Effects of increasing doses of enrofloxacin on biochemical parameters in ducks

Year 2024, , 217 - 223, 27.12.2024

Duygu Durna Çorum , Devran Coşkun , Feray Altan , Zafer Bulut , Orhan Çorum

https://doi.org/10.31797/vetbio.1503966

Abstract

This research aims to determine the effect of oral single-dose administration of 10, 50, and 100 mg/kg of enrofloxacin on ducks on biochemical parameters. The research was carried out on eighteen ducks. Ducks were divided into 3 equal groups to receive 10, 50, and 100 mg/kg doses. Blood samples were taken at 0, 6, 12, 24 and 48 hours. No clinical side effects were observed in ducks after enrofloxacin administration. When dose groups were compared, significant differences were observed in aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), albumin (ALB), cholesterol (CHOL), total protein (TP) and creatinine (CRE) values (p<0.05). However, these differences returned to normal at the 48 hour. When the dose groups were evaluated within themselves, ALT, GGT, CHOL, triglyceride, and urea values did not differ (p>0.05). However, there were significant differences in AST, ALP, ALB, and CRE values at 10 mg/kg, AST at 50 mg/kg, and TP at 100 mg/kg (p<0.05). In conclusion, it was determined that oral administration of enrofloxacin to ducks at doses of 10, 50, and 100 mg/kg caused temporary changes in biochemical parameters. In this study, enrofloxacin was administered as a single dose. However, considering the repeated use of enrofloxacin in case of bacterial infection, attention should be paid to possible adverse effects that may occur in ducks.

Keywords

Ascending dose, biochemical, duck, enrofloxacin

Ethical Statement

The experiment was approved (2022/06-03) by the Local Ethics Committee for Animal Research Studies at Hatay Mustafa Kemal University (Hatay/Turkiye) and carried out by the European Directive (2010/63/EU).

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