Comparison of impact of synchronization protocols applied to ewes on pregnancy rate in Turkey with bayesian meta-analysis

Year 2021, , 106 - 115, 31.08.2021

Burak Mat , Murat Polat , Zeynep Özel Mert Demirsöz

https://doi.org/10.31797/vetbio.908999

Abstract

The present study carried a meta-analysis of the pregnancy rates of different synchronization protocols implemented in ewes in Turkey. A common pregnancy rate was estimated by coalescing pregnancy rates, and the heterogeneity between the studies was explored. All studies were carried out independently. This article compiled 28 studies that determined the pregnancy rate for 2,437 ewes in the synchronization studies between the years 1995–2020. The overall effect size of the meta-analysis was found to be 0.66 (95% confidence interval; 0.58–0.74) (p<0.001). This meta-analysis indicates that fertility parameters were improved with the highest effect size in the synchronization protocol used in ewes during the breeding season by combining various doses of PMSG at the end of intravaginal sponge application as a source of progesterone. In terms of subgroups, 40 mg FGA + 300 IU PMSG (95% confidence interval; 0.50–0.61), 40 mg FGA + 500 IU PMSG (95% confidence interval; 0.44–0.52), and 40 mg FGA + 700 IU PMSG (95% confidence interval; 0.41–0.61) protocol effect size was estimated to be higher than other protocols during the season. Thus, it is possible to control the reproductive performance in enterprises with estrus synchronization protocols and mating of ewes. However, it is important to validate which of these methods are optimum in terms of economy and efficiency in enterprise conditions. Considering the effects of synchronization protocols on pregnancy, it is predicted that Bayes meta-analysis will guide enterprises as a decision support system in achieving optimum pregnancy rates.

Keywords

ewes, meta-analysis, pregnancy rate, synchronization, Turkey

References

• Referans1 Akbaş, Ö. F. (2016). The effect of different synchronization programs on some reproductive parameters during breeding season in awassi ewes. Mustafa Kemal University Graduate School of Health Sciences, MSc Thesis, Hatay-Turkey.
• Referans2 Aköz, M., Bülbül, B., Bozkurt A. M., & Dere, S. (2006). Induction of multiple births in Akkaraman cross-bred sheep synchronized with short duration and different doses of progesterone treatment combined with PMSG outside the breeding season. Bulletin-Veterinary Institute in Pulawy, 50(1), 97–100.
• Referans3 Aköz, M., Bodu M., &Acibaeva B. (2015). Current Methods in estrus synchronization pf ewes and does. Turkiye Klinikleri J Reprod Artif Insemin-Special Topics, 1(2), 1-8.
• Referans4 Algan, M. N. (2014). The effects of fluorogeston acetate and eCG on some reproductive parameters in lactating Pirlak sheep. Afyon Kocatepe University Graduate School of Health Sciences, MSc Thesis, Afyonkarahisar-Turkey.
• Referans5 Arıkan M. S. (2021). Koyun ve Keçi Hekimliği. In: Yarsan, E. (Ed.), İşletme Ekonomisi, Chapter 21, pp.821-822,. ISBN 9789752778238
• Referans6 Ataman, M. B., Aköz, M., Fındık, M., & Saban, E. (2009). Induction of synchronized oestrus in Akkaraman cross-bred ewes treated with prostaglandine F2 alpha, norgestomet and sponges impregnated with different doses of fluorogestene acetate at the beginning transitional period. Kafkas Univ Vet Fak Derg, 15(5), 801–805.
• Referans7 Baştan, A., & Küpülü, Ş. (1995). The effects of melatonin and progestagen on reproductive performance in Akkaraman ewes. Ankara Univ Vet Fak Derg., 4(2), 263–270.
• Referans8 Bisinotto, R. S., Lean, I. J., Thatcher, W. W., & Santos, J. E. P. (2015). Meta-analysis of progesterone supplementation during timed artificial insemination programs in dairy cows. J Dairy Sci, 98(4), 2472–2487. doi: https://doi.org/10.3168/jds.2014-8954
• Referans 9Bolstad, W. M. (2007). Introduction to Bayesian Statistics, Wiley-Interscience, UK.
• Referans 10 Borchardt, S., Haimerl, P., Pohl, A., & Heuwieser, W. (2017). Evaluation of prostaglandin F2α versus prostaglandin F2α plus gonadotropin-releasing hormone as Presynch methods preceding an Ovsynch in lactating dairy cows: A meta-analysis. J Dairy Sci, 100(5), 4065–4077. doi: 10.3168/jds.2016-11956
• Referans 11 Borchardt, S., Pohl, A., Carvalho, P. D., Fricke, P. M., & Heuwieser, W. (2018). Short communication: effect of adding a second prostaglandin F2a injection during the Ovsynch protocol on luteal regression and fertility in lactating dairy cows: a meta-analysis. J Dairy Sci, 101, 1–6. doi: 10.3168/jds.2017-14191
• Referans12 Crosby, T. F., Boland, M. P., & Gordon, I. (1991). Effect of progestagen treatments on the incidence of oestrus and pregnancy rates in ewes. Animal reproduction science, 24(1–2), 109–118. doi: https://doi.org/10.1016/0378-4320(91)90086-F
• Referans13 Dogan, I., & Nur, Z. (2006). Different estrous induction methods during the non-breeding season in Kivircik ewes. Veterinarni Medicina, 51(4), 133–138. doi: 10.17221/5532-VETMED.
• Referans14 Doğanay, M. (2011). The impact of different dosage usage of progestagen+PMSG on the stimulation of ovarian activity, synchronication of sexual cycles and subsequent fertility rate of merino ewes during the anoestros season. Ankara University Graduate School of Health Sciences, MSc Thesis, Ankara-Turkey.
• Referans15 Doğruer, G., Ergun, Y., Karaca, F., Sarıbay, M. K., Ateş, C. T., Aköz, M., & Aydin, I. (2015). The effect of applications of eCG and PGF2α at different times with FGA containing vaginal sponges on reproductive parameters in ewes at anestrous season. Eurasian J Vet Sci, 2015, 31, 3, 158–162. doi: 10.15312/EurasianJVetSci.2015310973
• Referans16 Duval, S., & Tweedie, R. (2000). Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics, 56(2), 455–63. doi: 10.1111/j.0006-341x.2000.00455.x
• Referans17 Duymaz, Y. (2020). The effect of different synchronization methods on fertility in kivircik sheep in anoestrus period. Bursa Uludag University Graduate School of Natural and Applied Sciences, MSc Thesis, Bursa-Turkey.
• Referans18 Emrelli, A., Horoz, H., & Tek, Ç. (2003). The effect of melatonin and progestagen treatments on stimulation of oestrus cycle and reproductive patterns in Merino ewes out of the breeding season. J Fac Med Vet Istanbul University, 29(2), 267–275.
• Referans19 Esen, F., & Bozkurt, T. (2001). Effect of flushing and oestrus synchronization application on fertility in Akkaraman sheep. Turkish J. Vet. Anim. Sci., 25(3), 365–368.
• Referans20 Kacar, C., Kamiloglu, N. N., Gurbulak, K., Pancarci, S. M., Gungor, O., Guevenc, K., & Saban, E. (2008). The effect of administration of testosterone antibody, beta-Carotene and vitamin E on multiple pregnancy and MDA (Malondialdehyde) in Tuj breed sheep in non-breeding season. Kafkas Univ Vet Fak Derg, 14(1), 51–56.
• Referans21 Karakaya, S. (2019). The use of darkness apllication in the out-season heat synchronization in akkaram sheep. Kırşehir Ahi Evran University Graduate School of Natural and Applied Sciences, MSc Thesis, Kırşehir-Turkey.
• Referans22 Kaya, H. H., Kaşıkçı, G., Ak, K., Alkan, S., & Sönmez, C. (2003). Controlling the breeding season using melatonin and progestagen in kıvırcık ewes. Turkish J. Vet. Anim. Sci., 27(2), 301–305.
• Referans23 Kaya, R. (2019). Effects of melatonin and melatonin + progesterone on estrus synchronization and fertility parameters in tuj sheep outside of the breeding season. Kafkas University Graduate School of Health Sciences, MSc Thesis, Kars-Turkey.
• Referans24 Kaya, S., Kaçar, C., Kaya, D., & Aslan, S. (2013). The effectiveness of supplemental administration of progesterone with GnRH, hCG and PGF2α on the fertility of Tuj sheep during the non-breeding season. Small ruminant research, 113(2–3), 365–370. doi: https://doi.org/10.1016/j.smallrumres.2013.03.018
• Referans25 Koyuncu, M., Uzun, Ş. K., & Şengül, L. (2001). Synchronization of oestrus and the possibilities of improving reproductive performance by using progestagen and different doses of PMSG in Kıvırcık Ewes. Turkish J. Vet. Anim. Sci., 25(6), 971–974.
• Referans26 Köse, M., Kırbaș, M., Bülbül, B., Dursun, Ș., & Demİrci, U. (2016). Investigation of possibility of increasing lamb production with Flushing plus Ram effect or the administration of various pregnant mare serum gonadotropin doses in Akkaraman ewes. Atatürk Üniversity Journal of Veterinary Sciences., 11(1), 54–59.
• Referans27 Kulaksız, R., Dașkın, A., & Dalcı, T. (2011). Some reproductive traits of ewes from different breeds following oestrus synchronisation by Flugeston Acetate-eCG during the breeding season. Atatürk Üniversity Journal of Veterinary Sciences., 6(1), 9–15.
• Referans28 Kuru, M., Sogukpinar, O., Makav, M., & Cetin, N. (2017). Effect of barium selenate injections on fertility of Pirlak ewes subjected to estrus synchronization during non-breeding season. Med Weter, 73(8), 479–482. doi: 10.21521/mw.5758
• Referans29 Lipsey, M. W., & Wilson, D. B. (2001). Practical meta-analysis. SAGE publications, Inc.
• Referans30 Ocak, A. 2007. Oestrus synchronization by short term administrations in chios strain cross ewes in the breeding season. Selçuk University Graduate School of Health Sciences, PhD Thesis, Konya-Turkey.
• Referans31 Ozyurtlu, N., Kucukaslan, I., & Cetin, Y. (2010). Characterization of oestrous induction response, oestrous duration, fecundity and fertility in Awassi ewes during the non-breeding season utilizing both CIDR and intravaginal sponge treatments. Reprod. Domest. Anim., 45(3), 464–467. doi: 10.1111/j.1439-0531.2008.01246.x
• Referans32 Özbilek, İ. (2019). The effect of sexual syncronization by reduced dose PGF2α on some reproductive parameters in sheep. Mustafa Kemal University Graduate School of Health Sciences, MSc Thesis, Hatay-Turkey.
• Referans33 Öztürkler, Y., Çolak, A., Baykal, A., & Güven, B. (2003). Combined effect of a prostaglandin analogue and a progestagen treatment for five days on oestrus synchronisation in Tushin ewes. Indian Vet. J, 80, 917–920.
• Referans34 Palacin, I., Miranda, F. F., & Martínez, J. A. A. (2011). Meta-analysis of the efficacy of melatonin implants for improving reproductive performance in sheep. Span. J. Agric. Res., (3), 730–743. doi: 10.5424/sjar/20110903-348-10
• Referans35 Patsopoulous, N., Evangelou, E., & Ioannidis, J. P. A. (2008). Sensitivity of between-study heterogeneity in meta-analysis: proposed metrics and empirical evaluation. Int J Epidemiol, 37(5): 1148–1157. doi: 10.1093/ije/dyn065
• Referans36 Rabiee, A. R., Lean, I. J., & Stevenson, M. A. (2005). Efficacy of Ovsynch program on reproductive performance in dairy cattle: A meta-analysis. Journal of Dairy Science, 88(8), 2754–2770. doi: 10.3168/jds.S0022-0302(05)72955-6
• Referans37 Solak, M. (2009). The effect of timed artificial insemination (in out of breeding season) on pregnancy rates in ovulation and oestrus synchronization protocols appled akkaraman breed ewes. Erciyes University Graduate School of Health Sciences, MSc Thesis, Kayseri-Turkey.
• Referans38 Sutton, A. J., Abrams, K. R., & Jones, D. R. (2001). An illustrated guide to the methods of meta-analysis. J Eval Clin Pract, 7(2), 135–148. doi: 10.1046/j.1365-2753.2001.00281.x
• Referans39 Timurkan, H., & Yildiz, H. (2005). Synchronization of oestrus in Hamdani ewes: The use of different PMSG doses. Bulletin-Veterinary Institute in Pulawy, 49(3), 311–314.