Year 2020, Volume 5 , Issue 1, Pages 20 - 26 2020-04-30

Azawakh ırkı bir köpekte Cerebellar Hypoplasia: Olgu sunumu
Cerebellar hypoplasia in an Azawakh dog: A case report

Pelin Fatoş POLAT [1] , Gürbüz AKSOY [2] , Rabia ALTUNTAŞ [3] , İsmail ÇETİNTAŞ [4]


Bu olgu sunumunda, dokuz aylık erkek Azawakh ırkı köpek, ataksi, koordinasyon bozukluğu, yürüme ve ayakta durma zorluğu, başta titremeler, dışkılama ve yemek yemede zorluk çekme şikayeti ile kliniğimize geldi. Manyetik rezonans görüntülemede hafif serebellar hipoplazi saptandı ve semptomatik tedavi amacı ile glukokortikoid, vitamin B1, B6 ve diazepam kullanıldı. Ancak köpek üç hafta sonra hayatını kaybetti. Nekropsisi yapılan köpekte makroskobik olarak cerebellar küçülme tespit edilirken, histopatolojik olarak serebellum ve granüler hücre hipoplazisi belirgindi. İmmünokimyasal olarak ise anti-GFAP antikoru ve vakuolar dejenerasyonu ile pozitif boyanma gösteren nöronal hücrelerin atrofisi belirlendi.

Klinik bulgular, MR görüntüleme, histopatolojik ve immunokimyasal bulgular doğrultusunda köpekte cerebellar hypoplasia teşhis edilmiş olup azawakh ırkı köpekte tespit edilen ilk olgu olması ile çalışmamız özgündür.

In this case report, the nine-month-old male Azawakh dog  was observed to ataxia, uncoordinated move­ments, difficulties in walking and standing, intensive head tremors, trouble evacuating and eating. It was determined mild cerebellar hypoplasia at the magnetic resonance imaging. Symptomatic treatment was started with glu­cocorticoids, vitamin B1, B6and diazepam. But these drugs had no effect on symptoms and the dog died after three weeks. It described a macroscopic cerebellar reduction in the necropsy and cerebellum and granular cell hypoplasia in histopathologically. Immunohistochemically, the atrophy of neuronal cells showing positive staining with anti-GFAP antibody and vacuolar degeneration were identified.

Based on clinical findings, MR imaging, histopathological and immunochemical findings, cerebellar hypoplasia was diagnosed in the dog and this study is the first case detected in the Azawakh dog.

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Primary Language en
Subjects Veterinary Sciences
Journal Section Case Reports
Authors

Orcid: 0000-0003-4885-6513
Author: Pelin Fatoş POLAT (Primary Author)
Institution: HARRAN ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ, KLİNİK BİLİMLER BÖLÜMÜ
Country: Turkey


Orcid: 0000-0002-3455-0612
Author: Gürbüz AKSOY
Institution: HARRAN ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ, KLİNİK BİLİMLER BÖLÜMÜ
Country: Turkey


Orcid: 0000-0002-5356-1448
Author: Rabia ALTUNTAŞ
Institution: Mehmet Akif İnan Eğitim ve Araştırma Hastanesi Tıbbi laboratuvar Bölümü
Country: Turkey


Orcid: 0000-0002-0785-985X
Author: İsmail ÇETİNTAŞ
Institution: HARRAN ÜNİVERSİTESİ, TIP FAKÜLTESİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ, TIBBİ PATOLOJİ ANABİLİM DALI
Country: Turkey


Dates

Application Date : September 20, 2019
Acceptance Date : April 8, 2020
Publication Date : April 30, 2020

Bibtex @case report { vetbio622632, journal = {Journal of Advances in VetBio Science and Techniques}, issn = {}, eissn = {2548-1150}, address = {Aksaray Üniversitesi Veteriner Fakültesi Merkez Kampüs Adana yolu 7.km AKSARAY}, publisher = {İlker ÇAMKERTEN}, year = {2020}, volume = {5}, pages = {20 - 26}, doi = {10.31797/vetbio.622632}, title = {Cerebellar hypoplasia in an Azawakh dog: A case report}, key = {cite}, author = {Polat, Pelin Fatoş and Aksoy, Gürbüz and Altuntaş, Rabia and Çeti̇ntaş, İsmail} }
APA Polat, P , Aksoy, G , Altuntaş, R , Çeti̇ntaş, İ . (2020). Cerebellar hypoplasia in an Azawakh dog: A case report . Journal of Advances in VetBio Science and Techniques , 5 (1) , 20-26 . DOI: 10.31797/vetbio.622632
MLA Polat, P , Aksoy, G , Altuntaş, R , Çeti̇ntaş, İ . "Cerebellar hypoplasia in an Azawakh dog: A case report" . Journal of Advances in VetBio Science and Techniques 5 (2020 ): 20-26 <https://dergipark.org.tr/en/pub/vetbio/issue/53988/622632>
Chicago Polat, P , Aksoy, G , Altuntaş, R , Çeti̇ntaş, İ . "Cerebellar hypoplasia in an Azawakh dog: A case report". Journal of Advances in VetBio Science and Techniques 5 (2020 ): 20-26
RIS TY - JOUR T1 - Cerebellar hypoplasia in an Azawakh dog: A case report AU - Pelin Fatoş Polat , Gürbüz Aksoy , Rabia Altuntaş , İsmail Çeti̇ntaş Y1 - 2020 PY - 2020 N1 - doi: 10.31797/vetbio.622632 DO - 10.31797/vetbio.622632 T2 - Journal of Advances in VetBio Science and Techniques JF - Journal JO - JOR SP - 20 EP - 26 VL - 5 IS - 1 SN - -2548-1150 M3 - doi: 10.31797/vetbio.622632 UR - https://doi.org/10.31797/vetbio.622632 Y2 - 2020 ER -
EndNote %0 Journal of Advances in VetBio Science and Techniques Cerebellar hypoplasia in an Azawakh dog: A case report %A Pelin Fatoş Polat , Gürbüz Aksoy , Rabia Altuntaş , İsmail Çeti̇ntaş %T Cerebellar hypoplasia in an Azawakh dog: A case report %D 2020 %J Journal of Advances in VetBio Science and Techniques %P -2548-1150 %V 5 %N 1 %R doi: 10.31797/vetbio.622632 %U 10.31797/vetbio.622632
ISNAD Polat, Pelin Fatoş , Aksoy, Gürbüz , Altuntaş, Rabia , Çeti̇ntaş, İsmail . "Cerebellar hypoplasia in an Azawakh dog: A case report". Journal of Advances in VetBio Science and Techniques 5 / 1 (April 2020): 20-26 . https://doi.org/10.31797/vetbio.622632
AMA Polat P , Aksoy G , Altuntaş R , Çeti̇ntaş İ . Cerebellar hypoplasia in an Azawakh dog: A case report. J. Adv. VetBio Sci. Tech.. 2020; 5(1): 20-26.
Vancouver Polat P , Aksoy G , Altuntaş R , Çeti̇ntaş İ . Cerebellar hypoplasia in an Azawakh dog: A case report. Journal of Advances in VetBio Science and Techniques. 2020; 5(1): 20-26.
IEEE P. Polat , G. Aksoy , R. Altuntaş and İ. Çeti̇ntaş , "Cerebellar hypoplasia in an Azawakh dog: A case report", Journal of Advances in VetBio Science and Techniques, vol. 5, no. 1, pp. 20-26, Apr. 2020, doi:10.31797/vetbio.622632