Efficacy of intravenous phenylbutazone for pain management in dogs undergoing ovariohysterectomy

Year 2019, Volume: 4 Issue: 3, 112 - 118, 30.12.2019

Murat Kibar

https://doi.org/10.31797/vetbio.599784

Abstract

The aim of the
present study was to evaluate the efficacy and analgesic duration of single
dose of PBZ administered the IV route immediately before induction of
anesthesia in dogs undergoing elective OVH. Eight-teeen sexually intact female
dogs (weiging between 4.5 and 28 kg, and 1 to 8 yrs of age) referred for OVH procedure from a local shelter at regular intervals over 4
months were included in the study. The dogs were administered PBZ on the basis
of their respective treatment group (20 mg/kg, IV administration) immediately
before anesthetic induction. For the IV treatment, PBZ was administered over a
period of one minute. Time of completion of PBZ administration was designed as
time 0. In control group, 0.9% NaCl was administered IV as over a period of one
minute. Throughout the study, pre and postoperative pain was assessed at
baseline (before induction of anesthesia) and then at 0.5, 1, 2, 3, 8, and 24
hrs after the surgery. Group IV had significantly lower CMPS-SF scores than the control group at
the 0.5, 1, 2, 3, and 8 hour postoperative periods. In conclusion, a single
dose of PBZ administered via the IV route before surgery may be particularly
beneficial for acheiving reasonable perioperative analgesia, but not in
postoperative period. 

Keywords

Ovariyohisterektomi, Ağrı, Fenilbutazon

Supporting Institution

-

Project Number

-

Thanks

-

References

• Carpenter, S.L., Mcdonnell, W.M. (1995). Misuse of veterinary phenylbutazone. Arch Intern Med, 155: 1229–1231.
• Grandemange, E., Fournel, S., Woehrlé, F. (2013). Efficacy and safety of cimicoxib in the control of perioperative pain in dogs. J Small Anim Pract, 54: 304–312.
• Gruet, P., Seewald, W., King, N.J. (2013). Robenacoxib versus meloxicam for the management of pain and inflammation associated with soft tissue surgery in dogs: a randomized, non-inferiority clinical trial. BMC Vet Res, 9: 92.
• Hunt, J.R., Grint, N.J., Taylor, P.M., et al. (2013). Sedative and analgesic effects of buprenorphine, combined with either acepromazine or dexmedetomidine, for premedication prior to elective surgery in cats and dogs. Vet Anaesth Analg, 40: 297-307.
• Ko, J.C., Freeman, L.J., Barletta, M., et al. (2011). Efficacy of oral transmucosal and intravenous administration of buprenorphine before surgery for postoperative analgesia in dogs undergoing ovariohysterectomy. J Am Vet Med Assoc, 238: 318–328.
• Lees, P., Landoni, M.F., Giraudel, J., et al. (2004). Pharmacodynamics and pharmacokinetics of nonsteroidal anti-inflammatory drugs in species of veterinary interest. J Vet Pharm Therap, 27: 479–490.
• Marcovich, R., Williams, A.L., Seifman, B.D., et al. (2001). A canine model to assess the biochemical stress response to laparoscopic and open surgery. J Endourol, 15: 1005-1008.
• Mbugua, S.W., Skoglund, L.A., Løkken, P. (1989). Effects of phenylbutazone and indomethacin on the post-operative course following experimental orthopaedic surgery in dogs. Acta Vet Scand, 30: 27-35.
• Mills, P.C., Ng, J.C., Skelton, K.V., et al. (1995). Phenylbutazone in racing greyhounds: plasma and urinary residues 24 and 48 hours after a single intravenous administration. Aust Vet J, 72: 304-8.
• Ortega, M. and Cruz, I. (2011). Evaluation of a constant rate infusion of lidocaine for balanced anesthesia in dogs undergoing surgery. Can Vet J, 52: 856-860.
• Pacheco, P.F., Galeazzi, V.S., Patrício, G.C.F., et al. (2018). Anesthetic complications in diabetic dogs subjected to phacoemulsification. Pesq Vet Bras, 38: 1423-1430.
• Peers, A., Mellor, D.J., Wintour, E.M., et al. (2002). Blood pressure, heart rate, hormonal and other acute responses to rubber-ring castration and tail docking of lambs. N Z Vet J, 50: 56-62.
• Reid, J., Nolan, A.M., Hughes, J.M.L., et al. (2007). Development of the short-form Glasgow Composite Measure Pain Scale (CMPS-SF) and derivation of an analgesic intervention score. Anim Welf, 16: 97-104.
• Thurman, J.C., Tanquilli, W.J., Benson, G.J. (1996). Preanesthetics and anesthetic adjuncts. In: Thurmon JC, Tranquilli WC, Benson GJ eds. Lumb and Jones Veterinary Anesthesia. 3rd ed. Philadelphia: Williams and Wilkins, 183-203.
• Williamson, H.E., Gaffney, G.R., Bourland, W.A., et al. (1978). Phenylbutazone-induced decrease in renal blood flow. J Pharmacol Exp Ther, 204: 130-134.
• Zech, R., Scherkl, R., Hashem, A., Frey, H.H. (1993). Plasma and tissue kinetics of phenylbutazone and naproxen in dogs. Arch Int Pharmacodyn Ther, 325: 113-128.