Veteriner cerrahide lokal kök hücre uygulamaları

Year 2023, , 30 - 37, 30.04.2023

Tuba Özge Yaşar , Cem Perk

https://doi.org/10.31797/vetbio.1248347

Abstract

Kök hücreler; organizmada organların ve dokuların yapısını oluşturan ana hücrelerdir. Bu sebeple ihtiyaç halinde hasar gören tüm doku ve organlara dönüşüm sağlayarak bunların onarılmasında ciddi rol almaktadır. İnsan hekimliğinde son 10 yılda yaygın bir kullanım alanı bulan kök hücre tedavisi, günümüzde veteriner tıbbında da uygulanmaktadır. Mezenkimal kök hücreler hayvanlarda pek çok hastalığın tedavisinde kullanılmaktadır. Steril ortamlarda kemik iliği, kordon kanı, ve yağ dokudan elde edildikten sonra sıvı azot tanklarında dondurularak saklanmaktadır. Hastaya uygulama öncesinde enjeksiyona hazır hale getirilerek taze olarak verilmektedir. Kök hücreler, hayvanlara lokal enjeksiyon ya da intra venöz yolla uygulanmaktadır. Viral ve enfeksiyöz hastalıklarda canlıda immun sistemin güçlendirilmesi amacıyla intravenöz yolla mezenkimal kök hücreler kullanılmaktadır. Çeşitli ortopedik, nörolojik ve oftalmolojik hastalıkların tedavisinde ise kök hücreler lokal olarak uygulanmaktadır. Sunulan bu çalışmada, 8 köpek, 6 kedi üzerinde toplam 14 vakaya ait veriler yer almaktadır. 7 ortopedik, 5 nörolojik, 2 oftalmolojik vakada lokal yolla uygulanan mezenkimal kök hücre tedavisi ve elde edilen sonuçlar değerlendirilmiştir. Ortopedik ve nörolojik vakalarda büyük oranda iyileşme sağlandığı, oftalmolojik olgularda da belirgin düzelmeler olduğu saptanmıştır.

Keywords

Keratit, kornea ülseri, kök hücre, nonunion, nöropati, osteoatritis

In Veterinary surgery local stem cell applications

Abstract

Stem cells; they are the main cells that form the structure of organs and tissues in the organism. For this reason, it takes a serious role in repairing all tissues and organs that are damaged when needed. Stem cell therapy, which has found widespread use in human medicine in the last 10 years, is also applied in veterinary medicine today. Mesenchymal stem cells are used in the treatment of many diseases in animals. It is obtained from bone marrow, cord blood, and adipose tissue in sterile environments and stored in liquid nitrogen tanks by freezing. It is given to the patient freshly by making it ready for injection before administration. Stem cells are administered to animals by local injection or intravenous route. In order to strengthen the immune system in vivo in viral and infectious diseases, intravenous mesenchymal stem cells are used. Stem cells are applied locally in the treatment of various orthopedic, neurological and ophthalmological diseases. In this presented study, data of 14 cases on 8 dogs and 6 cats are included. Locally applied mesenchymal stem cell therapy in 7 orthopedic, 5 neurological and 2 ophthalmologic cases and the results obtained were evaluated. It was determined that a great improvement was achieved in orthopedic and neurological cases, and significant improvements were also observed in ophthalmological cases.

Keywords

corneal ulcer, keratitis, neuropaty, nonunion, osteoarthritis, stem cells

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