Relationship among Some Colostral Immune Parameters and Hepcidin in Neonatal Calves

Year 2019, Volume: 4 Issue: 2, 51 - 58, 31.08.2019

Ekin Emre Erkılıç , Hidayet Metin Erdoğan

https://doi.org/10.31797/vetbio.538251

Cited By: 1

Abstract

This study was designed to determine hepcidin, IgG,
Lactoferrin, IL-6 and iron levels in blood serum, colostrum, milk of healthy
cows and the healthy calves on different days of the neonatal period. The study
included 20 pregnant cows and 20 calves born to them. Blood samples were taken
from pregnant animals 15 days before the birth and immediately after the birth
for measurements. Blood samples were also obtained from the calves at birth
before colostrum intake and 1, 3, 7, 14 and 28 days after birth for
measurements. Colostrum samples were collected from mothers immediately after
birth and milk samples were taken postpartum on days 1, 3 and 7. After
parturition, serum hepcidin levels were higher than pregnant cows (P>0.05).
Hepcidin levels in colostrum were found significantly higher (P<0.05) when
compared with milk samples Following the intake of colostrum, serum hepcidin
level of calves of day 1 was similar to that of day 3 (P>0.05) but
significantly higher than the values of day 7, 14 and 28 days of life in calves
(P<0.001). Serum hepcidin levels similar pattern of changes to those of IgG,
Lf and IL-6 after colostrum intake in calves.

As a result; It was concluded that hepcidin may be an
important component in terms of calf health, given that it shows similar
changes with the immune parameters.

Keywords

Hepcidin, immune parameters, neonatal calves

References

• Abel Francisco, S.F., Quigley, J.D. (1993). Serum immunglobulin concentrations after feeding maternal colostrum or maternal colostrum plus colostral supplement to dairy calves. Am J Vet Res, 54(7), 1051-1054.
• Actor, J.K., Hwang, S.A., Kruzel, M.L. (2009). Lactoferrin as a natural immune modulator. Curr Pharm Des, 15(17), 1956-1973.
• Anderson, G.J., Darshan, D., Wilkins, S.J., Frazer, D.M. (2007). Regulation of systemic iron homeostasis: how the body responds to changes in iron demand. Biometals, 20, 665-674.
• Barton, M.H., Hurley, D., Norton, N., Heusner, G., Costa, L., Jones, S., Byars, D., Watanabe, K. (2006). Serum lactoferrin and immonoglobulin G concentration in healthy or ill neonatal foals and heathy adult horses. J Vet Intern Med, 20, 1457-1462. Blum, J.W., Hammon, H. (2000). Colostrum effects on the gastrointestinal tract, and on nutritional, endocrine and metabolic parameters in neonatal calves. Livest Prod Sci, 66, 151-159.
• Dao, M.C., Sen, S., Iyer, C., Klebenov, D., Meydani, S.N. (2013). Obesity during pregnancy and fetal iron status: is Hepcidin the link?. J Perinatol, 33(3), 177-181.
• Dawes, M.E., Latrikz, J., Tyler, J.W., Cockrell, M., Marsh, A.E., Estes, D.M., Larson, R.L., Steevens, B. (2004). Effects of supplemental lactoferrin on serum lactoferrin and IgG concentrations and neutrophil oxidative metabolism in Holstein calves. J Vet Intern Med, 18, 104-108.
• Detilleux, J.C., Kehrli, M.E., Stabel, J.R., Freeman, A.E., Kelley, D.H. (1995). Study of immunological dysfunction in periparturient holstein cattle selected for high and avarage milk production. Vet Immunol Immunopathol, 44, 251-267.
• Dewell, R.D., Hungerford, L.L., Keen, J.E., Laegreid, W.W., Griffin, D.D., Rupp, G.P., Grotelueschen, D.M. (2006). Association of neonatal serum immunoglobulin G1 concentration with health and performance in beef calves. J Am Vet Med Assoc, 228(6), 914-921.
• Erdoğan, H.M., Ünver, A., Citil, M., Güneş, V., Arslan, M.Ö., Tuzcu, M., Gökce, H.İ. (2009). Dairy farming in Kars district, Turkey: III. Neonatal calf health. Turk J Vet Anim Sci, 33(3), 185-192.
• Ergönül, S., Kontaş Askar, T. (2009). Anaplasmosisli sığırlarda ısı şok protein (HSP), malondialdehit (MDA), nitrik oksit (NO) ve interleukin (IL-6, IL-10) düzeylerinin araştırılması. Kafkas Univ Vet Fak Derg, 15(4), 575-579.
• Finkenstedt, A., Widschwendter, A., Brasse-Lagnel, C.G., Theurl, I., Hubalek, M., Dieplinger, H., Tselepis, C., Ward, D.G., Vogel, W., Zoller, H. (2012). Hepcidin is correlated to soluble hemojuvelin but not to increased GDF15 during pregnancy. Blood Cells Mol Dis, 48(4), 233-237.
• Foley, J.A., Otterby, D.E. (1978). Availability, storage, treatment, composition and feeding value of surplus colostrum: A Review. J Dairy Sci, 61, 1033-1060.
• Franklin, S.T., Newman, M.C., Newman, K.E., Meek, K.I. (2005). Immune parameter of dry cows fed mannan oligosaccharide and subsequent transfer of immunity to calves. J Dairy Sci, 88, 766-775.
• Ganz, T. (2003). Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood, 102(3), 783-788.
• Ganz, T., Nemeth, E. (2012). Hepcidin and iron homeostasis. Biochim Biophys Acta, 1823, 1434-1443.
• Gilbert, R.P., Gaskins, C.T., Hillers, J.K., Parker, C.F., McGuire, T.C. (1988). Genetic and environmental factors affecting immunoglobulin G1 concentrations in ewe colostrum and lamb serum. J Anim Sci, 66(4), 855-863.
• Godden, S. (2008). Colostrum management for dairy calves. Vet Clin North Am Food Anim Pract, 24(1), 19-39.
• Godson, D.L., Acres, S.D., Haines, D.M. (2003). Failure of passive transfer and effective colostrum management in calves. Large Anim Vet Rounds, 3(10), 1-6.
• Gomes, V., Madureira, K.M., Soriano, S., Melville, A.M., Libera, P.D., Blagitz, M.G., Benesi, F.J. (2011). Factors affecting immunglobulin concentration in colostrum of healty holstein cows immediately after delivery. Pesq Vet Bras, 31(Supl 1), 53-56.
• Gökçe, E., Erdoğan, H.M. (2013). Neonatal buzağılarda kolostral immunglobulinlerin pasif transferi. Türkiye Klinikleri J Vet Sci, 4(1), 18-46.
• Gökçe, E., Atakisi, O., Kirmizigul, A.H., Unver, A., Erdoğan, H.M. (2014). Passive immunity in lambs: Serum lactoferrin concentrations as a predictor of IgG concentration and its relation to health status from birth to 12 weeks of life. Small Ruminant Res, 116, 219-228.
• Hagiwara, K., Kataoka, S., Yamanka, H., Kirisawa, R., Iwai, H. (2000). Detection of cytokines in bovine colostrum. Vet Immunol Immunopathol, 76, 183-190.
• Herr, M., Bostedt, H., Failing, K. (2011). IgG and IgM levels in dairy cows during the periparturient period. Theriogenology, 75, 377-385.
• Hidalgo, M.A., Loncomán, C.A., Hidalgo, A.I., Andrade, V., Carretta, M.D., Burgos R,A. (2014). Decreased cyclooxygenase-2 gene expression and lactoferrin release in blood neutrophils of heifers during the calving period. Vet Immunol Immunopathol, 160(1-2), 139-144.
• Holloway, N.M., Latrikz, J., Tyler, J.W., Carlson, S.L. (2002). Serum lactoferrin concentrations in colostrum-fed calves. Am J Vet Res, 63, 476-478.
• Klinkon, M., Ježek, J. (2012). Values of Blood Variables in Calves. In: Perez-Marin CC (Ed), A Bird's-Eye View of Veterinary Medicine. 1st ed. InTech, 301-320, Croatia. Ulaşım adresi: http://www.intechopen.com/books/a-bird-s-eye-view-of-veterinary-medicine/values-ofblood-variables-in-calves. Erişim Tarihi: 10.12.2014.
• Koening, M.D., Tussing-Humphreys, L., Day, J., Cadwell, B., Nemeth, E. (2014). Hepcidin and iron homeostasis during pregnancy. Nutrients, 6(8), 3062-3083.
• Kume, S.I., Tanabe, S. (1993). Effect of parity on colostral mineral concentrations of Holstein cows and value of colostrum as a mineral source for newborn calves. J Dairy Sci, 76(6), 1654-1660.
• Lönnerdal, B., Keen, C.L., Hurley, L.S. (1981). Iron, copper, zinc, and manganese in milk. Ann Rev Nutr, 1, 149-174.
• Nemeth, E., Tuttle, M.S., Powelson, J., Vaughn, M.B., Donovan, A., Ward, D.M., Ganz, T., Kaplan, J. (2004). Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science, 306(5704), 2090-2093.
• Noaman, V., Rasti, M., Ranjbari, A.R., Shirvani, E. (2012). Serum copper, zinc and iron status of various bovine categories on Holstein dairy cattle farms. Comp Clin Pathol, 21(6), 1727-1731.
• Noaman, V. (2014). Serum copper, zinc and iron concentrations of Holstein dairy cows in different seasonal and physioligical states. Comp Clin Pathol, 23, 1059-1062. Ong, S.T., Ho, J.Z.S., Ho, B., Ding, J.L. (2006). Iron-withholding strategy in innate immunity. Immunobiology, 211(4), 295-314.
• Orro, T., Jacobsen, S., Lepage, J.P., Niewold, T., Alasuutari, S., Soveri, T. (2008). Temporal changes in serum concentration of acute phase proteins in newborn dairy calves. Vet J, 176(2), 182-187.
• Pakkanen, R., Aalto, J. (1997). Growth factors and antimicrobial factors of bovine colostrum. Int Dairy J, 7(5), 285-297.
• Rocha, T.G., Nociti, R.P., Sampaio, A.A.M., Fagliari, J.J. (2012). Passive immunity transfer and serum constituents of crossbred calves. Pesq Vet Bras, 32(6), 515-522.
• Sanchez, L., Aranda, P., Perez, M.D., Calvo, M. (1988). Concentration of lactoferrin and transferrin throughout lactation in cow's colostrum and milk. Biol Chem Hoppe Seyler, 369, 1005-1008.
• Sheldon, I.M., Dobson, H. (2004). Postpartum uterine health in cattle. Anim Reprod Sci, 82-83, 295-306.
• Singh, B., Arora, S., Agrawal, P., Gupta, S.K. (2011). Hepcidin: a novel peptide hormone regulating iron metabolism. Clin Chim Acta, 412(11-12), 823-830.
• Sobczuk-Szul, M., Wielgosz-Groth, Z., Wronsky, M., Rzemıenıewski, A. (2013). Changes in the bioactive protein concentration in the bovine colostrum of Jersey and Polish Hostein-Friesian cows. Turk J Vet Anim Sci, 37, 43-49.
• Talukder, J.R., Takeuchi, T., Harada, E. (2003). Receptor-mediated transport of lactoferrin into the cerebrospinal fluid via plasma in young calves. J Vet Med Sci, 65(9), 957-964.
• Tyler, J.W., Parish, S.M., Besser, T.E., Van Metre, D.C., Barrington, G.M., Middleton, J.R. (1999). Detection of low serum immunoglobulin concentrations in clinically ill calves. J Vet Intern Med, 13(1), 40-43.
• Van Santen, S., Kroot, J.J.C., Zijderveld, G., Wiegerinck, E.T., Spaanderman, M.E.A., Swinkels, D.W. (2013). The iron regulatory hormone hepcidin is decreased in pregnancy: a prospective longitudinal study. Clin Chem Lab Med, 51(7), 1395-1401.
• Vyoral, D., Petrak, J. (2005). Hepcidin: A direct link between iron metabolism and immunity. Int J Biochem Cell Biol, 37(9), 1768-1773.
• Yamanaka, H., Hagiwara, K., Kirisawa, R., Iwai, H. (2003). Transient detection of proinflammatory cytokines in sera of colostrum-fed newborn calves. J Vet Med Sci, 65(7), 813-816.
• Yokuş, B., Çakır, U.D. (2006). Seasonal and physiological variations in serum chemistry and mineral concentrations in cattle. Biol Trace Elem Res, 109(3), 255-266.