A Case Report of Hepatosplenomegaly Due to Chronic Salmonellosis in Holstein Calves

Year 2023, Volume: 2 Issue: 2, 28 - 33, 31.12.2023

Alper Ertürk , Selçuk Üngür

https://doi.org/10.61262/vetjku.1385979

Abstract

In this case report, our aim was to present the clinical, macroscopic, bacteriological, and antibiogram results of a chronic salmonellosis case in calves on a dairy farm. A total of 12 Holstein calves weaned at 75-90 days of age on a dairy farm with clinical signs were presented in the case report. The calves displayed intermittent fever, diarrhea, and pneumonia that did not respond to treatment. The most notable finding at necropsy was hepatosplenomegaly. The diagnosis of Salmonella spp. was confirmed from the samples taken from the calves, and antibiograms revealed the resistance to many antibiotics. The disease did not recur following attention to management practices and application of protective hyperimmune serum. The presented case report emphasizes that chronic Salmonella spp. infection may lead to severe losses in calves, highlighting pathological findings, antibiotic resistance, and preventive and management practices.

Keywords

Calf, chronic salmonellosis, hepatosplenomegaly.

References

• Casaux, M. L., Neto, W. S., Schild, C. O., Costa, R. A., Macías-Rioseco, M., Caffarena, R. D., Silveira, C. S., Araoz, V., Diaz, B. D., Giannitti, F., & Fraga, M. (2023). Epidemiological and clinicopathological findings in 15 fatal outbreaks of salmonellosis in dairy calves and virulence genes in the causative Salmonella enterica Typhimurium and Dublin strains. Brazilian Journal of Microbiology, 54(1), 475-490. https://doi.org/10.1007/s42770-022-00898-9
• Costa, R. A., Casaux, M. L., Caffarena, R. D., Macias-Rioseco, M., Schild, C. O., Fraga, M., Riet-Correa, F., & Giannitti, F. (2018). Urocystitis and ureteritis in holstein calves with septicaemia caused by Salmonella enterica serotype Dublin. Journal of Comparative Pathology, 164, 32-36. https://doi.org/10.1016/j.jcpa.2018.08.005
• de Aguiar, A., Di Santis, G. W., Müller, M. C., Baptista, A. A. S., dos Santos, B. Q., Lisboa, J. A. N., & Bracarense, A. P. F. R. L. (2021). Salmonellosis in calves by serovar Dublin in Paraná State, Brazil-clinicopathological aspects. Acta Scientiae Veterinariae, 49. https://doi.org/10.22456/1679-9216.113852
• Evans, S. J., & Davies, R. H. (1996). Case control study of multiple-resistant S. thyphimurium DT1 04 infection of cattle in Great Britain. Veterinary Record, 139, 557-557.https://doi.org/10.1002/vetr.00100054
• Hadimli, H. H., Sayın, Z., & Erganiş, O. (2011). Buzağılarda Salmonella Dublin enfeksiyonu ve otojen aşı uygulaması ile kontrolü. Eurasian Journal of Veterinary Sciences, 27(2), 93-98.
• Jackson, A., Nanton, M. R., O’Donnell, H., Akue, A. D., & McSorley, S. J. (2010). Innate immune activation during Salmonella infection initiates extramedullary erythropoiesis and splenomegaly. The Journal of Immunology, 185(10), 6198-6204. http://doi.org/10.4049/jimmunol.1001198
• Jones, B. D., & Falkow, S. (1996). Salmonellosis: host immune responses and bacterial virulence determinants. Annual Review of Immunology, 14(1), 533-561. https://doi.org/10.1146/annurev.immunol.14.1.533
• Mohler, V. L., Izzo, M. M., & House, J. K. (2009). Salmonella in calves. Veterinary clinics of North America: Food animal practice, 25(1), 37-54. https://doi.org/10.1016/j.cvfa.2008.10.009
• Molossi, F. A., Cecco, B. S. D., Henker, L. C., Vargas, T. P., Lorenzett, M. P., Bianchi, M. V., Lorenzo, C. D., Sonne, L., Driemeir, D., & Pavarini, S. P. (2021). Epidemiological and pathological aspects of salmonellosis in cattle in southern Brazil. Ciência Rural, 51. https://doi.org/10.1590/0103-8478cr20200459
• Pecoraro, H. L., Thompson, B., & Duhamel, G. E. (2017). Histopathology case definition of naturally acquired Salmonella enterica serovar Dublin infection in young Holstein cattle in the northeastern United States. Journal of Veterinary Diagnostic Investigation, 29(6), 860-864. https://doi.org/10.1177/1040638717712757
• Ramachandran, S., Godfrey, J. J., & Perera, M. V. (1974). Typhoid hepatitis. Journal of the American Medical Association, 230(2), 236-240. doi:10.1001/jama.1974.03240020026016
• Rosche, K. L., Aljasham, A. T., Kipfer, J. N., Piatkowski, B. T., & Konjufca, V. (2015). Infection with Salmonella enterica serovar Typhimurium leads to increased proportions of F4/80+ red pulp macrophages and decreased proportions of B and T lymphocytes in the spleen. PloS One, 10(6), e0130092. https://doi.org/10.1371/journal.pone.0130092
• Smith, B. P. (2009). Salmonellosis in ruminants. In: Smith, B. P. (Ed.), Large Animal Internal Medicine (4th ed.).
• Varma, J. K., Marcus, R., Stenzel, S. A., Hanna, S. S., Gettner, S., Anderson, B. J., Hayes, T., Shiferaw, B., Crume, T. L., Joyce, K., Fullerton, K. E., Voetsch, A. C., & Angulo, F. J. (2006). Highly resistant Salmonella Newport- MDRAmpC transmitted through the domestic US food supply: a FoodNet casecontrol study of sporadic Salmonella Newport infections, 2002–2003. The Journal of Infectious Diseases, 194(2), 222–230. https://doi.org/10.1086/505084
• Wray, C., & Davies, R. (2000). Salmonella infections in cattle. In: Wray, C., Wray, W. (Ed.), Salmonella in domestic animals (1st ed., pp. 169-190). New York, CABI Publishing.