The effect of cefquinome on hematological and biochemical parameters following repeated subcutaneous administrations in sheep

Year 2022, Volume: 1 Issue: 1, 1 - 7, 30.06.2022

Orhan Çorum , Kamil Üney Ayşe Er Duygu Durna Corum

Abstract

The objective of this study was to evaluate the effect of cefquinome on hematological and biochemical parameters following repeated subcutaneous administrations in sheep. The study was conducted with six clinically healthy Merino sheep with age and body weight of 1.5 ± 0.2 years and 39 ± 2.7 kg, respectively. Cefquinome was administered subcutaneously to the sheep once a day for five days at a dose of 2.5 mg/kg. Blood samples were collected by jugular venipuncture prior to drug administration (0 h) and at 48 h and 120 h following the first drug administration. Blood samples were analyzed to determine hematological and biochemical parameters. Hematological and biochemical parameters did not alter following repeated subcutaneous administration of cefquinome (P > 0.05). These results indicate that cefquinome could be safe and well-tolerated following repeated subcutaneous administrations of 2.5 mg/kg once daily for five consecutive days in sheep. However, there is a need for molecular and histopathological investigation of the safety of cefquinome after repeated administration in sheep at different doses and administration routes.

Keywords

Biochemistry, cefquinome, hematology, sheep

Supporting Institution

Selcuk University

Project Number

15401151

References

• Altan, F., Erol, H., Altan, S., Arıcan, M., Elmas, M., & Uney, K. (2018). Effect of multiple- dose administration of cefquinome on hematological and biochemical parameters in horse. The Journal of Veterinary Medicine, University of Dicle, 12(1), 46–52.
• Caprile, K.A. (1988). The cephalosporin antimicrobial agents: a comprehensive review.
• Journal of Veterinary Pharmacology and Therapeutics, 11(1), 1–32.
• Corum, O., Corum, D. D., Er, A., & Uney, K. (2019). Pharmacokinetics of cefquinome after single and repeated subcutaneous administrations in sheep. Journal of Veterinary Pharmacology and Therapeutics, 42(6), 647–653. https://doi.org/10.1111/jvp.12750
• Corum, O., Dik, B., Bahcivan, E., Eser, H., Er, A., & Yazar, E. (2016). Cardiac safety of gamithromycin in ewes. Eurasian Journal of Veterinary Sciences, 32, 242–245. https://doi.org/10.15312/EurasianJVetSci.2016422395.
• Corum, O., Er, Ayse., Dik, Burak., Eser, Hatice., Bahcivan, E., & Yazar, E. (2015).
• Determination of the safety of tulathromycin in sheep. Eurasian Journal of Veterinary Sciences, 31(3), 152–157. https://doi.org/10.15312/EurasianJVetSci.2015310972.
• CVMP, (1999). Cefquinome (Extension to Pigs). Summary Report (2). EMEA/MRL/545/99- FINAL. European Agency for the Evaluation of Medicinal Products, London, UK.
• CVMP, (2003). Cefquinome (Extension to horses). Summary Report (3). EMEA/MRL/ 883/03-FINAL. European Agency for the Evaluation of Medicinal Products, London, UK.
• CVMP, (1995). Cefquinome. Summary report. EMEA/MRL/005 /95. European Agency for the Evaluation of Medicinal Products, London, UK.
• Durna-Corum, D., & Yıldız, R. (2020). Effect of multiple-dose administration of carprofen on hematological and biochemical parameters in sheep. Eurasian Journal of Veterinary Sciences, 36(3), 166–171. https://doi.org/10.15312/EurasianJVetSci.2020.274.
• Durckheimer, W., Adam, F., Fischer, G., & Kirrstetter, R. (1988). Recent developments in the field of cephem antibiotics. Advances in Drug Research, 17, 61–234, https://doi.org/10.1016/B978-0-12-013317-8.50006-X.
• Kant, L., Ranjan, A., & Ranjan, R. (2019). Hematobiochemical changes following repeated cefquinome administration in camel (Camelus dromedarius). Indian Journal of Veterinary Medicine, 39, 43–45.
• Kerr, M.G. (2002a). Veterinary Laboratory Medicine, (2nd ed.). Blackwell Science. Kerr, M.G. (2002b). Veterinary Laboratory Medicine, (2nd ed.). Blackwell Science.
• Limbert, M., Isert, D., Klesel, N., Markus, A., Seeger, K., Seibert, G., & Schrinner, E. (1991).
• Antibacterial activities in vitro and in vivo and pharmacokinetics of cefquinome (HR 111V), a new broad-spectrum cephalosporin. Antimicrobial Agents and Chemotherapy, 35(1), 14–19. https://doi.org/10.1128/AAC.35.1.14.
• Maden, M., Tras, B., Bas A.A., Elmas, M., Yazar, E., & Birdane, F.M. (2001).
• Pharmacology: Investigation of biochemical and haematological side effects of cefquinome in healthy dogs, Veterinary Quarterly, 23, 32–34. https://doi.org/10.1080/01652176.2001.9695072.
• Mangal, M., & Sharma, S.K. (2015). Effect of repeated administration of cefquinome on biochemical and hematological parameters in buffalo calves. Toxicology international, 22(1), 110-113 https://doi.org/10.4103/0971-6580.172267.
• Rana, M.P., Sadariya, K.A., & Thaker, A.M. (2015). Blood parameters on concurrent administration of cefquinome and tolfenamic acid in sheep. Indian Journal of Small Ruminants, 21(2), 359–361. https://doi.org/10.5958/0973-9718.2015.00042.2.
• Turgut, K. (2000). Veterinary Clinic Laboratory Diagnosis, Bahcivanlar Press.