The effect of pentoxifylline administration at different doses on hematological and biochemical parameters in sheep

Year 2022, Volume: 1 Issue: 2, 10 - 16, 31.12.2022

Duygu Durna Çorum , Orhan Çorum , Ayşe Er , Kamil Üney

Abstract

The aim of the present study was to determine the effect of administration of single increasing doses of pentoxifylline on biochemical and hematological parameters in sheep. The study was carried out on six healthy Merino sheep. Pentoxifylline was given to sheep intravenously at doses of 10, 20, and 40 mg/ kg. Blood samples were taken from the jugular vein before (0 hour) and after (12 hour) pentoxifylline administration. Biochemical parameters such as creatine kinase, albumin, blood urea nitrogen, creatinine, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, gamma glutamyltransferase, cholesterol, triglyceride, total bilirubin and total protein were measured in autoanalyzer. Hematological parameters such as hemoglobin, hematocrit, platelet, red blood cells and white blood cells were determined in blood cell counter. Hematological parameters did not alter between the groups, although it was found that the hematocrit value in 20 mg/ kg dosage group dropped. There were no significant changes in biochemical values following administration of the pentoxifylline at all dose level. These results show that pentoxifylline does not cause significant changes in biochemical and hematological parameters in sheep after intravenous administration at different doses. However, the safety study on pentoxifylline is also also necessary for multiple ascending doses in sheep.

Keywords

Biochemical, hematological, sheep, pentoxifylline.

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