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MACROCYCLIC LACTONES IN THE TREATMENT OF PARASITIC DISEASES IN DOGS AND CATS

Year 2023, Volume: 14 Issue: 2, 88 - 97, 01.09.2023
https://doi.org/10.38137/vftd.1283923

Abstract

Macrocyclic lactones are licensed for the treatment of some parasites in dogs and cats. These compounds are also used off-label in the treatment of parasites. The aim of the review was to give information about the use of macrocyclic lactones in dogs and cats parasites.

References

  • Arthur, R. G., Bowman, D. D., Slone, R. L. & Travis, L. E. (2005). Imidacloprid plus moxidectin topical solution for the prevention of heartworm disease (Dirofiloria immitis) in dogs. Parasitology Research, 97 (Suppl 1), S76-S80.
  • Bahçivan, E. & Oğuz, H. (2019). Zehirlenmelerde intravenöz lipit emülsiyonu tedavisi. Dicle Üniversitesi Veteriner Fakültesi Dergisi, 12, 70–77.
  • Bates, N., Chatterton, J., Robbins, C., Wells, K., Hughes, J., Stone, M. & Campbell, A. (2013). Lipid infusion in the management of poisoning: a report of 6 canine cases. Veterinary Record, 172, 339.
  • Bishop, B. F., Bruce, C. I., Evans, N. A., Goudie, A. C., Gration, K. A., Gibson, S. P., Pacey, M. S., Perry, D. A., Walshe, N. D. & Witty, M. J. (2000). Selamectin: a novel broad-spectrum endectocide for dogs and cats. Veterinary Parasitology, 91, 163-176.
  • Blagburn, B. L., Hendrix, C. M., Lindsay, D. S. & Vaughan, J. L. (1987). Anthelmintic efficacy of ivermectin in naturally parasitized cats. American Journal of Veterinary Research, 48, 670-672.
  • Blagburn, B. L., Hendrix, C. M., Lindsay, D. S., Vaughan, J. L., Hepler, D. I. & Wright, J. C. (1992). Efficacy of milbemycin oxime against naturally acquired or experimentally induced Ancylostoma spp. and Trichuris vulpis infections in dogs. American Journal of Veterinary Research, 53, 513-516.
  • Bowman, D. D., Lin, D. S., Johnson, R. C. & Hepler, D. I. (1991). Effect of milbemycin oxime on adult Ancylostoma caninum and Uncinaria stenocephala in dogs with experimentally induced infections. American Journal of Veterinary Research, 52, 64-67.
  • Bowman, D. D. (2014). Georgis’ Parasitology for Veterinarians. 10th ed. St Louis Missouri: Elsevier Saunders. Boy, M. G., Six, R. H., Thomas, C. A., Novotny, M. J., Smothers, C. D., Rowan, T. G. & Jernigan, A. D. (2000). Efficacy and safety of selamectin against fleas and heartworms in dogs and cats presented as veterinary patients in North America. Veterinary Parasitology, 91, 233-250.
  • Crandell, D. E. & Weinberg, G. L. (2009). Moxidectin toxicosis in a puppy successfully treated with intravenous lipids. Journal of Veterinary Emergency and Critical Care, 19, 181-186.
  • El-Saber Batiha, G., Alqahtani, A., Ilesanmi, O. B., Saati, A. A., El-Mleeh, A., Hetta, H. F. & Magdy Beshbishy, A. (2020). Avermectin derivatives, pharmacokinetics, therapeutic and toxic dosages, mechanism of action, and their biological effects. Pharmaceuticals (Basel), 13, 196.
  • Geyer, J. & Janko, C. (2012). Treatment of MDR1 mutant dogs with macrocyclic lactones. Current Pharmaceutical Biotechnology, 13, 969-986.
  • Grieve, R. B., Frank, G. R., Stewart, V. A., Parsons, J. C., Belasco, D. L. & Hepler, D. I. (1991). Chemoprophylactic effects of milbemycin oxime against larvae of Dirofilaria immitis during prepatent development. American Journal of Veterinary Research, 52, 2040-2042.
  • Jernigan, A. D., McTier, T. L., Chieffo, C., Thomas, C. A., Krautmann, M. J., Hair, J. A., Young, D. R., Wang, C. & Rowan, T. G. (2000). Efficacy of selamectin against experimentally induced tick (Rhipicephalus sanguineus and Dermacentor variabilis) infestations on dogs. Veterinary Parasitology, 91, 359-375.
  • Johnson-Arbor K. (2022). Ivermectin: a mini-review. Clinic Toxicology (Philadelphia), 60, 571-575. Karademir, Ü. (2005). Köpeklerde ivermektin ve doramektinin ağız ve derialtı yol ile uygulanmalarını takiben karşılaştırılmalı farmakokinetikleri. Yüksek Lisans Tezi, Adnan Menderes Üniversitesi Sağlık Bilimleri Enstitüsü, Aydın.
  • Kidwell, J. H., Buckley, G. J., Allen, A. E. & Bandt, C. (2014). Use of IV lipid emulsion for treatment of ivermectin toxicosis in a cat. Journal of the American Animal Hospital Association, 50, 59-61.
  • Kirkpatrick, C. E. & Megella, C. (1987). Use of ivermectin in treatment of Aelurostrongylus abstrusus and Toxocara cati infections in a cat. Journal of the American Veterinary Medical Association, 190, 1309-1310.
  • Krämer, F., Hammerstein, R., Stoye, M. & Epe C. (2006). Investigations into the prevention of prenatal and lactogenic Toxocara canis infections in puppies by application of moxidectin to the pregnant dog. Journal of Veterinary Medicine B Infectious Diseases and Veterinary Public Health, 53, 218-223.
  • Laing, R., Gillan, V. & Devaney, E. (2017). Ivermectin - old drug, new tricks? Trends in Parasitology, 33, 463-472. Little, S. & Otranto, D. (2019). Tradition and innovation: Selamectin plus sarolaner. A new tool to control endo- and ectoparasites of cats-Studies from North America and Japan. Veterinary Parasitology, 270 Suppl 1, S1-S2.
  • Lok, J. B., Knight, D. H., Selavka, C. M., Eynard, J., Zhang, Y. & Bergman, R. N. (1995). Studies of reproductive competence in male Dirofilaria immitis treated with milbemycin oxime. Tropical Medicine and Parasitology, 46, 235-240.
  • McCall, J. W. (2005). The safety-net story about macrocyclic lactone heartworm preventives: a review, an update, and recommendations. Veterinary Parasitology, 133, 197-206.
  • McKellar, Q. A. & Benchaoui, H. A. (1996). Avermectins and milbemycins. Journal of Veterinary Pharmacology and Therapeutics, 19, 331-351.
  • Mealey, K. L. (2004). Therapeutic implications of the MDR-1 gene. Journal of Veterinary Pharmacology and Therapeutics, 27, 257-264.
  • Mealey, K. L. & Burke, N. S. (2015). Identification of a nonsense mutation in feline ABCB1. Journal of Veterinary Pharmacology and Therapeutics, 38, 429-433.
  • Mealey, K. L. & Meurs, K. M. (2008). Breed distribution of the ABCB1-1Delta (multidrug sensitivity) polymorphism among dogs undergoing ABCB1 genotyping. Journal of the American Veterinary Medical Association, 233, 921-924.
  • Merola, V. M. & Eubig, P. A. (2012). Toxicology of avermectins and milbemycins (macrocylic lactones) and the role of P-glycoprotein in dogs and cats. Veterinary Clinics of North America: Small Animal Practice, 42, 313-333.
  • Merola, V., Khan, S. & Gwaltney-Brant, S. (2009). Ivermectin toxicosis in dogs: a retrospective study. Journal of the American Animal Hospital Association, 45, 106-111.
  • Muhammad, G., Jabbar, A., Khan, M. Z. & Saqib, M. (2004). Use of neostigmine in massive ivermectin toxicity in cats. Veterinary and Human Toxicology, 46, 28-29.
  • Mueller, R. S. (2012). An update on the therapy of canine demodicosis. Compendium: Continuing Education for Veterinarians, 34, E1-4.
  • Nelson, T., McCall, J., Jones, S. & Moorhead, A. (2020). Current Canine Guidelines for the Prevention, Diagnosis, and Management of Heartworm (Dirofilaria immitis) Infection in Dogs. American Heartworm Society Erişim Adresi: AHS_Canine_Guidelines_11_13_20.pdf d3ft8sckhnqim2.cloudfront.net. Erişim Tarihi: 02.12.2022.
  • Parton, K., Wiffen, E. M., Haglund, N. D. & Cave, N. J. (2012). Macrocyclic lactone toxicity due to abamectin in farm dogs without the ABCB1 gene mutation. New Zealand Veterinary Journal, 60, 194-197.
  • Paul, A. J., Tranquilli, W. J. & Hutchens, D. E. (2000). Safety of moxidectin in avermectin-sensitive collies. American Journal of Veterinary Research, 61, 482-483.
  • Perez, R., Cabezas, I., Sutra, J. F., Galtier, P. & Alvinerie, M. (2001). Faecal excretion profile of moxidectin and ivermectin after oral administration in horses. Veterinary Journal, 161, 85-92.
  • Plumb, D. C. (2011). Plumb’s Veterinary Drug Handbook. Seventh Ed. Wiley Blackwell.
  • Pritchard, J. (2010). Treating ivermectin toxicity in cats. Veterinary Record, 166, 766.
  • Prichard, R., Menez, C. & Lespine, A. (2012). Moxidectin and the avermectins: consanguinity but not identity. Internaitonal Journal for Parasitology: Drug and Drug Resistance, 2, 134-153.
  • Tranquilli, W. J., Paul, A. J. & Seward, R. L. (1989). Ivermectin plasma concentrations in collies sensitive to ivermectin-induced toxicosis. American Journal of Veterinary Research, 50, 769-770.
  • Tranquilli, W. J., Paul, A. J., Seward, R. L., Todd, K. S. & Dipietro, J. A. (1987). Response to physostigmine administration in collie dogs exhibiting ivermectin toxicosis. Journal of Veterinary Pharmacology and Terapeutics, 10, 96-100.
  • Vercruysse, J. (2002). Macrocyclic Lactones in Antiparasitic Therapy. Belgium: CABI Publishing.
  • Yarsan, E. & Pehlivan, S. (2020). Veteriner hekimlikte etiket dışı ilaç kullanımı: antimikrobiyal ilaçlar. Veteriner Farmakoloji ve Toksikoloji Derneği Bülteni, 11, 134-150.
  • Wiebe, V. J. & Howard, J. P. (2009). Pharmacologic advances in canine and feline reproduction. Topics in Companion Animal Medicine, 24, 71-99.

KÖPEK VE KEDİDE PARAZİT HASTALIKLARININ TEDAVİSİNDE MAKROSİKLİK LAKTONLAR

Year 2023, Volume: 14 Issue: 2, 88 - 97, 01.09.2023
https://doi.org/10.38137/vftd.1283923

Abstract

Makrosiklik laktonlar köpek ve kedide bazı parazitlerin tedavisinde ruhsatlıdır. Bu bileşikler zaman zaman parazit tedavisinde etiket dışı (off-label) da kullanılmaktadır. Bu derlemede makrosiklik laktonların köpek ve kedi parazitlerine kullanımı hakkında bilgi verilmesi amaçlanmıştır.

References

  • Arthur, R. G., Bowman, D. D., Slone, R. L. & Travis, L. E. (2005). Imidacloprid plus moxidectin topical solution for the prevention of heartworm disease (Dirofiloria immitis) in dogs. Parasitology Research, 97 (Suppl 1), S76-S80.
  • Bahçivan, E. & Oğuz, H. (2019). Zehirlenmelerde intravenöz lipit emülsiyonu tedavisi. Dicle Üniversitesi Veteriner Fakültesi Dergisi, 12, 70–77.
  • Bates, N., Chatterton, J., Robbins, C., Wells, K., Hughes, J., Stone, M. & Campbell, A. (2013). Lipid infusion in the management of poisoning: a report of 6 canine cases. Veterinary Record, 172, 339.
  • Bishop, B. F., Bruce, C. I., Evans, N. A., Goudie, A. C., Gration, K. A., Gibson, S. P., Pacey, M. S., Perry, D. A., Walshe, N. D. & Witty, M. J. (2000). Selamectin: a novel broad-spectrum endectocide for dogs and cats. Veterinary Parasitology, 91, 163-176.
  • Blagburn, B. L., Hendrix, C. M., Lindsay, D. S. & Vaughan, J. L. (1987). Anthelmintic efficacy of ivermectin in naturally parasitized cats. American Journal of Veterinary Research, 48, 670-672.
  • Blagburn, B. L., Hendrix, C. M., Lindsay, D. S., Vaughan, J. L., Hepler, D. I. & Wright, J. C. (1992). Efficacy of milbemycin oxime against naturally acquired or experimentally induced Ancylostoma spp. and Trichuris vulpis infections in dogs. American Journal of Veterinary Research, 53, 513-516.
  • Bowman, D. D., Lin, D. S., Johnson, R. C. & Hepler, D. I. (1991). Effect of milbemycin oxime on adult Ancylostoma caninum and Uncinaria stenocephala in dogs with experimentally induced infections. American Journal of Veterinary Research, 52, 64-67.
  • Bowman, D. D. (2014). Georgis’ Parasitology for Veterinarians. 10th ed. St Louis Missouri: Elsevier Saunders. Boy, M. G., Six, R. H., Thomas, C. A., Novotny, M. J., Smothers, C. D., Rowan, T. G. & Jernigan, A. D. (2000). Efficacy and safety of selamectin against fleas and heartworms in dogs and cats presented as veterinary patients in North America. Veterinary Parasitology, 91, 233-250.
  • Crandell, D. E. & Weinberg, G. L. (2009). Moxidectin toxicosis in a puppy successfully treated with intravenous lipids. Journal of Veterinary Emergency and Critical Care, 19, 181-186.
  • El-Saber Batiha, G., Alqahtani, A., Ilesanmi, O. B., Saati, A. A., El-Mleeh, A., Hetta, H. F. & Magdy Beshbishy, A. (2020). Avermectin derivatives, pharmacokinetics, therapeutic and toxic dosages, mechanism of action, and their biological effects. Pharmaceuticals (Basel), 13, 196.
  • Geyer, J. & Janko, C. (2012). Treatment of MDR1 mutant dogs with macrocyclic lactones. Current Pharmaceutical Biotechnology, 13, 969-986.
  • Grieve, R. B., Frank, G. R., Stewart, V. A., Parsons, J. C., Belasco, D. L. & Hepler, D. I. (1991). Chemoprophylactic effects of milbemycin oxime against larvae of Dirofilaria immitis during prepatent development. American Journal of Veterinary Research, 52, 2040-2042.
  • Jernigan, A. D., McTier, T. L., Chieffo, C., Thomas, C. A., Krautmann, M. J., Hair, J. A., Young, D. R., Wang, C. & Rowan, T. G. (2000). Efficacy of selamectin against experimentally induced tick (Rhipicephalus sanguineus and Dermacentor variabilis) infestations on dogs. Veterinary Parasitology, 91, 359-375.
  • Johnson-Arbor K. (2022). Ivermectin: a mini-review. Clinic Toxicology (Philadelphia), 60, 571-575. Karademir, Ü. (2005). Köpeklerde ivermektin ve doramektinin ağız ve derialtı yol ile uygulanmalarını takiben karşılaştırılmalı farmakokinetikleri. Yüksek Lisans Tezi, Adnan Menderes Üniversitesi Sağlık Bilimleri Enstitüsü, Aydın.
  • Kidwell, J. H., Buckley, G. J., Allen, A. E. & Bandt, C. (2014). Use of IV lipid emulsion for treatment of ivermectin toxicosis in a cat. Journal of the American Animal Hospital Association, 50, 59-61.
  • Kirkpatrick, C. E. & Megella, C. (1987). Use of ivermectin in treatment of Aelurostrongylus abstrusus and Toxocara cati infections in a cat. Journal of the American Veterinary Medical Association, 190, 1309-1310.
  • Krämer, F., Hammerstein, R., Stoye, M. & Epe C. (2006). Investigations into the prevention of prenatal and lactogenic Toxocara canis infections in puppies by application of moxidectin to the pregnant dog. Journal of Veterinary Medicine B Infectious Diseases and Veterinary Public Health, 53, 218-223.
  • Laing, R., Gillan, V. & Devaney, E. (2017). Ivermectin - old drug, new tricks? Trends in Parasitology, 33, 463-472. Little, S. & Otranto, D. (2019). Tradition and innovation: Selamectin plus sarolaner. A new tool to control endo- and ectoparasites of cats-Studies from North America and Japan. Veterinary Parasitology, 270 Suppl 1, S1-S2.
  • Lok, J. B., Knight, D. H., Selavka, C. M., Eynard, J., Zhang, Y. & Bergman, R. N. (1995). Studies of reproductive competence in male Dirofilaria immitis treated with milbemycin oxime. Tropical Medicine and Parasitology, 46, 235-240.
  • McCall, J. W. (2005). The safety-net story about macrocyclic lactone heartworm preventives: a review, an update, and recommendations. Veterinary Parasitology, 133, 197-206.
  • McKellar, Q. A. & Benchaoui, H. A. (1996). Avermectins and milbemycins. Journal of Veterinary Pharmacology and Therapeutics, 19, 331-351.
  • Mealey, K. L. (2004). Therapeutic implications of the MDR-1 gene. Journal of Veterinary Pharmacology and Therapeutics, 27, 257-264.
  • Mealey, K. L. & Burke, N. S. (2015). Identification of a nonsense mutation in feline ABCB1. Journal of Veterinary Pharmacology and Therapeutics, 38, 429-433.
  • Mealey, K. L. & Meurs, K. M. (2008). Breed distribution of the ABCB1-1Delta (multidrug sensitivity) polymorphism among dogs undergoing ABCB1 genotyping. Journal of the American Veterinary Medical Association, 233, 921-924.
  • Merola, V. M. & Eubig, P. A. (2012). Toxicology of avermectins and milbemycins (macrocylic lactones) and the role of P-glycoprotein in dogs and cats. Veterinary Clinics of North America: Small Animal Practice, 42, 313-333.
  • Merola, V., Khan, S. & Gwaltney-Brant, S. (2009). Ivermectin toxicosis in dogs: a retrospective study. Journal of the American Animal Hospital Association, 45, 106-111.
  • Muhammad, G., Jabbar, A., Khan, M. Z. & Saqib, M. (2004). Use of neostigmine in massive ivermectin toxicity in cats. Veterinary and Human Toxicology, 46, 28-29.
  • Mueller, R. S. (2012). An update on the therapy of canine demodicosis. Compendium: Continuing Education for Veterinarians, 34, E1-4.
  • Nelson, T., McCall, J., Jones, S. & Moorhead, A. (2020). Current Canine Guidelines for the Prevention, Diagnosis, and Management of Heartworm (Dirofilaria immitis) Infection in Dogs. American Heartworm Society Erişim Adresi: AHS_Canine_Guidelines_11_13_20.pdf d3ft8sckhnqim2.cloudfront.net. Erişim Tarihi: 02.12.2022.
  • Parton, K., Wiffen, E. M., Haglund, N. D. & Cave, N. J. (2012). Macrocyclic lactone toxicity due to abamectin in farm dogs without the ABCB1 gene mutation. New Zealand Veterinary Journal, 60, 194-197.
  • Paul, A. J., Tranquilli, W. J. & Hutchens, D. E. (2000). Safety of moxidectin in avermectin-sensitive collies. American Journal of Veterinary Research, 61, 482-483.
  • Perez, R., Cabezas, I., Sutra, J. F., Galtier, P. & Alvinerie, M. (2001). Faecal excretion profile of moxidectin and ivermectin after oral administration in horses. Veterinary Journal, 161, 85-92.
  • Plumb, D. C. (2011). Plumb’s Veterinary Drug Handbook. Seventh Ed. Wiley Blackwell.
  • Pritchard, J. (2010). Treating ivermectin toxicity in cats. Veterinary Record, 166, 766.
  • Prichard, R., Menez, C. & Lespine, A. (2012). Moxidectin and the avermectins: consanguinity but not identity. Internaitonal Journal for Parasitology: Drug and Drug Resistance, 2, 134-153.
  • Tranquilli, W. J., Paul, A. J. & Seward, R. L. (1989). Ivermectin plasma concentrations in collies sensitive to ivermectin-induced toxicosis. American Journal of Veterinary Research, 50, 769-770.
  • Tranquilli, W. J., Paul, A. J., Seward, R. L., Todd, K. S. & Dipietro, J. A. (1987). Response to physostigmine administration in collie dogs exhibiting ivermectin toxicosis. Journal of Veterinary Pharmacology and Terapeutics, 10, 96-100.
  • Vercruysse, J. (2002). Macrocyclic Lactones in Antiparasitic Therapy. Belgium: CABI Publishing.
  • Yarsan, E. & Pehlivan, S. (2020). Veteriner hekimlikte etiket dışı ilaç kullanımı: antimikrobiyal ilaçlar. Veteriner Farmakoloji ve Toksikoloji Derneği Bülteni, 11, 134-150.
  • Wiebe, V. J. & Howard, J. P. (2009). Pharmacologic advances in canine and feline reproduction. Topics in Companion Animal Medicine, 24, 71-99.
There are 40 citations in total.

Details

Primary Language Turkish
Subjects Veterinary Sciences
Journal Section Review
Authors

Beyza Avcı 0000-0002-0434-4471

Kader Yıldız 0000-0001-5802-6156

Publication Date September 1, 2023
Acceptance Date July 3, 2023
Published in Issue Year 2023 Volume: 14 Issue: 2

Cite

APA Avcı, B., & Yıldız, K. (2023). KÖPEK VE KEDİDE PARAZİT HASTALIKLARININ TEDAVİSİNDE MAKROSİKLİK LAKTONLAR. Veteriner Farmakoloji Ve Toksikoloji Derneği Bülteni, 14(2), 88-97. https://doi.org/10.38137/vftd.1283923