Cerebellar hypoplasia in an Azawakh dog: A case report

Year 2020, Volume 5, Issue 1, 20 - 26, 30.04.2020

Pelin Fatoş POLAT Gürbüz AKSOY Rabia ALTUNTAŞ İsmail ÇETİNTAŞ

https://doi.org/10.31797/vetbio.622632

Abstract

In this case report, the nine-month-old male Azawakh dog  was observed to ataxia, uncoordinated move­ments, difficulties in walking and standing, intensive head tremors, trouble evacuating and eating. It was determined mild cerebellar hypoplasia at the magnetic resonance imaging. Symptomatic treatment was started with glu­cocorticoids, vitamin B₁, B₆and diazepam. But these drugs had no effect on symptoms and the dog died after three weeks. It described a macroscopic cerebellar reduction in the necropsy and cerebellum and granular cell hypoplasia in histopathologically. Immunohistochemically, the atrophy of neuronal cells showing positive staining with anti-GFAP antibody and vacuolar degeneration were identified.

Based on clinical findings, MR imaging, histopathological and immunochemical findings, cerebellar hypoplasia was diagnosed in the dog and this study is the first case detected in the Azawakh dog.

Keywords

Azawakh, dog, cerebellar hypoplasia

Azawakh ırkı bir köpekte Cerebellar Hypoplasia: Olgu sunumu

Abstract

Bu olgu sunumunda, dokuz aylık erkek Azawakh ırkı köpek, ataksi, koordinasyon bozukluğu, yürüme ve ayakta durma zorluğu, başta titremeler, dışkılama ve yemek yemede zorluk çekme şikayeti ile kliniğimize geldi. Manyetik rezonans görüntülemede hafif serebellar hipoplazi saptandı ve semptomatik tedavi amacı ile glukokortikoid, vitamin B₁, B₆ ve diazepam kullanıldı. Ancak köpek üç hafta sonra hayatını kaybetti. Nekropsisi yapılan köpekte makroskobik olarak cerebellar küçülme tespit edilirken, histopatolojik olarak serebellum ve granüler hücre hipoplazisi belirgindi. İmmünokimyasal olarak ise anti-GFAP antikoru ve vakuolar dejenerasyonu ile pozitif boyanma gösteren nöronal hücrelerin atrofisi belirlendi.

Klinik bulgular, MR görüntüleme, histopatolojik ve immunokimyasal bulgular doğrultusunda köpekte cerebellar hypoplasia teşhis edilmiş olup azawakh ırkı köpekte tespit edilen ilk olgu olması ile çalışmamız özgündür.

Keywords

Azawakh, köpek, serebellar hipoplazisi

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