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Cerebellar hypoplasia in an Azawakh dog: A case report

Year 2020, Volume 5, Issue 1, 20 - 26, 30.04.2020
https://doi.org/10.31797/vetbio.622632

Abstract

In this case report, the nine-month-old male Azawakh dog  was observed to ataxia, uncoordinated move­ments, difficulties in walking and standing, intensive head tremors, trouble evacuating and eating. It was determined mild cerebellar hypoplasia at the magnetic resonance imaging. Symptomatic treatment was started with glu­cocorticoids, vitamin B1, B6and diazepam. But these drugs had no effect on symptoms and the dog died after three weeks. It described a macroscopic cerebellar reduction in the necropsy and cerebellum and granular cell hypoplasia in histopathologically. Immunohistochemically, the atrophy of neuronal cells showing positive staining with anti-GFAP antibody and vacuolar degeneration were identified.

Based on clinical findings, MR imaging, histopathological and immunochemical findings, cerebellar hypoplasia was diagnosed in the dog and this study is the first case detected in the Azawakh dog.

References

  • 1. Appel, M.J., Shek, W.R., Summers, B.A. (1982). Lymphocytemediated İmmune Cytotoxicity İn Dogs İnfected With Virulent Canine Distemper Virus. Infect. Immun, 37(2), 592- 600.
  • 2. Bernardıno, F., Rentmeıster, K., Schmıdt, M.J., Bruehschweın, A., Matıasek, K., Matıasek, L.A., Lauda, A., Schoon, H.A., Fischer, A. (2015). Inferior Cerebellar Hypoplasia Resembling a Dandy-Walker-Like Malformation in Purebred Eurasier Dogs with Familial Non-Progressive Ataxia: A Retrospective and Prospective Clinical Cohort Study. Plos One, 10(2).
  • 3. Choı, H., Kang, S.Y., Jeong, S., Cho, S., Lee, K., Eom, K., Lee, H., Chang, D., Yoon, J., Lee, Y. (2007). Imaging diagnosis-cerebellar vermis hypoplasia in a Miniature Schnauzer. Vet. Radiol. Ultrasound, 48(2), 129-131.
  • 4. Chrısman, C., Marıanı, C., Platt, S., Clemmons, R. (2003). Neurology for the Small Animal Practitioner. USA: Teton NewMedia. 204-205.
  • 5. De Lahunta, A. (1990). Abiotrophy in domestic animals: a review. Can J Vet Res, 54(1), 65-76.
  • 6. Flegel, T., Matıasek, K., Henke, D., Grevel, V. (2007). Cerebellar cortical degeneration with selective granule cell loss in Bavarian mountain dogs. J Small Anim Pract, 48(8), 462-465.
  • 7. Johnson, K.P., Ferguson, L.C., Byıngton, D.P., Redman, D.R. (1974). Multiple fetal malformations due to persistent viral infection. I. Abortion, intrauterine death, and gross abnormalities in fetal swine infected with hog cholera vaccine virus. Lab. Invest, 30(5), 608–617.
  • 8. Lım, J.H., Kım, D.Y., Yoon, J., Kım, W.H., Kweon, O. (2008). Cerebellar vermian hypoplasia in a Cocker Spaniel. J. Vet. Sci, 9(2), 215-217.
  • 9. Mackıllop, E. (2011). Magnetic resonance imaging of intracranial malformations in dogs and cats. Vet Radiol Ultrasound, 52(1), 42-51.
  • 10. March, P. (1996). Degenerative brain disease. In: Bagley R (ed’s), Intracranial Disease, Vet Clinics of North America. WB Saunders, Philadelphia, PA, 945-971.
  • 11. Noureddıne, C., Harder, R., Olby, N.J., Spauldıng, K., Brown, T. (2004). Ultrasonographic appearance of dandy walker-like Syndrome in a Boston terrier. Vet Radiol Ultrasound, 45(4), 336-339.
  • 12. Okıta, M., Yanaı, T., Ochıkubos, F., Gemma, T., Morı, T., Masekı, T., Yamanouchı, K., Mikamı, T., Kaı, C. (1997). Histopathological features of canine distemper recently observed in Japan. J Comp Path, 116(4), 403-408.
  • 13. Saberı, M., Kheırandısh, R., Azızı, S., Mohebbı, E. (2014). Cerebellar cortical abiotrophy in a Samoyed dog. Eurasian J. Vet. Sci., 30(1), 44-47.
  • 14. Schatzberg, S.J., Haley, N.J., Barr, S.C., Parrısh, C., Steıngold, S., Summers, B.A., Delahunta, A., Kornegay, J.N., Sharp, N.J.H. (2003). Polymerase Chain Reaction (PCR) Amplification of Parvoviral DNA from the Brains of Dogs and Cats with Cerebellar Hypoplasia. J. Vet. Intern. Med, 17(4), 538-544.
  • 15. Sullıvan, N.D. (1985). The Nervous System. In: Jubb K.V.F., Kennedy P.C., Palmer N (ed’s), Pathology of Domestic Animals. 3th ed, Academic Press, London, 214-220.
  • 16. Summers, B., Cummıngs, J., Delahunta, A. (1994). Malformations of the Central Nervous System. Veterinary Neuropathology. Mosby, St Louis, 82-86.
  • 17. Summers, B.A., Cummings, J.F. (1995). De Lahunta A. Inflammatory diseases of the central nervous system. In: Duncan L, (ed’s), Veterinary Neuropathology. USA, Mosby Year Book, 102-110.
  • 18. Tago, Y., Katsuta, O., Tsuchıtanı, M. (1993). Granule cell type cerebellar hypoplasia in a beagle dog. Assoc Lab Anim Sci, 27(2), 151-155.
  • 19. Thompson, M.S. (2014). Small Animal Medical Differencial Diagnosis. Second Edition. Elsevier Saunders, Missouri, 227-228.
  • 20. Troxel, M.T. (2012). Neurology Case of the Month: Chronic, progressive ataxia in a Labrador http://www.ivghospitals.com/specialty-services/neurology-case-of-the-month-nov-2012-chronic-progressive-ataxia-in-a-labrador/ 18.07.2019.
  • 21. Yarasan, E. (2015). Kedi Köpek Hekimliği, Güneş kitapevleri.
  • 22. Yarım, G.F., Yagcı, B.B. (2006). Köpek gençlik hastalığının sinirsel formundaki köpeklerin plazmasında vitamin A ve beta-karotin düzeylerindeki degişiklikler, Ankara Univ. Vet. Fak. Derg, 53, 85-90.

Azawakh ırkı bir köpekte Cerebellar Hypoplasia: Olgu sunumu

Year 2020, Volume 5, Issue 1, 20 - 26, 30.04.2020
https://doi.org/10.31797/vetbio.622632

Abstract

Bu olgu sunumunda, dokuz aylık erkek Azawakh ırkı köpek, ataksi, koordinasyon bozukluğu, yürüme ve ayakta durma zorluğu, başta titremeler, dışkılama ve yemek yemede zorluk çekme şikayeti ile kliniğimize geldi. Manyetik rezonans görüntülemede hafif serebellar hipoplazi saptandı ve semptomatik tedavi amacı ile glukokortikoid, vitamin B1, B6 ve diazepam kullanıldı. Ancak köpek üç hafta sonra hayatını kaybetti. Nekropsisi yapılan köpekte makroskobik olarak cerebellar küçülme tespit edilirken, histopatolojik olarak serebellum ve granüler hücre hipoplazisi belirgindi. İmmünokimyasal olarak ise anti-GFAP antikoru ve vakuolar dejenerasyonu ile pozitif boyanma gösteren nöronal hücrelerin atrofisi belirlendi.

Klinik bulgular, MR görüntüleme, histopatolojik ve immunokimyasal bulgular doğrultusunda köpekte cerebellar hypoplasia teşhis edilmiş olup azawakh ırkı köpekte tespit edilen ilk olgu olması ile çalışmamız özgündür.

References

  • 1. Appel, M.J., Shek, W.R., Summers, B.A. (1982). Lymphocytemediated İmmune Cytotoxicity İn Dogs İnfected With Virulent Canine Distemper Virus. Infect. Immun, 37(2), 592- 600.
  • 2. Bernardıno, F., Rentmeıster, K., Schmıdt, M.J., Bruehschweın, A., Matıasek, K., Matıasek, L.A., Lauda, A., Schoon, H.A., Fischer, A. (2015). Inferior Cerebellar Hypoplasia Resembling a Dandy-Walker-Like Malformation in Purebred Eurasier Dogs with Familial Non-Progressive Ataxia: A Retrospective and Prospective Clinical Cohort Study. Plos One, 10(2).
  • 3. Choı, H., Kang, S.Y., Jeong, S., Cho, S., Lee, K., Eom, K., Lee, H., Chang, D., Yoon, J., Lee, Y. (2007). Imaging diagnosis-cerebellar vermis hypoplasia in a Miniature Schnauzer. Vet. Radiol. Ultrasound, 48(2), 129-131.
  • 4. Chrısman, C., Marıanı, C., Platt, S., Clemmons, R. (2003). Neurology for the Small Animal Practitioner. USA: Teton NewMedia. 204-205.
  • 5. De Lahunta, A. (1990). Abiotrophy in domestic animals: a review. Can J Vet Res, 54(1), 65-76.
  • 6. Flegel, T., Matıasek, K., Henke, D., Grevel, V. (2007). Cerebellar cortical degeneration with selective granule cell loss in Bavarian mountain dogs. J Small Anim Pract, 48(8), 462-465.
  • 7. Johnson, K.P., Ferguson, L.C., Byıngton, D.P., Redman, D.R. (1974). Multiple fetal malformations due to persistent viral infection. I. Abortion, intrauterine death, and gross abnormalities in fetal swine infected with hog cholera vaccine virus. Lab. Invest, 30(5), 608–617.
  • 8. Lım, J.H., Kım, D.Y., Yoon, J., Kım, W.H., Kweon, O. (2008). Cerebellar vermian hypoplasia in a Cocker Spaniel. J. Vet. Sci, 9(2), 215-217.
  • 9. Mackıllop, E. (2011). Magnetic resonance imaging of intracranial malformations in dogs and cats. Vet Radiol Ultrasound, 52(1), 42-51.
  • 10. March, P. (1996). Degenerative brain disease. In: Bagley R (ed’s), Intracranial Disease, Vet Clinics of North America. WB Saunders, Philadelphia, PA, 945-971.
  • 11. Noureddıne, C., Harder, R., Olby, N.J., Spauldıng, K., Brown, T. (2004). Ultrasonographic appearance of dandy walker-like Syndrome in a Boston terrier. Vet Radiol Ultrasound, 45(4), 336-339.
  • 12. Okıta, M., Yanaı, T., Ochıkubos, F., Gemma, T., Morı, T., Masekı, T., Yamanouchı, K., Mikamı, T., Kaı, C. (1997). Histopathological features of canine distemper recently observed in Japan. J Comp Path, 116(4), 403-408.
  • 13. Saberı, M., Kheırandısh, R., Azızı, S., Mohebbı, E. (2014). Cerebellar cortical abiotrophy in a Samoyed dog. Eurasian J. Vet. Sci., 30(1), 44-47.
  • 14. Schatzberg, S.J., Haley, N.J., Barr, S.C., Parrısh, C., Steıngold, S., Summers, B.A., Delahunta, A., Kornegay, J.N., Sharp, N.J.H. (2003). Polymerase Chain Reaction (PCR) Amplification of Parvoviral DNA from the Brains of Dogs and Cats with Cerebellar Hypoplasia. J. Vet. Intern. Med, 17(4), 538-544.
  • 15. Sullıvan, N.D. (1985). The Nervous System. In: Jubb K.V.F., Kennedy P.C., Palmer N (ed’s), Pathology of Domestic Animals. 3th ed, Academic Press, London, 214-220.
  • 16. Summers, B., Cummıngs, J., Delahunta, A. (1994). Malformations of the Central Nervous System. Veterinary Neuropathology. Mosby, St Louis, 82-86.
  • 17. Summers, B.A., Cummings, J.F. (1995). De Lahunta A. Inflammatory diseases of the central nervous system. In: Duncan L, (ed’s), Veterinary Neuropathology. USA, Mosby Year Book, 102-110.
  • 18. Tago, Y., Katsuta, O., Tsuchıtanı, M. (1993). Granule cell type cerebellar hypoplasia in a beagle dog. Assoc Lab Anim Sci, 27(2), 151-155.
  • 19. Thompson, M.S. (2014). Small Animal Medical Differencial Diagnosis. Second Edition. Elsevier Saunders, Missouri, 227-228.
  • 20. Troxel, M.T. (2012). Neurology Case of the Month: Chronic, progressive ataxia in a Labrador http://www.ivghospitals.com/specialty-services/neurology-case-of-the-month-nov-2012-chronic-progressive-ataxia-in-a-labrador/ 18.07.2019.
  • 21. Yarasan, E. (2015). Kedi Köpek Hekimliği, Güneş kitapevleri.
  • 22. Yarım, G.F., Yagcı, B.B. (2006). Köpek gençlik hastalığının sinirsel formundaki köpeklerin plazmasında vitamin A ve beta-karotin düzeylerindeki degişiklikler, Ankara Univ. Vet. Fak. Derg, 53, 85-90.

Details

Primary Language English
Subjects Veterinary Sciences
Journal Section Case Reports
Authors

Pelin Fatoş POLAT (Primary Author)
HARRAN ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ, KLİNİK BİLİMLER BÖLÜMÜ
0000-0003-4885-6513
Türkiye


Gürbüz AKSOY This is me
HARRAN ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ, KLİNİK BİLİMLER BÖLÜMÜ
0000-0002-3455-0612
Türkiye


Rabia ALTUNTAŞ This is me
Mehmet Akif İnan Eğitim ve Araştırma Hastanesi Tıbbi laboratuvar Bölümü
0000-0002-5356-1448
Türkiye


İsmail ÇETİNTAŞ This is me
HARRAN ÜNİVERSİTESİ, TIP FAKÜLTESİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ, TIBBİ PATOLOJİ ANABİLİM DALI
0000-0002-0785-985X
Türkiye

Publication Date April 30, 2020
Application Date September 20, 2019
Acceptance Date April 8, 2020
Published in Issue Year 2020, Volume 5, Issue 1

Cite

APA Polat, P. F. , Aksoy, G. , Altuntaş, R. & Çetintaş, İ. (2020). Cerebellar hypoplasia in an Azawakh dog: A case report . Journal of Advances in VetBio Science and Techniques , 5 (1) , 20-26 . DOI: 10.31797/vetbio.622632

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