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THERAPEUTIC HELMINTHS: A NEW PERSPECTIVE AGAINST THE PARASITE

Year 2019, Volume: 10 Issue: 2, 49 - 59, 21.08.2019

Güneş Karakurt Kader Yıldız

Abstract

An important increase is observed in the prevalence of allergic and autoimmune diseases in developed countries. Differences of immunological responses between parasitic infections and autoimmune or allergic diseases in the organism suggest the use of parasites as therapeutic agent in these diseases. The emergence of new information in this regard is expected to open a new horizon in the treatment of allergic and autoimmune diseases. With this review, it is aimed to give information about therapeutic helminths.

Keywords

Helminth therapy otoimmun diseases allergy

References

  • Asher, M.I., Montefort, S., Bjorksten, B., Lai, C.K.W., Strachan, D.P., Weiland, S.K., Williams H & ISAAC Phase Three Study Group (2006). Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC phases One and three repeat multicountry cross-sectional surveys. Lancet, 368, 733–743.
  • Barbara, G., Xing, Z., Hogaboam, C.M, Gauldie, J. & Collins, S.M. (2000). Interleukin 10 gene transfer prevents experimental colitis in rats. Gut, 46, 344–349.
  • Bethony, J., Brooker, S., Albonico, M., Geiger, S.M., Loukas, A., Diemert, D. & Hotez, P.J. (2006). Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm. Lancet, 367(9521), 1521–1532.
  • Chen, C.C., Louie, S., Mc Cormick, B., Walker, W.A. & Shi, H.N. (2005). Concurrent infection with an intestinal helminth parasite impairs host resistance to enteric Citrobacter rodentium and enhances Citrobacter-induced colitis in mice. Infection and Immunology, 73, 5468–5481.
  • Chen, C.C., Louie, S., Mc Cormick, B., Walker, W.A. & Shi, H.N. (2006) Helminth-primed dendritic cells alter the host response to enteric bacterial infection. Journal of Immunology, 176, 472–483.
  • Cookson, W.O. & Moffatt, M.F. (1997). Asthma: An epidemic in the absence of infection? Science, 275, 41–42.
  • Cooper, P.J. (2009). Interactions between helminth parasites and allergy. Current Opinion of Allergy Clinical Immunology, 9, 29-37.
  • Correale, J. & Farez, M. (2007). Association between parasite infection and immune responses in multiple sclerosis. Annals of Neurology, 61, 97–108.
  • Croese, J., O’neil, J., Masson, J., Cooke, S., Melrose, W., Pritchard, D. & Speare, R. (2006). A proof of concept study establishing Necator americanus in Crohn’s patients and reservoir donors. Gut, 55, 136–137.
  • Daveson, A.J., Jones, D.M., Gaze, S., McSorley, H., Clouston, A., Pascoe, A., Cooke, S., Speare, R., MacDonald, G.A., Anderson, R., McCarthy, J.S., Loukas, A. & Croese, J. (2011). Effect of hookworm infection on wheat challenge in celiac disease‚ a randomised double-blinded placebo controlled trial. PLoS One, 6, e17366.
  • Diker, S.K. (2005). Immunoloji, 2. baskı, Medisan, Ankara.
  • Fallon, P.G., Richardson, E.J., Smith, P. & Dunne, D.W. (2000). Elevated type 1, diminished type 2 cytokines and impaired antibody response are associated with hepatotoxicity and mortalities during Schistosoma mansoni infection of CD4-depleted mice. European Journal of Immunology, 30, 470–480.
  • Harnett, W. (2014). Secretory products of helminth parasites as immunomodulators. Molecular and Biochemical Parasitology, 195, 130–136.
  • Harnett, W. & Harnett, M.M. (2008). Therapeutic immunomodulators from nematode parasites. Expert Reviews in Molecular Medicine, 10, 18–28.
  • Helmby, H. (2009). Helminths and our immune system: friend or foe? Parasitology International, 58, 121–127.
  • Helmby, H. (2015). Human helminth therapy to treat inflammatory disorders-where do we stand? BMC Immunology, 16, 1.
  • Khan, R. & Fallon, P.G. (2013). Helminth therapies: Translating the unknown unknowns to known knowns. International Journal for Parasitology, 43, 293–299.
  • King, C.L., Malhotra, I., Mungai, P., Wamachi, A., Kioko, J., Ouma, J.H. & Kazura, J.W. (1998). B cell sensitization to helminthic infection develops in utero in humans. Journal of Immunology, 160, 3578–3584.
  • Kradin, R.L., Badizadegan, K., Auluck, P., Korzenik, J. & Lauwers, G.Y. (2006). Iatrogenic Trichuris suis infection in a patient with Crohn’s disease. Archives of Pathology & Laboratory Medicine, 130, 718–720.
  • Leonardi-Bee, J., Pritchard, D.I. & Britton, J. (2006). Asthma and current intestinal parasite infection: systematic review and meta-analysis. American Journal of Respiratory and Critical Care Medicine, 174, 514–523.
  • Lydyard, P., Whelan, A., Fanger, M. (2011). BIOS Instant Notes in Immunology. Taylor & Francis Group, New York and London.
  • Mangan, N.E., Vanrooijen, N., McKenzie, A.N. & Fallon, P.G. (2006). Helminth-modified pulmonary immune response protects mice from allergen-induced airway hyperresponsiveness. Journal of Immunology, 176, 138–147.
  • McKay, D.M. (2009). The therapeutic helminth? Trends in Parasitology, 25, 110-114.
  • Middleton, E., Reed, C.E., Ellis, E.F., Adkinson, N.F., Yunginger, J.W. & Buse, W.W. (1998). Allergy, Volume II. 5th edition. Mosby-Year Book Inc, St Louis, Missouri.
  • Nicolaou, N., Siddique, N. & Custovic, A. (2005). Allergic disease in urban and rural populations: increasing prevalence with increasing urbanization, Allergy, 60, 1357–1360.
  • Pritchard, D.I. (2011). Worm therapy: for or against? Journal of Helminthology, 85, 225–227.
  • Reyes, J.L. & Terrazas, L.I. (2007). The divergent roles of alternatively activated macrophages in helminthic infections. Parasite Immunology. 29, 609–619.
  • Smits, H.H. & Yazdanbakhsh, M. (2007). Chronic helminth infections modulate allergen-specific immune responses: protection against development of allergic disorders? Annals of Medicine, 39, 428–39.
  • Smits, H.H., Hammad, H., van Nimwegen, M., Soullie, T., Willart, M.A., Lievers, E., Kadouch, J., Kool, M., Kos van Oosterhoud, J., Deelder, A.M., Lambrecht, B.N. & Yazdanbakhsh, M. (2007). Protective effect of Schistosoma mansoni infection on allergic airway inflammation depends on the intensity and chronicity of infection. Journal of Allergy and Clinical Immunology, 120, 932–940.
  • Steinhart, H. (2001). Clinical perspectives – biologics in IBD: what’s all the fuss? Canadian Journal of Gastroenterology, 15, 799–804.
  • Summers, R.W., Elliott, D.E., Qadir, K., Urban, J.F.J., Thompson, R. & Weinstock, J.V. (2003). Trichuris suis seems to be safe and possibly effective in the treatment of inflammatory bowel disease. American Journal of Gastroenterology, 98, 2034–2041.
  • Summers, R.W., Elliott, D.E., Urban, J.F.J., Thompson, R. & Weinstock, J.V. (2005a). Trichuris suis therapy in Crohn’s disease. Gut, 54, 87–90.
  • Summers, R.W., Elliott, D.E., Urban, J.F.J., Thompson, R.A. & Weinstock, J.V. (2005b). Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial. Gastroenterology, 128, 825–832.
  • Taylor, A., Verhagen, J., Akdis, C.A. & Akdis, M. (2004). T regulatory cells in allergy and health: A question of allergen specificity and balance, International Archive of Allergy and Immunology, 135, 73–82.
  • Taylor, M.D., van der Werf, N. & Maizels, R.M. (2012). T cells in helminth infection: the regulators and the regulated. Trends in Immunology, 33, 181–189.
  • Van den Biggelaar, A.H., Rodrigues, L.C., Van Ree, R., Van der Zee, J.S., Hoeksma-Kruize, Y.C., Souverijn, J.H., Missinou, M.A., Borrmann, S., Kremsner, P.G. & Yazdanbakhsh, M. (2004). Long-term treatment of intestinal helminths increases mite skin-test reactivity in Gabonese schoolchildren. Journal of Infectious Diseases, 189, 892–900.
  • Von Mutius, E. & Vercelli, D. (2010). Farm living: effects on childhood asthma and allergy. Nature Reviews of Immunology, 10, 861–868.
  • Weinstock, J.V., Summers, R.W., Elliott, D.E., Qadir, K., Urban, J.F. Jr & Thompson, R. (2002). The possible link between de-worming and the emergence of immunological disease. Journal of Laboratory and Clinical Medicine, 139, 334– 338.

TEDAVİ EDİCİ HELMİNTLER: PARAZİTE YENİ BIR BAKIŞ AÇISI

Year 2019, Volume: 10 Issue: 2, 49 - 59, 21.08.2019

Güneş Karakurt Kader Yıldız

Abstract

Gelişmiş
ülkelerde otoimmun ve alerjik hastalıkların yaygınlığında önemli bir artış
izlenmektedir. Organizmada otoimmun veya alerjik hastalıklar ile parazitik
enfeksiyonlarına karşı şekillenen immun yanıtlardaki farklılıklar bu
hastalıklarda parazitlerin teröpatik olarak kullanımını düşündürmektedir. Bu
konuda yeni bilgilerin ortaya çıkması ile otoimmun ve alerjik hastalıkların
tedavisinde yeni ufuklar açacağı düşünülmektedir. Bu derleme ile helmint tedavi
hakkında bilgi vermek amaçlanmıştır.

Keywords

Helmint tedavi otoimmun hastalık

References

  • Asher, M.I., Montefort, S., Bjorksten, B., Lai, C.K.W., Strachan, D.P., Weiland, S.K., Williams H & ISAAC Phase Three Study Group (2006). Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC phases One and three repeat multicountry cross-sectional surveys. Lancet, 368, 733–743.
  • Barbara, G., Xing, Z., Hogaboam, C.M, Gauldie, J. & Collins, S.M. (2000). Interleukin 10 gene transfer prevents experimental colitis in rats. Gut, 46, 344–349.
  • Bethony, J., Brooker, S., Albonico, M., Geiger, S.M., Loukas, A., Diemert, D. & Hotez, P.J. (2006). Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm. Lancet, 367(9521), 1521–1532.
  • Chen, C.C., Louie, S., Mc Cormick, B., Walker, W.A. & Shi, H.N. (2005). Concurrent infection with an intestinal helminth parasite impairs host resistance to enteric Citrobacter rodentium and enhances Citrobacter-induced colitis in mice. Infection and Immunology, 73, 5468–5481.
  • Chen, C.C., Louie, S., Mc Cormick, B., Walker, W.A. & Shi, H.N. (2006) Helminth-primed dendritic cells alter the host response to enteric bacterial infection. Journal of Immunology, 176, 472–483.
  • Cookson, W.O. & Moffatt, M.F. (1997). Asthma: An epidemic in the absence of infection? Science, 275, 41–42.
  • Cooper, P.J. (2009). Interactions between helminth parasites and allergy. Current Opinion of Allergy Clinical Immunology, 9, 29-37.
  • Correale, J. & Farez, M. (2007). Association between parasite infection and immune responses in multiple sclerosis. Annals of Neurology, 61, 97–108.
  • Croese, J., O’neil, J., Masson, J., Cooke, S., Melrose, W., Pritchard, D. & Speare, R. (2006). A proof of concept study establishing Necator americanus in Crohn’s patients and reservoir donors. Gut, 55, 136–137.
  • Daveson, A.J., Jones, D.M., Gaze, S., McSorley, H., Clouston, A., Pascoe, A., Cooke, S., Speare, R., MacDonald, G.A., Anderson, R., McCarthy, J.S., Loukas, A. & Croese, J. (2011). Effect of hookworm infection on wheat challenge in celiac disease‚ a randomised double-blinded placebo controlled trial. PLoS One, 6, e17366.
  • Diker, S.K. (2005). Immunoloji, 2. baskı, Medisan, Ankara.
  • Fallon, P.G., Richardson, E.J., Smith, P. & Dunne, D.W. (2000). Elevated type 1, diminished type 2 cytokines and impaired antibody response are associated with hepatotoxicity and mortalities during Schistosoma mansoni infection of CD4-depleted mice. European Journal of Immunology, 30, 470–480.
  • Harnett, W. (2014). Secretory products of helminth parasites as immunomodulators. Molecular and Biochemical Parasitology, 195, 130–136.
  • Harnett, W. & Harnett, M.M. (2008). Therapeutic immunomodulators from nematode parasites. Expert Reviews in Molecular Medicine, 10, 18–28.
  • Helmby, H. (2009). Helminths and our immune system: friend or foe? Parasitology International, 58, 121–127.
  • Helmby, H. (2015). Human helminth therapy to treat inflammatory disorders-where do we stand? BMC Immunology, 16, 1.
  • Khan, R. & Fallon, P.G. (2013). Helminth therapies: Translating the unknown unknowns to known knowns. International Journal for Parasitology, 43, 293–299.
  • King, C.L., Malhotra, I., Mungai, P., Wamachi, A., Kioko, J., Ouma, J.H. & Kazura, J.W. (1998). B cell sensitization to helminthic infection develops in utero in humans. Journal of Immunology, 160, 3578–3584.
  • Kradin, R.L., Badizadegan, K., Auluck, P., Korzenik, J. & Lauwers, G.Y. (2006). Iatrogenic Trichuris suis infection in a patient with Crohn’s disease. Archives of Pathology & Laboratory Medicine, 130, 718–720.
  • Leonardi-Bee, J., Pritchard, D.I. & Britton, J. (2006). Asthma and current intestinal parasite infection: systematic review and meta-analysis. American Journal of Respiratory and Critical Care Medicine, 174, 514–523.
  • Lydyard, P., Whelan, A., Fanger, M. (2011). BIOS Instant Notes in Immunology. Taylor & Francis Group, New York and London.
  • Mangan, N.E., Vanrooijen, N., McKenzie, A.N. & Fallon, P.G. (2006). Helminth-modified pulmonary immune response protects mice from allergen-induced airway hyperresponsiveness. Journal of Immunology, 176, 138–147.
  • McKay, D.M. (2009). The therapeutic helminth? Trends in Parasitology, 25, 110-114.
  • Middleton, E., Reed, C.E., Ellis, E.F., Adkinson, N.F., Yunginger, J.W. & Buse, W.W. (1998). Allergy, Volume II. 5th edition. Mosby-Year Book Inc, St Louis, Missouri.
  • Nicolaou, N., Siddique, N. & Custovic, A. (2005). Allergic disease in urban and rural populations: increasing prevalence with increasing urbanization, Allergy, 60, 1357–1360.
  • Pritchard, D.I. (2011). Worm therapy: for or against? Journal of Helminthology, 85, 225–227.
  • Reyes, J.L. & Terrazas, L.I. (2007). The divergent roles of alternatively activated macrophages in helminthic infections. Parasite Immunology. 29, 609–619.
  • Smits, H.H. & Yazdanbakhsh, M. (2007). Chronic helminth infections modulate allergen-specific immune responses: protection against development of allergic disorders? Annals of Medicine, 39, 428–39.
  • Smits, H.H., Hammad, H., van Nimwegen, M., Soullie, T., Willart, M.A., Lievers, E., Kadouch, J., Kool, M., Kos van Oosterhoud, J., Deelder, A.M., Lambrecht, B.N. & Yazdanbakhsh, M. (2007). Protective effect of Schistosoma mansoni infection on allergic airway inflammation depends on the intensity and chronicity of infection. Journal of Allergy and Clinical Immunology, 120, 932–940.
  • Steinhart, H. (2001). Clinical perspectives – biologics in IBD: what’s all the fuss? Canadian Journal of Gastroenterology, 15, 799–804.
  • Summers, R.W., Elliott, D.E., Qadir, K., Urban, J.F.J., Thompson, R. & Weinstock, J.V. (2003). Trichuris suis seems to be safe and possibly effective in the treatment of inflammatory bowel disease. American Journal of Gastroenterology, 98, 2034–2041.
  • Summers, R.W., Elliott, D.E., Urban, J.F.J., Thompson, R. & Weinstock, J.V. (2005a). Trichuris suis therapy in Crohn’s disease. Gut, 54, 87–90.
  • Summers, R.W., Elliott, D.E., Urban, J.F.J., Thompson, R.A. & Weinstock, J.V. (2005b). Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial. Gastroenterology, 128, 825–832.
  • Taylor, A., Verhagen, J., Akdis, C.A. & Akdis, M. (2004). T regulatory cells in allergy and health: A question of allergen specificity and balance, International Archive of Allergy and Immunology, 135, 73–82.
  • Taylor, M.D., van der Werf, N. & Maizels, R.M. (2012). T cells in helminth infection: the regulators and the regulated. Trends in Immunology, 33, 181–189.
  • Van den Biggelaar, A.H., Rodrigues, L.C., Van Ree, R., Van der Zee, J.S., Hoeksma-Kruize, Y.C., Souverijn, J.H., Missinou, M.A., Borrmann, S., Kremsner, P.G. & Yazdanbakhsh, M. (2004). Long-term treatment of intestinal helminths increases mite skin-test reactivity in Gabonese schoolchildren. Journal of Infectious Diseases, 189, 892–900.
  • Von Mutius, E. & Vercelli, D. (2010). Farm living: effects on childhood asthma and allergy. Nature Reviews of Immunology, 10, 861–868.
  • Weinstock, J.V., Summers, R.W., Elliott, D.E., Qadir, K., Urban, J.F. Jr & Thompson, R. (2002). The possible link between de-worming and the emergence of immunological disease. Journal of Laboratory and Clinical Medicine, 139, 334– 338.
There are 38 citations in total.

Details

Primary Language Turkish
Subjects Veterinary Sciences
Journal Section Review
Authors

Güneş Karakurt This is me

Kader Yıldız 0000-0001-5802-6156

Publication Date August 21, 2019
Acceptance Date May 21, 2019
Published in Issue Year 2019 Volume: 10 Issue: 2

Cite

APA Karakurt, G., & Yıldız, K. (2019). TEDAVİ EDİCİ HELMİNTLER: PARAZİTE YENİ BIR BAKIŞ AÇISI. Veteriner Farmakoloji Ve Toksikoloji Derneği Bülteni, 10(2), 49-59.
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