Mater 2008; 12, 63–72.
  • 15. Xu ZG, Smith C, Chen SO and Sankar J. Development and microstructural characterizations of Mg–Zn–Ca alloys for biomedical applications. Mater SciEng B: Adv 2011; 176, 1660–5.
  • 16. Yang Z, Li JP, Zhang JX, Lorimer GW and Robson J. Review on research and development of magnesium alloys. ActaMetall Sin (English Lett) 2008; 21, 313–28.
  • 17. Zberg B, Uggowitzer PJ and Loffler JF. MgZnCa glasses without clinically observable hydrogen evolution for biodegradable implants. Nat Mater 2009; 8, 887-91.
There are 17 citations in total.

Details

Primary Language English
Journal Section Articles
Authors

Simay Erdibil 0000-0002-8687-5312

Serap Cesur This is me 0000-0001-6581-0854

Rasim İpek

Publication Date June 30, 2019
Submission Date October 18, 2018
Acceptance Date May 2, 2019
Published in Issue Year 2019 Volume: 2 Issue: 1

Cite

APA Erdibil, S., Cesur, S., & İpek, R. (2019). Mg/Zn COMPOSITES PRODUCED BY MECHANICAL ALLOYING AND HOT PRESSING AND IN-VITRO BIODEGRADATION. Usak University Journal of Engineering Sciences, 2(1), 22-38.
AMA Erdibil S, Cesur S, İpek R. Mg/Zn COMPOSITES PRODUCED BY MECHANICAL ALLOYING AND HOT PRESSING AND IN-VITRO BIODEGRADATION. UUJES. June 2019;2(1):22-38.
Chicago Erdibil, Simay, Serap Cesur, and Rasim İpek. “Mg/Zn COMPOSITES PRODUCED BY MECHANICAL ALLOYING AND HOT PRESSING AND IN-VITRO BIODEGRADATION”. Usak University Journal of Engineering Sciences 2, no. 1 (June 2019): 22-38.
EndNote Erdibil S, Cesur S, İpek R (June 1, 2019) Mg/Zn COMPOSITES PRODUCED BY MECHANICAL ALLOYING AND HOT PRESSING AND IN-VITRO BIODEGRADATION. Usak University Journal of Engineering Sciences 2 1 22–38.
IEEE S. Erdibil, S. Cesur, and R. İpek, “Mg/Zn COMPOSITES PRODUCED BY MECHANICAL ALLOYING AND HOT PRESSING AND IN-VITRO BIODEGRADATION”, UUJES, vol. 2, no. 1, pp. 22–38, 2019.
ISNAD Erdibil, Simay et al. “Mg/Zn COMPOSITES PRODUCED BY MECHANICAL ALLOYING AND HOT PRESSING AND IN-VITRO BIODEGRADATION”. Usak University Journal of Engineering Sciences 2/1 (June 2019), 22-38.
JAMA Erdibil S, Cesur S, İpek R. Mg/Zn COMPOSITES PRODUCED BY MECHANICAL ALLOYING AND HOT PRESSING AND IN-VITRO BIODEGRADATION. UUJES. 2019;2:22–38.
MLA Erdibil, Simay et al. “Mg/Zn COMPOSITES PRODUCED BY MECHANICAL ALLOYING AND HOT PRESSING AND IN-VITRO BIODEGRADATION”. Usak University Journal of Engineering Sciences, vol. 2, no. 1, 2019, pp. 22-38.
Vancouver Erdibil S, Cesur S, İpek R. Mg/Zn COMPOSITES PRODUCED BY MECHANICAL ALLOYING AND HOT PRESSING AND IN-VITRO BIODEGRADATION. UUJES. 2019;2(1):22-38.

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