INVESTIGATION OF THE ROLE OF STRESS IN MALE INFERTILITY AND THE EFFECT OF CURRENT MELATONIN HORMONE TREATMENTS

Year 2023, , 36 - 48, 06.05.2023

İshak Gökçek , Leyla Aydın

https://doi.org/10.38137/vftd.1221071

Abstract

Although stress, defined as the deterioration in homeostatic mechanisms in living things due to psychological, physiological, social, and even environmental reasons, has been mentioned since the 17th century, it is frequently encountered in modern life. So much so that you can be exposed to stress anytime, from home, business life, to the street, in traffic. This situation has made stress a part of modern life. Any situation or event, such as losing a close person, workplace stress, or even living in isolation at home during the coronavirus disease (COVID-19) pandemic, can also be a source of stress. Responses that occur in the organism to the stress stimulus are for the benefit of the organism up to a certain level. However, when the duration and intensity of the stress stimulus increase, pathological conditions occur in all physiological systems. Long-term exposure to stress may cause infertility in men by causing decreases in sperm parameters such as sperm quality, sperm concentration, spermatozoid count, and sperm percentage. Various substances are being researched to reduce these adverse effects of stress on the reproductive system. Studies have shown that melatonin has antioxidant, anti-inflammatory, anti-apoptotic, and so on. It shows positive efficacy in male infertility with various mechanisms. This review it is aimed to give information on the effect of stress on the male reproductive system and the relationship between melatonin.

Keywords

Male infertility, Melatonin, Sperm, Stress

ERKEK İNFERTİLİTESİNDE STRESİN ROLÜ VE UYGULANAN GÜNCEL MELATONİN HORMON TEDAVİLERİNİN ETKİSİNİN İNCELENMESİ

Abstract

Psikolojik, fizyolojik, sosyal hatta çevresel kaynaklı nedenlerle canlıda ki homeostatik mekanizmalarda meydana gelen bozulmalar şeklinde tanımlanan stres kavramı üzerinde 17 yüzyıldan bu yana bahsedilmekle birlikte modern yaşamda sıklıkla karşımıza çıkmaktadır. Öyle ki ev, iş yaşamından tutun sokakta, trafikte yaşamın herhangi bir anında strese maruz kalınabilmektedir. Bu durum stresi modern yaşamın bir parçası haline getirmiştir. Yakın birini kaybı, işyeri stresi hatta COVID 19 pandemisinde bireylerin evlerde izole bir şekilde yaşamı gibi herhangi bir durum veya olay da stres kaynağı olabilmektedir. Strese uyaranına karşı canlıda meydana gelen yanıtlar belirli bir düzeye kadar canlının faydasına yöneliktir. Ancak stres uyaranın süresi ve şiddetinin artması durumlarında tüm fizyolojik sistemlerde patolojik durumlar şekillenmektedir. Uzun süreli stres maruziyeti, sperm kalitesi, sperm konsantrasyonu, spermatozoit sayısı, sperm yüzdesi gibi sperm parametrelerinde azalmalara neden olarak erkeklerde infertiliteye yol açabilmektedir. Stresin üreme sistemindeki bu olumsuz etkilerini azaltmak adına çeşitli maddeler araştırılmaktadır. Yapılan çalışmalarda melatoninin antioksidan, anti-inflamatuar, anti-apipotik vb. mekanizmalar ile erkek infertilitesinde olumlu etkinlik göstermektedir. Bu derlemede stresin erkek üreme sistemi üzerine etkisi ve melatonin ilişkisi üzerinde bilgi verilmesi amaçlanmaktadır.

Keywords

Erkek infertilitesi, Melatonin, Sperm, Stres

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